Sequence in raw or FASTA format:
POU3F4 POU class 3 homeobox 4 [Homo sapiens (human)]
|Entrez Gene ID||5456|
|Full Name||POU class 3 homeobox 4|
|Synonyms||BRAIN-4, BRN-4, BRN4, DFN3, DFNX2, OCT-9, OTF-9, OTF9|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012].|
Deafness, X-linked 2, 304400 (3)
|Homo sapiens (human)||POU3F4||NP_000298.3|
|Pan troglodytes (chimpanzee)||POU3F4||XP_003317585.1|
|Macaca mulatta (Rhesus monkey)||POU3F4||XP_001104059.1|
|Canis lupus familiaris (dog)||POU3F4||XP_549108.1|
|Bos taurus (cattle)||POU3F4||XP_002699986.1|
|Mus musculus (house mouse)||Pou3f4||NP_032927.1|
|Rattus norvegicus (Norway rat)||Pou3f4||NP_058948.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||pou3f4||NP_001090728.1|
|GO:0006355||regulation of transcription, DNA-templated||IEA|
|GO:0006366||transcription from RNA polymerase II promoter||IEA|
|GO:0007605||sensory perception of sound||IEA|
|GO:0021879||forebrain neuron differentiation||IEA|
|GO:2001054||negative regulation of mesenchymal cell apoptotic process||ISS|
|GO:0003680||AT DNA binding||IEA|
|GO:0003690||double-stranded DNA binding||IEA|
|GO:0003700||sequence-specific DNA binding transcription factor activity||IEA|
What is the normal function of the POU3F4 gene?
The POU3F4 gene provides instructions for making a protein that helps regulate the activity of other genes. Based on this role, the protein is called a transcription factor. The POU3F4 gene is part of a larger family of genes called POU domain genes, all of which produce transcription factors. POU domain genes play a role in determining cell types in the central nervous system during early development. Each protein in the POU domain family has two regions, called the POU-specific domain and POU homeodomain, that bind to the DNA of other genes.
The POU3F4 gene is likely to be involved in the development of the middle and inner ear, and is also active in certain regions of the brain before birth. Researchers have not determined which genes are regulated by the POU3F4 protein.
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