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PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001161779 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. ORF Sequence $489.81
Peptide Services
Antibody Services
Protein Services
NM_001161780 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA. ORF Sequence $489.81
Peptide Services
Antibody Services
Protein Services
NM_001161781 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), nuclear gene encoding mitochondrial protein, transcript variant 4, mRNA. ORF Sequence $468.06
Peptide Services
Antibody Services
Protein Services
NM_018444 Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), nuclear gene encoding mitochondrial protein, transcript variant 5, mRNA. ORF Sequence $468.06
Peptide Services
Antibody Services
Protein Services


Gene Symbol PDP1
Entrez Gene ID 54704
Full Name pyruvate dehyrogenase phosphatase catalytic subunit 1
Synonyms FLJ32517, FLJ56179, MGC119646, PDH, PDP, PDPC, PPM2C
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q22.1

Summary Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].
Disorder

MIM: 605993

Pyruvate dehydrogenase phosphatase deficiency, 608782 (3)

mRNA Protein Product Sequence Price Select
NM_001161779, 239985421 NP_001155251, 239985422 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 2 Full Length $1530.55
ORF Sequence $489.81
NM_001161780, 239985425 NP_001155252, 239985426 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 2 Full Length $1486.45
ORF Sequence $489.81
NM_001161781, 239985427 NP_001155253, 239985428 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 3 Full Length $1481.90
ORF Sequence $468.06
NM_018444, 239985429 NP_060914, 45439339 pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 3 Full Length $1501.85
ORF Sequence $468.06
WikiPathways
WP78TCA Cycle
Reactome
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
REACT_2071Pyruvate metabolism
REACT_111217Metabolism
REACT_12528Regulation of pyruvate dehydrogenase (PDH) complex
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
Homo sapiens (human)PDP1NP_001155251.1
Pan troglodytes (chimpanzee)PDP1XP_003311895.1
Macaca mulatta (Rhesus monkey)PDP1XP_002805488.1
Canis lupus familiaris (dog)PDP1XP_535129.3
Bos taurus (cattle)PDP1NP_001193282.1
Mus musculus (house mouse)Pdp1NP_001091701.1
Rattus norvegicus (Norway rat)Pdp1NP_062245.2
Gallus gallus (chicken)PDP1NP_001186839.1
Danio rerio (zebrafish)pdp1NP_001104628.1
Drosophila melanogaster (fruit fly)PdpNP_572404.1
Caenorhabditis eleganspdp-1NP_491357.1
GeneCards PDP1
UniProt Q9P0J1, J3KPU0, Q6P1N1
MIM 605993
Ensembl ENSG00000164951
HGNC 9279
HPRD 16185

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
pyruvate dehyrogenase phosphatase catalytic subunit 1
Names
pyruvate dehyrogenase phosphatase catalytic subunit 1
PDP 1
PDPC 1
pyruvate dehydrogenase phosphatase catalytic subunit 1
pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
protein phosphatase 2C, magnesium-dependent, catalytic subunit
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
NP_001155251.1
NP_001155252.1
NP_001155253.1
NP_060914.2

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