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PPAT phosphoribosyl pyrophosphate amidotransferase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002703 Homo sapiens phosphoribosyl pyrophosphate amidotransferase (PPAT), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol PPAT
Entrez Gene ID 5471
Full Name phosphoribosyl pyrophosphate amidotransferase
Synonyms ATASE, GPAT, PRAT
General protein information
Preferred Names
amidophosphoribosyltransferase
Names
amidophosphoribosyltransferase
glutamine PRPP amidotransferase
glutamine phosphoribosylpyrophosphate amidotransferase
glutamine phosphoribosylpyrophosphatate amidotransferase
NP_002694.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12

Summary The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011].
Disorder

MIM: 172450

mRNA Protein Product Sequence Price Select
NM_002703, 325296911 NP_002694, 29570798 amidophosphoribosyltransferase proprotein ORF Sequence $550.00
KEGG
hsa00230Purine metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa_M00048Inosine monophosphate biosynthesis, PRPP + glutamine => IMP
WikiPathways
WP1601Fluoropyrimidine Activity
BIOCYC
HUMAN_PWY-61215-aminoimidazole ribonucleotide biosynthesis I
HUMAN_PWY-841purine nucleotides de novo biosynthesis II
Reactome
REACT_522Purine metabolism
REACT_1776Purine ribonucleoside monophosphate biosynthesis
REACT_1698Metabolism of nucleotides
REACT_111217Metabolism
Homo sapiens (human)PPATNP_002694.3
Pan troglodytes (chimpanzee)PPATXP_001140991.1
Macaca mulatta (Rhesus monkey)PPATXP_001085606.1
Canis lupus familiaris (dog)PPATXP_854170.1
Bos taurus (cattle)PPATNP_001095845.1
Mus musculus (house mouse)PpatNP_742158.1
Rattus norvegicus (Norway rat)PpatNP_476546.1
Gallus gallus (chicken)PPATNP_001004401.1
Danio rerio (zebrafish)ppatNP_001076346.2
Drosophila melanogaster (fruit fly)Prat2NP_523949.2
Drosophila melanogaster (fruit fly)PratNP_524271.2
Caenorhabditis elegansCELE_T04A8.5NP_497958.1
Arabidopsis thaliana (thale cress)ASE3NP_195599.1
Arabidopsis thaliana (thale cress)ASE1NP_179247.1
Arabidopsis thaliana (thale cress)ASE2NP_195200.1
Xenopus (Silurana) tropicalis (western clawed frog)ppatNP_989313.1
Process
IDNameEvidence
GO:0000082G1/S transition of mitotic cell cycleIEA
GO:0001822kidney developmentIEA
GO:0006144purine nucleobase metabolic processTAS
GO:0006164purine nucleotide biosynthetic processTAS
GO:0006189'de novo' IMP biosynthetic processIEA
GO:0006543glutamine catabolic processIEA
GO:0007595lactationIEA
GO:0009113purine nucleobase biosynthetic processIEA
GO:0009116nucleoside metabolic processIEA
GO:0009168purine ribonucleoside monophosphate biosynthetic processTAS
GO:0031100organ regenerationIEA
GO:0032869cellular response to insulin stimulusIEA
GO:0035690cellular response to drugIEA
GO:0044281small molecule metabolic processTAS
GO:0051289protein homotetramerizationIEA
GO:0055086nucleobase-containing small molecule metabolic processTAS
GO:0060135maternal process involved in female pregnancyIEA
Component
IDNameEvidence
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004044amidophosphoribosyltransferase activityIEA
GO:0046872metal ion bindingIEA
GO:00515394 iron, 4 sulfur cluster bindingIEA
GeneCards PPAT
UniProt Q59G63, A8K4H7, Q06203
Vega OTTHUMG00000128842
MIM 172450
Ensembl ENSG00000128059
HGNC 9238
HPRD 01402

Interactant

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