Sequence in raw or FASTA format:
PPIB peptidylprolyl isomerase B (cyclophilin B) [Homo sapiens (human)]
| Gene Symbol | PPIB |
| Entrez Gene ID | 5479 |
| Full Name | peptidylprolyl isomerase B (cyclophilin B) |
| Synonyms | CYP-S1, CYPB, MGC14109, MGC2224, OI9, SCYLP |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
15 15q21-q22 |
| Summary | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq]. |
| Disorder | MIM: 123841 Osteogenesis imperfecta, type IX, 259440 (3) |
| mRNA | NM_000942, 44890060 |
| Protein | NP_000933, 4758950 |
| Product | peptidyl-prolyl cis-trans isomerase B precursor |
| RefSeq Status | REVIEWED |
| syndecan_1_pathway | Syndecan-1-mediated signaling events |
| Homo sapiens (human) | PPIB | NP_000933.1 |
| Pan troglodytes (chimpanzee) | PPIB | XP_001174161.1 |
| Canis lupus familiaris (dog) | PPIB | XP_852389.1 |
| Bos taurus (cattle) | PPIB | NP_776577.1 |
| Mus musculus (house mouse) | Ppib | NP_035279.2 |
| Rattus norvegicus (Norway rat) | Ppib | NP_071981.1 |
| Gallus gallus (chicken) | PPIB | NP_990792.1 |
| Danio rerio (zebrafish) | ppib | NP_998184.1 |
| Drosophila melanogaster (fruit fly) | CG2852 | NP_611695.1 |
| Caenorhabditis elegans | cyn-5 | NP_493624.1 |
| Caenorhabditis elegans | cyn-6 | NP_497257.1 |
| Arabidopsis thaliana (thale cress) | AT5G13120 | NP_196816.1 |
| ID | Name | Evidence |
| GO:0000413 | protein peptidyl-prolyl isomerization | NAS |
| GO:0006457 | protein folding | IEA |
Component
| ID | Name | Evidence |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005788 | endoplasmic reticulum lumen | NAS |
| GO:0042470 | melanosome | IEA |
Function
| ID | Name | Evidence |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | NAS |
| GO:0005515 | protein binding | IPI |
| GO:0016853 | isomerase activity | IEA |
| GO:0042277 | peptide binding | IEA |
| GO:0051082 | unfolded protein binding | TAS |
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