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UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24768 NM_019077 Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu24768C NM_019077 Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol UGT1A7
Entrez Gene ID 54577
Full Name UDP glucuronosyltransferase 1 family, polypeptide A7
Synonyms UDPGT, UDPGT 1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G
General protein information
Preferred Names
UDP-glucuronosyltransferase 1-7
Names
UDP-glucuronosyltransferase 1-7
UDP-glucuronosyltransferase 1-G
UDP-glucuronosyltransferase 1A7
UDP glycosyltransferase 1 family, polypeptide A7
UDP-glucuronosyltransferase 1 family polypeptide A7s
NP_061950.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q37

Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606432

mRNA Protein Product Sequence Price Select
NM_019077, 41282212 NP_061950, 41282213 UDP-glucuronosyltransferase 1-7 precursor ORF Sequence $550.00
KEGG
hsa00040Pentose and glucuronate interconversions
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00053Ascorbate and aldarate metabolism
hsa00500Starch and sucrose metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa00830Retinol metabolism
hsa05204Chemical carcinogenesis
WikiPathways
WP702metapathway biotransformation
WP698Glucuronidation
Reactome
REACT_13433Biological oxidations
REACT_6784Glucuronidation
REACT_6959Phase II conjugation
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_9431Metabolism of porphyrins
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_22297Heme degradation
REACT_111217Metabolism
REACT_116145PPARA activates gene expression
Homo sapiens (human)UGT1A10NP_061948.1
Homo sapiens (human)UGT1A8NP_061949.3
Homo sapiens (human)UGT1A7NP_061950.2
Homo sapiens (human)UGT1A9NP_066307.1
Mus musculus (house mouse)Ugt1a9NP_964006.2
Mus musculus (house mouse)Ugt1a10NP_964003.2
Rattus norvegicus (Norway rat)Ugt1a8NP_787040.2
Process
IDNameEvidence
GO:0007588excretionIC
GO:0009804coumarin metabolic processIC
GO:0017144drug metabolic processIC
GO:0017144drug metabolic processIDA
GO:0042573retinoic acid metabolic processIC
GO:0043086negative regulation of catalytic activityIDA
GO:0045922negative regulation of fatty acid metabolic processIDA
GO:0051552flavone metabolic processIC
GO:0052695cellular glucuronidationIDA
GO:0052696flavonoid glucuronidationIDA
GO:0052697xenobiotic glucuronidationIDA
GO:2001030negative regulation of cellular glucuronidationIDA
Component
IDNameEvidence
GO:0005783endoplasmic reticulumIDA
GO:0005789endoplasmic reticulum membraneNAS
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0001972retinoic acid bindingIDA
GO:0004857enzyme inhibitor activityIDA
GO:0005080protein kinase C bindingIDA
GO:0008144drug bindingIDA
GO:0015020glucuronosyltransferase activityIDA
GO:0019899enzyme bindingIDA
GO:0042803protein homodimerization activityIDA
GO:0042803protein homodimerization activityIPI
GO:0046982protein heterodimerization activityIDA
GO:0046982protein heterodimerization activityIPI
GeneCards UGT1A7
UniProt Q5DSZ7, Q9HAW7
Vega OTTHUMG00000059004
MIM 606432
Ensembl ENSG00000244122
HGNC 12539
HPRD 09397

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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