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POU3F3 POU class 3 homeobox 3 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_006236 Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA. Full Length $435.87
ORF Sequence $435.87


Gene Symbol POU3F3
Entrez Gene ID 5455
Full Name POU class 3 homeobox 3
Synonyms BRN1, OTF8
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q12.1
Summary POU3F3 is a member of the class III POU family of transcription factors (see POU3F1; MIM 602479) that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences (summarized by Sumiyama et al., 1996 [PubMed 8703082]).[supplied by OMIM].
Disorder

MIM: 602480
mRNA NM_006236, 5453935
Protein NP_006227, 5453936
Product POU domain, class 3, transcription factor 3
RefSeq Status PROVISIONAL
Homo sapiens (human)POU3F3NP_006227.1
Pan troglodytes (chimpanzee)POU3F3XP_525843.2
Bos taurus (cattle)POU3F3XP_001787898.1
Mus musculus (house mouse)Pou3f3NP_032926.2
Rattus norvegicus (Norway rat)Pou3f3NP_620192.1
Danio rerio (zebrafish)pou3f3aNP_571225.1
Danio rerio (zebrafish)pou3f3bNP_571177.2
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001822kidney developmentIEA
GO:0006351transcription, DNA-dependentTAS
GO:0007275multicellular organismal developmentIEA
GO:0007417central nervous system developmentTAS
GO:0008284positive regulation of cell proliferationISS
GO:0010628positive regulation of gene expressionISS
GO:0021799cerebral cortex radially oriented cell migrationIEA
GO:0021869forebrain ventricular zone progenitor cell divisionIEA
GO:0043066negative regulation of apoptosisISS
GO:0045892negative regulation of transcription, DNA-dependentISS
GO:0045893positive regulation of transcription, DNA-dependentISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0072218metanephric ascending thin limb developmentISS
GO:0072227metanephric macula densa developmentISS
GO:0072233metanephric thick ascending limb developmentISS
GO:0072236metanephric loop of Henle developmentISS
GO:0072240metanephric DCT cell differentiationISS
Component
IDNameEvidence
GO:0005634nucleusISS
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0003705sequence-specific enhancer binding RNA polymerase II transcription factor activityIEA
GO:0043565sequence-specific DNA bindingISS
GeneCards POU3F3
UniProt P20264
MIM 602480
Ensembl ENSG00000198914
HGNC 9216
HPRD 03922

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