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PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17459 NM_001161779 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17481 NM_001161781 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17459 NM_001161780 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17481 NM_018444 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu42506 XM_005250986 PREDICTED: Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu42507 XM_006716592 PREDICTED: Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17459C NM_001161779 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu17481C NM_001161781 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu17459C NM_001161780 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu17481C NM_018444 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant 5, mRNA. Customized vector On-demand 7-9 $269.00
OHu42506C XM_005250986 PREDICTED: Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu42507C XM_006716592 PREDICTED: Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol PDP1
Entrez Gene ID 54704
Full Name pyruvate dehyrogenase phosphatase catalytic subunit 1
Synonyms PDH, PDP, PDPC, PPM2C
General protein information
Preferred Names
pyruvate dehyrogenase phosphatase catalytic subunit 1
Names
pyruvate dehyrogenase phosphatase catalytic subunit 1
PDP 1
PDPC 1
pyruvate dehydrogenase phosphatase catalytic subunit 1
pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
protein phosphatase 2C, magnesium-dependent, catalytic subunit
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
NP_001155251.1
NP_001155252.1
NP_001155253.1
NP_060914.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q22.1

Summary Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].
Disorder

MIM: 605993

Pyruvate dehydrogenase phosphatase deficiency, 608782 (3)

mRNA Protein Product Sequence Price Select
NM_001161779, 239985421 NP_001155251, 239985422 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 2 ORF Sequence $550.00
NM_001161780, 239985425 NP_001155252, 239985426 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 2 ORF Sequence $550.00
NM_001161781, 239985427 NP_001155253, 239985428 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 3 ORF Sequence $550.00
NM_018444, 239985429 NP_060914, 45439339 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 3 ORF Sequence $550.00
XM_005250986, 530389162 XP_005251043, 530389163 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform X1 ORF Sequence $700.00
XM_006716592, 578816055 XP_006716655, 578816056 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform X2 ORF Sequence $550.00
Reactome
REACT_12528Regulation of pyruvate dehydrogenase (PDH) complex
REACT_2071Pyruvate metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_111217Metabolism
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
Homo sapiens (human)PDP1NP_001155251.1
Pan troglodytes (chimpanzee)PDP1XP_003311894.1
Macaca mulatta (Rhesus monkey)PDP1XP_002805489.1
Canis lupus familiaris (dog)PDP1XP_005638184.1
Bos taurus (cattle)PDP1NP_001193282.1
Mus musculus (house mouse)Pdp1NP_001091700.1
Rattus norvegicus (Norway rat)Pdp1NP_001258037.1
Gallus gallus (chicken)PDP1NP_001186839.1
Danio rerio (zebrafish)pdp1NP_001104628.1
Drosophila melanogaster (fruit fly)PdpNP_572404.1
Caenorhabditis eleganspdp-1NP_491357.1
Xenopus (Silurana) tropicalis (western clawed frog)pdp1NP_001072271.1
Process
IDNameEvidence
GO:0006090pyruvate metabolic processTAS
GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvateTAS
GO:0035970peptidyl-threonine dephosphorylationIDA
GO:0044237cellular metabolic processTAS
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005759mitochondrial matrixTAS
Function
IDNameEvidence
GO:0004722protein serine/threonine phosphatase activityIDA
GO:0004741[pyruvate dehydrogenase (lipoamide)] phosphatase activityIEA
GO:0046872metal ion bindingIEA
GeneCards PDP1
UniProt Q9P0J1, Q6P1N1
Vega OTTHUMG00000164356
MIM 605993
Ensembl ENSG00000164951
HGNC 9279
HPRD 16185

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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