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POU3F4 POU class 3 homeobox 4 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000307 Homo sapiens POU class 3 homeobox 4 (POU3F4), mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol POU3F4
Entrez Gene ID 5456
Full Name POU class 3 homeobox 4
Synonyms BRAIN-4, BRN-4, BRN4, DFN3, DFNX2, OCT-9, OTF-9, OTF9
General protein information
Preferred Names
POU domain, class 3, transcription factor 4
POU domain, class 3, transcription factor 4
octamer-binding transcription factor 9
brain-specific homeobox/POU domain protein 4
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012].

MIM: 300039

Deafness, X-linked 2, 304400 (3)

mRNA Protein Product Sequence Price Select
NM_000307, 433288479 NP_000298, 433288480 POU domain, class 3, transcription factor 4 ORF Sequence $400.00
Homo sapiens (human)POU3F4NP_000298.3
Pan troglodytes (chimpanzee)POU3F4XP_003317585.1
Macaca mulatta (Rhesus monkey)POU3F4XP_001104059.1
Canis lupus familiaris (dog)POU3F4XP_549108.1
Bos taurus (cattle)POU3F4XP_002699986.1
Mus musculus (house mouse)Pou3f4NP_032927.1
Rattus norvegicus (Norway rat)Pou3f4NP_058948.1
Xenopus (Silurana) tropicalis (western clawed frog)pou3f4NP_001090728.1
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0007605sensory perception of soundIEA
GO:0021879forebrain neuron differentiationIEA
GO:0090103cochlea morphogenesisISS
GO:2001054negative regulation of mesenchymal cell apoptotic processISS
GO:0003680AT DNA bindingIEA
GO:0003690double-stranded DNA bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GeneCards POU3F4
UniProt P49335
Vega OTTHUMG00000021919
MIM 300039
Ensembl ENSG00000196767
HGNC 9217
HPRD 02076

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the POU3F4 gene?

The POU3F4 gene provides instructions for making a protein that helps regulate the activity of other genes. Based on this role, the protein is called a transcription factor. The POU3F4 gene is part of a larger family of genes called POU domain genes, all of which produce transcription factors. POU domain genes play a role in determining cell types in the central nervous system during early development. Each protein in the POU domain family has two regions, called the POU-specific domain and POU homeodomain, that bind to the DNA of other genes.

The POU3F4 gene is likely to be involved in the development of the middle and inner ear, and is also active in certain regions of the brain before birth. Researchers have not determined which genes are regulated by the POU3F4 protein.


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