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POU4F2 POU class 4 homeobox 2 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	POU4F2
Entrez Gene ID	5458
Full Name	POU class 4 homeobox 2
Synonyms	BRN3.2, BRN3B, Brn-3b
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:4 Map Location:4q31.2
Summary	POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM].
Disorder	MIM: 113725

mRNA	NM_004575, 110347454
Protein	NP_004566, 110347455
Product	POU domain, class 4, transcription factor 2
RefSeq Status	VALIDATED

Pathway Interaction Database

p53downstreampathway

Direct p53 effectors

Homo sapiens (human)	POU4F2	NP_004566.2
Pan troglodytes (chimpanzee)	POU4F2	XP_526699.2
Canis lupus familiaris (dog)	POU4F2	XP_853453.1
Bos taurus (cattle)	POU4F2	XP_869268.2
Mus musculus (house mouse)	Pou4f2	NP_620394.2
Rattus norvegicus (Norway rat)	Pou4f2	XP_344757.1
Danio rerio (zebrafish)	pou4f2	NP_997972.1

Process

ID	Name	Evidence
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA
GO:0006351	transcription, DNA-dependent	TAS
GO:0006355	regulation of transcription, DNA-dependent	IEA
GO:0007399	nervous system development	IEA
GO:0007605	sensory perception of sound	IEA
GO:0030182	neuron differentiation	IEA
GO:0031290	retinal ganglion cell axon guidance	IEA
GO:0045597	positive regulation of cell differentiation	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0048676	axon extension involved in development	IEA
GO:0050885	neuromuscular process controlling balance	IEA
GO:0060041	retina development in camera-type eye	IEA

Component

ID	Name	Evidence
GO:0005634	nucleus	IEA
GO:0016607	nuclear speck	IEA

Function

ID	Name	Evidence
GO:0003682	chromatin binding	IEA
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA
GO:0043565	sequence-specific DNA binding	IEA

GeneCards	POU4F2
UniProt	Q12837
MIM	113725
Ensembl	ENSG00000151615
HGNC	9219
HPRD	00220

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