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POU5F1 POU class 5 homeobox 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001173531 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 3, mRNA. ORF Sequence $166.17
Peptide Services
Antibody Services
Protein Services
NM_002701 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1, mRNA. ORF Sequence $314.07
Peptide Services
Antibody Services
Protein Services
NM_203289 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 2, mRNA. ORF Sequence $166.17
Peptide Services
Antibody Services
Protein Services


Gene Symbol POU5F1
Entrez Gene ID 5460
Full Name POU class 5 homeobox 1
Synonyms MGC22487, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.31

Summary This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Mar 2010].
Disorder

MIM: 164177

mRNA Protein Product Sequence Price Select
NM_001173531, 291167756 NP_001167002, 291167757 POU domain, class 5, transcription factor 1 isoform 2 Full Length $364.53
ORF Sequence $166.17
NM_002701, 116235483 NP_002692, 42560248 POU domain, class 5, transcription factor 1 isoform 1 Full Length $409.19
ORF Sequence $314.07
NM_203289, 291167754 NP_976034, 291167755 POU domain, class 5, transcription factor 1 isoform 2 Full Length $505.47
ORF Sequence $166.17
WikiPathways
WP399Wnt Signaling Pathway and Pluripotency
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
hif2pathwayHIF-2-alpha transcription factor network
Homo sapiens (human)POU5F1NP_002692.2
Macaca mulatta (Rhesus monkey)POU5F1NP_001108427.1
Canis lupus familiaris (dog)POU5F1XP_538830.1
Bos taurus (cattle)POU5F1NP_777005.1
Mus musculus (house mouse)Pou5f1NP_038661.2
Rattus norvegicus (Norway rat)Pou5f1NP_001009178.1
GeneCards POU5F1
UniProt D2IYK3, Q01860
MIM 164177
Ensembl ENSG00000256919
HGNC 9221
HPRD 01252

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
POU domain, class 5, transcription factor 1
Names
POU domain, class 5, transcription factor 1
octamer-binding protein 3
octamer-binding protein 4
POU domain transcription factor OCT4
octamer-binding transcription factor 3
octamer-binding transcription factor-3
POU-type homeodomain-containing DNA-binding protein

Interactant

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