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CTSA cathepsin A [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000308 Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001127695 Homo sapiens cathepsin A (CTSA), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001167594 Homo sapiens cathepsin A (CTSA), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol CTSA
Entrez Gene ID 5476
Full Name cathepsin A
Synonyms GLB2, GSL, NGBE, PPCA, PPGB
General protein information
Preferred Names
lysosomal protective protein
Names
lysosomal protective protein
deamidase
urinary kininase
carboxypeptidase C
carboxypeptidase L
carboxypeptidase-L
beta-galactosidase 2
lysosomal carboxypeptidase A
protective protein cathepsin A
carboxypeptidase Y-like kininase
beta-galactosidase protective protein
NP_000299.2
NP_001121167.1
NP_001161066.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.1

Summary This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 613111

Galactosialidosis, 256540 (3)

mRNA Protein Product Sequence Price Select
NM_000308, 119395728 NP_000299, 119395729 lysosomal protective protein isoform a precursor ORF Sequence $550.00
NM_001127695, 189163484 NP_001121167, 189163485 lysosomal protective protein isoform b precursor ORF Sequence $550.00
NM_001167594, 262527234 NP_001161066, 262527235 lysosomal protective protein isoform c precursor ORF Sequence $550.00
KEGG
hsa04614Renin-angiotensin system
hsa04142Lysosome
Reactome
REACT_19323Sphingolipid metabolism
REACT_17015Metabolism of proteins
REACT_6900Immune System
REACT_22258Metabolism of lipids and lipoproteins
REACT_22161Post-translational protein modification
REACT_22426Asparagine N-linked glycosylation
REACT_22433Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
REACT_22387Synthesis of substrates in N-glycan biosythesis
REACT_75774Adaptive Immune System
REACT_111217Metabolism
REACT_116105Glycosphingolipid metabolism
REACT_121399MHC class II antigen presentation
REACT_200874Sialic acid metabolism
Homo sapiens (human)CTSANP_000299.2
Pan troglodytes (chimpanzee)CTSAXP_001159669.2
Macaca mulatta (Rhesus monkey)CTSAXP_001106032.1
Canis lupus familiaris (dog)CTSANP_001103385.1
Bos taurus (cattle)CTSANP_001030403.1
Mus musculus (house mouse)CtsaNP_032932.2
Rattus norvegicus (Norway rat)CtsaNP_001011959.1
Gallus gallus (chicken)CTSANP_001026662.1
Danio rerio (zebrafish)ctsaNP_956844.1
Caenorhabditis elegansF13D12.6NP_496507.1
Caenorhabditis elegansF41C3.5NP_494846.1
Arabidopsis thaliana (thale cress)scpl20NP_193027.5
Arabidopsis thaliana (thale cress)scpl21NP_189169.1
Xenopus (Silurana) tropicalis (western clawed frog)ctsaNP_001039207.1
Process
IDNameEvidence
GO:0006508proteolysisIEA
GO:0006665sphingolipid metabolic processTAS
GO:0006687glycosphingolipid metabolic processTAS
GO:0006886intracellular protein transportTAS
GO:0043085positive regulation of catalytic activityTAS
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005764lysosomeNAS
GO:0005783endoplasmic reticulumTAS
GO:0016020membraneIDA
GO:0043202lysosomal lumenTAS
GO:0043231intracellular membrane-bounded organelleIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004180carboxypeptidase activityTAS
GO:0004185serine-type carboxypeptidase activityIEA
GO:0008047enzyme activator activityTAS
GeneCards CTSA
PDB 4CIA, 4AZ3, 3BXN, 3BP4, 4MWT, 4CIB, 1IVY, 4MWS, 4CI9, 3BP7, 4AZ0
UniProt B4E324, P10619, X6R8A1, X6R5C5
Vega OTTHUMG00000033078
MIM 613111
Ensembl ENSG00000064601
HGNC 9251
HPRD 02020

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CTSA gene?

The CTSA gene provides instructions for making a protein called cathepsin A. Cathepsin A can act as a protease, cutting apart other proteins in order to break them down. Cathepsin A can also act as a protective protein, interacting with other enzymes to prevent them from breaking down prematurely. Based on this protective function, this enzyme is also called protective protein/cathepsin A or PPCA.

Cathepsin A is active in cellular compartments called lysosomes. These compartments contain enzymes that digest and recycle materials when they are no longer needed. Cathepsin A interacts with the enzymes β-galactosidase and neuraminidase 1, which play a role in the breakdown of complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins) or fats (glycolipids). Cathepsin A forms a complex with these two enzymes and directs their transport within the cell to the lysosomes. Within lysosomes, cathepsin A activates the enzymes and prevents their breakdown.

On the cell surface, cathepsin A forms a complex with neuraminidase 1 and elastin binding protein, forming the elastin binding protein receptor. This receptor complex plays a role in the formation of elastic fibers, which are a component of the connective tissue that forms the body's supportive framework.

Interactant

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