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PPAT phosphoribosyl pyrophosphate amidotransferase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002703 Homo sapiens phosphoribosyl pyrophosphate amidotransferase (PPAT), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol PPAT
Entrez Gene ID 5471
Full Name phosphoribosyl pyrophosphate amidotransferase
Synonyms ATASE, GPAT, PRAT
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12

Summary The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011].
Disorder

MIM: 172450

mRNA Protein Product Sequence Price Select
NM_002703, 325296911 NP_002694, 29570798 amidophosphoribosyltransferase proprotein ORF Sequence $550.00
KEGG
hsa00250Alanine, aspartate and glutamate metabolism
hsa00230Purine metabolism
hsa_M00048Inosine monophosphate biosynthesis, PRPP + glutamine => IMP
WikiPathways
WP1601Fluoropyrimidine Activity
BIOCYC
HUMAN_PWY-61215-aminoimidazole ribonucleotide biosynthesis I
HUMAN_PWY-841purine nucleotides de novo biosynthesis II
Reactome
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_522Purine metabolism
REACT_1776Purine ribonucleoside monophosphate biosynthesis
Homo sapiens (human)PPATNP_002694.3
Pan troglodytes (chimpanzee)PPATXP_001140991.1
Macaca mulatta (Rhesus monkey)PPATXP_001085606.1
Canis lupus familiaris (dog)PPATXP_854170.1
Bos taurus (cattle)PPATNP_001095845.1
Mus musculus (house mouse)PpatNP_742158.1
Rattus norvegicus (Norway rat)PpatNP_476546.1
Gallus gallus (chicken)PPATNP_001004401.1
Danio rerio (zebrafish)ppatNP_001076346.2
Drosophila melanogaster (fruit fly)PratNP_524271.2
Drosophila melanogaster (fruit fly)Prat2NP_523949.2
Caenorhabditis elegansCELE_T04A8.5NP_497958.1
Arabidopsis thaliana (thale cress)ASE3NP_195599.1
Arabidopsis thaliana (thale cress)ASE1NP_179247.1
Arabidopsis thaliana (thale cress)ASE2NP_195200.1
GeneCards PPAT
UniProt Q59G63, A8K4H7, Q06203
MIM 172450
Ensembl ENSG00000128059
HGNC 9238
HPRD 01402

General protein information

Preferred Names
amidophosphoribosyltransferase
Names
amidophosphoribosyltransferase
glutamine PRPP amidotransferase
glutamine phosphoribosylpyrophosphate amidotransferase
glutamine phosphoribosylpyrophosphatate amidotransferase
NP_002694.3

Interactant



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