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UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_019077 Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7), mRNA. Full Length $676.57
ORF Sequence $461.97


Gene Symbol UGT1A7
Entrez Gene ID 54577
Full Name UDP glucuronosyltransferase 1 family, polypeptide A7
Synonyms UDPGT, UDPGT 1-7, UGT1G
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q37
Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq].
Disorder

MIM: 606432
mRNA NM_019077, 41282212
Protein NP_061950, 41282213
Product UDP-glucuronosyltransferase 1-7 precursor
RefSeq Status REVIEWED
KEGG
hsa00983Drug metabolism - other enzymes
hsa00140Steroid hormone biosynthesis
hsa00860Porphyrin and chlorophyll metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00053Ascorbate and aldarate metabolism
hsa00830Retinol metabolism
hsa00500Starch and sucrose metabolism
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00040Pentose and glucuronate interconversions
WikiPathways
WP698Glucuronidation
WP702metapathway biotransformation
Reactome
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_13433Biological oxidations
REACT_9431Metabolism of porphyrins
REACT_22297Heme degradation
REACT_6784Glucuronidation
REACT_22258Metabolism of lipids and lipoproteins
REACT_19241Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_6959Phase II conjugation
Homo sapiens (human)UGT1A10NP_061948.1
Homo sapiens (human)UGT1A8NP_061949.3
Homo sapiens (human)UGT1A9NP_066307.1
Homo sapiens (human)UGT1A7NP_061950.2
Mus musculus (house mouse)Ugt1a10NP_964003.1
Mus musculus (house mouse)Ugt1a9NP_964006.1
Rattus norvegicus (Norway rat)Ugt1a9NP_958828.1
Process
IDNameEvidence
GO:0006805xenobiotic metabolic processIDA
GO:0007588excretionIC
GO:0008152metabolic processIEA
GO:0009804coumarin metabolic processIC
GO:0009812flavonoid metabolic processIDA
GO:0017144drug metabolic processIC
GO:0017144drug metabolic processIDA
GO:0042573retinoic acid metabolic processIC
GO:0043086negative regulation of catalytic activityIDA
GO:0045922negative regulation of fatty acid metabolic processIDA
GO:0051552flavone metabolic processIC
Component
IDNameEvidence
GO:0005783endoplasmic reticulumIDA
GO:0005789endoplasmic reticulum membraneNAS
GO:0005792microsomeIDA
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
Function
IDNameEvidence
GO:0001972retinoic acid bindingIDA
GO:0004857enzyme inhibitor activityIDA
GO:0005080protein kinase C bindingIPI
GO:0008144drug bindingIDA
GO:0015020glucuronosyltransferase activityIDA
GO:0019899enzyme bindingIDA
GO:0042803protein homodimerization activityIPI
GO:0046982protein heterodimerization activityIPI
GeneCards UGT1A7
UniProt Q5DSZ7, Q9HAW7
MIM 606432
Ensembl ENSG00000244122
HGNC 12539
HPRD 09397

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