POU5F1B POU class 5 homeobox 1B [Homo sapiens (human)]
| Gene Symbol | POU5F1B |
| Entrez Gene ID | 5462 |
| Full Name | POU class 5 homeobox 1B |
| Synonyms | OCT4-PG1, OTF3C, OTF3P1, POU5F1P1, POU5F1P4, POU5FLC20, POU5FLC8 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
8 8q24.21 |
| Summary | This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq]. |
| Disorder | MIM: |
| mRNA | NM_001159542, 227430409 |
| Protein | NP_001153014, 227430410 |
| Product | putative POU domain, class 5, transcription factor 1B |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | POU5F1B | NP_001153014.1 |
| Pan troglodytes (chimpanzee) | LOC472858 | XP_528230.1 |
| ID | Name | Evidence |
| GO:0006351 | transcription, DNA-dependent | TAS |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | TAS |
Function
| ID | Name | Evidence |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | TAS |
| GO:0043565 | sequence-specific DNA binding | IEA |
| GeneCards | POU5F1B |
| UniProt | D5K9T1, Q06416 |
| Ensembl | ENSG00000212993 |
| HGNC | 9223 |
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