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UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_019077 Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol UGT1A7
Entrez Gene ID 54577
Full Name UDP glucuronosyltransferase 1 family, polypeptide A7
Synonyms UDPGT, UDPGT 1-7, UGT1G
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q37

Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606432

mRNA Protein Product Sequence Price Select
NM_019077, 41282212 NP_061950, 41282213 UDP-glucuronosyltransferase 1-7 precursor ORF Sequence $550.00
KEGG
hsa00500Starch and sucrose metabolism
hsa_M00129Ascorbate biosynthesis, animals, glucose-1P => ascorbate
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00830Retinol metabolism
hsa00053Ascorbate and aldarate metabolism
hsa00982Drug metabolism - cytochrome P450
hsa00040Pentose and glucuronate interconversions
hsa00983Drug metabolism - other enzymes
hsa00140Steroid hormone biosynthesis
hsa05204Chemical carcinogenesis
hsa00860Porphyrin and chlorophyll metabolism
WikiPathways
WP698Glucuronidation
WP702metapathway biotransformation
Reactome
REACT_6959Phase II conjugation
REACT_116145PPARA Activates Gene Expression
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22297Heme degradation
REACT_13433Biological oxidations
REACT_9431Metabolism of porphyrins
REACT_111217Metabolism
REACT_6784Glucuronidation
REACT_22258Metabolism of lipids and lipoproteins
REACT_19241Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Homo sapiens (human)UGT1A10NP_061948.1
Homo sapiens (human)UGT1A8NP_061949.3
Homo sapiens (human)UGT1A9NP_066307.1
Homo sapiens (human)UGT1A7NP_061950.2
Mus musculus (house mouse)Ugt1a10NP_964003.2
Mus musculus (house mouse)Ugt1a9NP_964006.2
Rattus norvegicus (Norway rat)Ugt1a8NP_787040.2
GeneCards UGT1A7
UniProt Q5DSZ7, Q9HAW7
MIM 606432
Ensembl ENSG00000244122
HGNC 12539
HPRD 09397

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
UDP-glucuronosyltransferase 1-7
Names
UDP-glucuronosyltransferase 1-7
UDP-glucuronosyltransferase 1-G
UDP-glucuronosyltransferase 1A7
UDP glycosyltransferase 1 family, polypeptide A7
UDP-glucuronosyltransferase 1 family polypeptide A7s
NP_061950.2

Interactant



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