Sequence in raw or FASTA format:
POU4F2 POU class 4 homeobox 2 [
Homo sapiens (human)]
Gene Symbol POU4F2
Entrez Gene ID
Full Name POU class 4 homeobox 2
Synonyms BRN3.2, BRN3B, Brn-3b
General protein information
POU domain, class 4, transcription factor 2
POU domain, class 4, transcription factor 2
POU domain protein
Brn3b POU domain transcription factor
POU domain class 4 transcription factor 2
brain-specific homeobox/POU domain protein 3B
Gene Type protein-coding
Homo sapiens (human)
Chromosome:4 Map Location:4q31.2
Summary The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011].
Pathway Interaction Database
ID Name Evidence
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS
GO:0000165 MAPK cascade IDA
GO:0006351 transcription, DNA-templated IEA
GO:0007411 axon guidance ISS
GO:0007605 sensory perception of sound IEA
GO:0030182 neuron differentiation ISS
GO:0030520 intracellular estrogen receptor signaling pathway IDA
GO:0031290 retinal ganglion cell axon guidance IEA
GO:0045597 positive regulation of cell differentiation ISS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048675 axon extension IEA
GO:0050885 neuromuscular process controlling balance IEA
GO:0060041 retina development in camera-type eye ISS
ID Name Evidence
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS
GO:0003682 chromatin binding IEA
Related articles in PubMed Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation. Reinert T, et al. PLoS One, 2012. PMID 23056278. Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment. Fujita R, et al. Cell Stress Chaperones, 2011 Jul. PMID 21279488. A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. Qiu F, et al. J Neurosci, 2008 Mar 26. PMID 18367606. Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. Budhram-Mahadeo VS, et al. Oncogene, 2008 Jan 3. PMID 17637757. Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. Calissano M, et al. FEBS Lett, 2007 May 29. PMID 17490655. See all (21) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Methylation levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 in urine specimens are promising diagnostic biomarkers for bladder cancer recurrence surveillance
Title: Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation.
Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism.
Title: A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors.
May act to alter growth properties of breast cancer and neuroblastoma cells by enhancing cyclin D1 expression in these tumor cells.
Title: Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells.
Two different microRNAs that potentially regulate the stability of Brn-3b have been identified in neuroblastoma cells.
Title: Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells.
first time that a Brn-3b POU family transcription factor has been shown to regulate a member of the catenin family, which provides insight into the molecular mechanisms by which Brn-3b expression may favour breast cancer progression and tumor invasion
Title: The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells.
Brn-3b transcription factor contributes to proliferation of neuroblastoma cells in vivo and in vitro but may also influence progression and/or invasion during tumorigenesis.
Title: The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.
Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells.
Title: Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
Levels of CDK4 mRNA and protein correlate with levels of Brn-3b in breast cancer cell lines manipulated to express different levels of Brn-3b and in human breast cancer biopsies; Brn-3b can activate the CDK4 promoter
Title: Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor.
Brn-3b expression has been shown to be a prerequisite for developmental survival of most retinal ganglion cells.
Title: Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells.
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