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PPIB peptidylprolyl isomerase B (cyclophilin B) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19649 NM_000942 Homo sapiens peptidylprolyl isomerase B (cyclophilin B) (PPIB), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19649C NM_000942 Homo sapiens peptidylprolyl isomerase B (cyclophilin B) (PPIB), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PPIB
Entrez Gene ID 5479
Full Name peptidylprolyl isomerase B (cyclophilin B)
Synonyms CYP-S1, CYPB, HEL-S-39, OI9, SCYLP
General protein information
Preferred Names
peptidyl-prolyl cis-trans isomerase B
Names
peptidyl-prolyl cis-trans isomerase B
PPIase B
rotamase B
S-cyclophilin
cyclophilin-like protein
NP_000933.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q21-q22

Summary The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
Disorder

MIM: 123841

Osteogenesis imperfecta, type IX, 259440 (3)

mRNA Protein Product Sequence Price Select
NM_000942, 44890060 NP_000933, 4758950 peptidyl-prolyl cis-trans isomerase B precursor ORF Sequence $159.00
WikiPathways
WP2037Prolactin Signaling Pathway
Pathway Interaction Database
syndecan_1_pathwaySyndecan-1-mediated signaling events
Reactome
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_121139Collagen biosynthesis and modifying enzymes
Homo sapiens (human)PPIBNP_000933.1
Pan troglodytes (chimpanzee)PPIBXP_003952716.1
Macaca mulatta (Rhesus monkey)PPIBXP_001106590.1
Canis lupus familiaris (dog)PPIBXP_852389.1
Bos taurus (cattle)PPIBNP_776577.1
Mus musculus (house mouse)PpibNP_035279.2
Rattus norvegicus (Norway rat)PpibNP_071981.1
Gallus gallus (chicken)PPIBNP_990792.1
Danio rerio (zebrafish)ppibNP_998184.1
Drosophila melanogaster (fruit fly)CG2852NP_611695.1
Caenorhabditis eleganscyn-6NP_497257.1
Caenorhabditis eleganscyn-5NP_493624.1
Arabidopsis thaliana (thale cress)CYP20-2NP_001190299.1
Xenopus (Silurana) tropicalis (western clawed frog)ppibNP_001017063.1
Process
IDNameEvidence
GO:0000413protein peptidyl-prolyl isomerizationISS
GO:0030198extracellular matrix organizationTAS
GO:0040018positive regulation of multicellular organism growthIMP
GO:0050821protein stabilizationIMP
GO:0060348bone developmentIMP
GO:0061077chaperone-mediated protein foldingIDA
GO:0061077chaperone-mediated protein foldingIMP
GO:1901873regulation of post-translational protein modificationIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005783endoplasmic reticulumIDA
GO:0005788endoplasmic reticulum lumenNAS
GO:0005788endoplasmic reticulum lumenTAS
GO:0016020membraneIDA
GO:0032991macromolecular complexISS
GO:0042470melanosomeIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003755peptidyl-prolyl cis-trans isomerase activityISS
GO:0003755peptidyl-prolyl cis-trans isomerase activityNAS
GO:0005515protein bindingIPI
GO:0005518collagen bindingISS
GO:0032403protein complex bindingISS
GO:0042277peptide bindingIEA
GO:0044822poly(A) RNA bindingIDA
GO:0051082unfolded protein bindingTAS
GeneCards PPIB
PDB 3ICH, 3ICI, 1CYN
UniProt P23284
Vega OTTHUMG00000133018
MIM 123841
Ensembl ENSG00000166794
HGNC 9255
HPRD 00458

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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