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POU3F3 POU class 3 homeobox 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu30942 NM_006236 Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu30942C NM_006236 Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol POU3F3
Entrez Gene ID 5455
Full Name POU class 3 homeobox 3
Synonyms BRN1, OTF8
General protein information
Preferred Names
POU domain, class 3, transcription factor 3
Names
POU domain, class 3, transcription factor 3
OTF-8
brn-1
oct-8
brain-1
octamer-binding protein 8
octamer-binding transcription factor 8
brain-specific homeobox/POU domain protein 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q12.1

Summary POU3F3 is a member of the class III POU family of transcription factors (see POU3F1; MIM 602479) that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences (summarized by Sumiyama et al., 1996 [PubMed 8703082]).[supplied by OMIM, Jul 2010].
Disorder

MIM: 602480

mRNA Protein Product Sequence Price Select
NM_006236, 5453935 NP_006227, 5453936 POU domain, class 3, transcription factor 3 ORF Sequence $550.00
Homo sapiens (human)POU3F3NP_006227.1
Mus musculus (house mouse)Pou3f3NP_032926.2
Rattus norvegicus (Norway rat)Pou3f3NP_620192.1
Danio rerio (zebrafish)pou3f3bNP_571177.2
Danio rerio (zebrafish)pou3f3aNP_571225.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100497507XP_004911849.1
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0007417central nervous system developmentTAS
GO:0008284positive regulation of cell proliferationISS
GO:0010628positive regulation of gene expressionISS
GO:0021799cerebral cortex radially oriented cell migrationIEA
GO:0021869forebrain ventricular zone progenitor cell divisionIEA
GO:0043066negative regulation of apoptotic processISS
GO:0045892negative regulation of transcription, DNA-templatedISS
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0072218metanephric ascending thin limb developmentISS
GO:0072227metanephric macula densa developmentISS
GO:0072233metanephric thick ascending limb developmentISS
GO:0072236metanephric loop of Henle developmentISS
GO:0072240metanephric DCT cell differentiationISS
Component
IDNameEvidence
GO:0005634nucleusISS
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingISS
GO:0071837HMG box domain bindingIEA
GeneCards POU3F3
UniProt P20264
MIM 602480
HGNC 9216
HPRD 03922

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