POU3F4 POU class 3 homeobox 4 [Homo sapiens (human)]
| Gene Symbol | POU3F4 |
| Entrez Gene ID | 5456 |
| Full Name | POU class 3 homeobox 4 |
| Synonyms | BRAIN-4, BRN4, DFN3, DFNX2, OTF9 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
X Xq21.1 |
| Summary | This gene encodes a member of the POU-III class of neural transcription factors. This gene may play a role in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations have been associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq]. |
| Disorder | MIM: 300039 Deafness, X-linked 2, 304400 (3) |
| mRNA | NM_000307, 194440735 |
| Protein | NP_000298, 110624763 |
| Product | POU domain, class 3, transcription factor 4 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | POU3F4 | NP_000298.2 |
| Canis lupus familiaris (dog) | POU3F4 | XP_549108.1 |
| Bos taurus (cattle) | POU3F4 | XP_589021.2 |
| Mus musculus (house mouse) | Pou3f4 | NP_032927.1 |
| Rattus norvegicus (Norway rat) | Pou3f4 | NP_058948.1 |
| ID | Name | Evidence |
| GO:0006351 | transcription, DNA-dependent | TAS |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA |
| GO:0007605 | sensory perception of sound | IEA |
| GO:0021879 | forebrain neuron differentiation | IEA |
| GO:0048839 | inner ear development | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0044424 | intracellular part | IEA |
Function
| ID | Name | Evidence |
| GO:0003680 | AT DNA binding | IEA |
| GO:0003690 | double-stranded DNA binding | IEA |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
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