PARP14 poly (ADP-ribose) polymerase family, member 14 [Homo sapiens (human)]
| Gene Symbol | PARP14 |
| Entrez Gene ID | 54625 |
| Full Name | poly (ADP-ribose) polymerase family, member 14 |
| Synonyms | BAL2, KIAA1268, PARP-14, pART8 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
3 3q21.1 |
| Summary | Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).[supplied by OMIM]. |
| Disorder | MIM: 610028 |
| mRNA | NM_017554, 154813198 |
| Protein | NP_060024, 154813199 |
| Product | poly [ADP-ribose] polymerase 14 |
| RefSeq Status | VALIDATED |
| il4_2pathway | IL4-mediated signaling events |
| Homo sapiens (human) | PARP14 | NP_060024.2 |
| Pan troglodytes (chimpanzee) | PARP14 | XP_516695.2 |
| Canis lupus familiaris (dog) | PARP14 | XP_850880.1 |
| Bos taurus (cattle) | PARP14 | XP_001251105.1 |
| Mus musculus (house mouse) | Parp14 | NP_001034619.1 |
| Rattus norvegicus (Norway rat) | Parp14 | XP_221401.4 |
| Gallus gallus (chicken) | PARP14 | XP_422113.2 |
| Danio rerio (zebrafish) | si:ch211-219a4.3 | NP_001107919.2 |
| ID | Name | Evidence |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005886 | plasma membrane | IDA |
Function
| ID | Name | Evidence |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | IEA |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA |
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