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POU4F2 POU class 4 homeobox 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu04465 NM_004575 Homo sapiens POU class 4 homeobox 2 (POU4F2), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu04465C NM_004575 Homo sapiens POU class 4 homeobox 2 (POU4F2), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol POU4F2
Entrez Gene ID 5458
Full Name POU class 4 homeobox 2
Synonyms BRN3.2, BRN3B, Brn-3b
General protein information
Preferred Names
POU domain, class 4, transcription factor 2
Names
POU domain, class 4, transcription factor 2
brain-3B
POU domain protein
Brn3b POU domain transcription factor
POU domain class 4 transcription factor 2
brain-specific homeobox/POU domain protein 3B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q31.2

Summary The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011].
Disorder

MIM: 113725

mRNA Protein Product Sequence Price Select
NM_004575, 110347454 NP_004566, 110347455 POU domain, class 4, transcription factor 2 ORF Sequence $400.00
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
Homo sapiens (human)POU4F2NP_004566.2
Pan troglodytes (chimpanzee)POU4F2XP_526699.2
Macaca mulatta (Rhesus monkey)POU4F2XP_001098227.1
Canis lupus familiaris (dog)POU4F2XP_853453.1
Bos taurus (cattle)POU4F2NP_001179881.1
Mus musculus (house mouse)Pou4f2NP_620394.2
Rattus norvegicus (Norway rat)Pou4f2NP_599182.1
Danio rerio (zebrafish)pou4f2NP_997972.1
Xenopus (Silurana) tropicalis (western clawed frog)pou4f2XP_004911191.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0000165MAPK cascadeIDA
GO:0006351transcription, DNA-templatedIEA
GO:0007411axon guidanceISS
GO:0007605sensory perception of soundIEA
GO:0030182neuron differentiationISS
GO:0030520intracellular estrogen receptor signaling pathwayIDA
GO:0031290retinal ganglion cell axon guidanceIEA
GO:0045597positive regulation of cell differentiationISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048675axon extensionIEA
GO:0050885neuromuscular process controlling balanceIEA
GO:0060041retina development in camera-type eyeISS
Component
IDNameEvidence
GO:0005634nucleusIC
GO:0005634nucleusISS
GO:0016607nuclear speckIEA
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionISS
GO:0003682chromatin bindingIEA
GeneCards POU4F2
UniProt Q12837
Vega OTTHUMG00000162045
MIM 113725
Ensembl ENSG00000151615
HGNC 9219
HPRD 00220

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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