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POU5F1 POU class 5 homeobox 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20361 NM_002701 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu20662 NM_001173531 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu21050 NM_001285987 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu21117 NM_001285986 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu20662 NM_203289 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu20361C NM_002701 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu20662C NM_001173531 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu21050C NM_001285987 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 5, mRNA. Customized vector On-demand 7-9 $209.00
OHu21117C NM_001285986 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 4, mRNA. Customized vector On-demand 7-9 $209.00
OHu20662C NM_203289 Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol POU5F1
Entrez Gene ID 5460
Full Name POU class 5 homeobox 1
Synonyms OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4
General protein information
Preferred Names
POU domain, class 5, transcription factor 1
Names
POU domain, class 5, transcription factor 1
octamer-binding protein 3
octamer-binding protein 4
POU domain transcription factor OCT4
octamer-binding transcription factor 3
octamer-binding transcription factor-3
POU-type homeodomain-containing DNA-binding protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.31

Summary This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013].
Disorder

MIM: 164177

mRNA Protein Product Sequence Price Select
NM_001173531, 553727228 NP_001167002, 291167757 POU domain, class 5, transcription factor 1 isoform 2 ORF Sequence $159.00
NM_001285986, 553727229 NP_001272915, 553727230 POU domain, class 5, transcription factor 1 isoform 4 ORF Sequence $250.00
NM_001285987, 553727232 NP_001272916, 553727233 POU domain, class 5, transcription factor 1 isoform 3 ORF Sequence $300.00
NM_002701, 553727227 NP_002692, 42560248 POU domain, class 5, transcription factor 1 isoform 1 ORF Sequence $269.00
NM_203289, 553727231 NP_976034, 291167755 POU domain, class 5, transcription factor 1 isoform 2 ORF Sequence $159.00
WikiPathways
WP399Wnt Signaling Pathway and Pluripotency
WP706SIDS Susceptibility Pathways
WP2406Cardiac Progenitor Differentiation
Pathway Interaction Database
hif2pathwayHIF-2-alpha transcription factor network
Reactome
REACT_111045Developmental Biology
REACT_200812Transcriptional regulation of pluripotent stem cells
REACT_200670POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
REACT_200759POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Homo sapiens (human)POU5F1NP_002692.2
Pan troglodytes (chimpanzee)POU5F1NP_001238970.1
Macaca mulatta (Rhesus monkey)POU5F1NP_001108427.1
Canis lupus familiaris (dog)POU5F1XP_538830.1
Bos taurus (cattle)POU5F1NP_777005.1
Mus musculus (house mouse)Pou5f1NP_038661.2
Rattus norvegicus (Norway rat)Pou5f1NP_001009178.1
Process
IDNameEvidence
GO:0001714endodermal cell fate specificationIDA
GO:0001824blastocyst developmentISS
GO:0003130BMP signaling pathway involved in heart inductionIMP
GO:0006355regulation of transcription, DNA-templatedIDA
GO:0006366transcription from RNA polymerase II promoterISS
GO:0009611response to woundingIEP
GO:0009653anatomical structure morphogenesisTAS
GO:0009786regulation of asymmetric cell divisionISS
GO:0010468regulation of gene expressionIMP
GO:0035019somatic stem cell maintenanceIDA
GO:0035019somatic stem cell maintenanceIMP
GO:0035413positive regulation of catenin import into nucleusIDA
GO:0042789mRNA transcription from RNA polymerase II promoterISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0060391positive regulation of SMAD protein import into nucleusIDA
GO:0060795cell fate commitment involved in formation of primary germ layerIMP
GO:0060913cardiac cell fate determinationIDA
GO:0060965negative regulation of gene silencing by miRNAIMP
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathwayIMP
GO:0090308regulation of methylation-dependent chromatin silencingIDA
Component
IDNameEvidence
GO:0005634nucleusIC
GO:0005634nucleusIDA
GO:0005654nucleoplasmIDA
GO:0005667transcription factor complexIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolIDA
Function
IDNameEvidence
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityISS
GO:0003677DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0031625ubiquitin protein ligase bindingIPI
GO:0035198miRNA bindingIDA
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingIDA
GO:0044822poly(A) RNA bindingIDA
GeneCards POU5F1
UniProt D2IYK3, Q01860, F2Z381, M1S623
Vega OTTHUMG00000031206
MIM 164177
Ensembl ENSG00000204531
HGNC 9221
HPRD 01252

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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