• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PPP2R1A protein phosphatase 2, regulatory subunit A, alpha [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_014225 Homo sapiens protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

*Business Day

Related Services

Gene Symbol PPP2R1A
Entrez Gene ID 5518
Full Name protein phosphatase 2, regulatory subunit A, alpha
Synonyms PP2A-Aalpha, PP2AAALPHA, PR65A
General protein information
Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
PP2A subunit A isoform R1-alpha
PP2A subunit A isoform PR65-alpha
medium tumor antigen-associated 61 KDA protein
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
NP_055040.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.41

Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
Disorder

MIM: 605983

mRNA Protein Product Sequence Price Select
NM_014225, 294774554 NP_055040, 21361399 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform ORF Sequence $490.00
KEGG
hsa04350TGF-beta signaling pathway
hsa04530Tight junction
hsa04730Long-term depression
hsa05142Chagas disease (American trypanosomiasis)
hsa04114Oocyte meiosis
hsa05160Hepatitis C
hsa03015mRNA surveillance pathway
hsa04728Dopaminergic synapse
hsa04151PI3K-Akt signaling pathway
hsa04390Hippo signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04152AMPK signaling pathway
WikiPathways
WP399Wnt Signaling Pathway and Pluripotency
WP500Glycogen Metabolism
WP364IL-6 Signaling Pathway
Pathway Interaction Database
plk1_pathwayPLK1 signaling events
wnt_canonical_pathwayCanonical Wnt signaling pathway
erbb1_downstream_pathwayErbB1 downstream signaling
Reactome
REACT_152Cell Cycle, Mitotic
REACT_1783G1/S Transition
REACT_471E2F mediated regulation of DNA replication
REACT_765Mitotic Prophase
REACT_2203G2/M Transition
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_682Mitotic Prometaphase
REACT_15479Centrosome maturation
REACT_1275Mitotic Anaphase
REACT_1590G1 Phase
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_329Inhibition of replication initiation of damaged DNA by RB1/E2F1
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_910M Phase
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_821Cyclin D associated events in G1
REACT_15451Loss of proteins required for interphase microtubule organization####from the centrosome
REACT_71Gene Expression
REACT_1383Glycolysis
REACT_604Hemostasis
REACT_705PP2A-mediated dephosphorylation of key metabolic factors
REACT_1505Integration of energy metabolism
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_9470Signaling by FGFR
REACT_14797Signaling by GPCR
REACT_6966Toll-Like Receptors Cascades
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6809MyD88-independent cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_11061Signalling by NGF
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_11045Signaling by Wnt
REACT_15334DARPP-32 events
REACT_11065Beta-catenin phosphorylation cascade
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_12436ERKs are inactivated
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_12599ERK/MAPK targets
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_75774Adaptive Immune System
REACT_75886Nonsense-Mediated Decay (NMD)
REACT_75822Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
REACT_23879Platelet sensitization by LDL
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_23876Platelet homeostasis
REACT_111080Spry regulation of FGF signaling
REACT_111217Metabolism
REACT_111184Negative regulation of FGFR signaling
REACT_111102Signal Transduction
REACT_116125Disease
REACT_115566Cell Cycle
REACT_120736Signaling by FGFR in disease
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_150314Mitotic Metaphase and Anaphase
REACT_150182MASTL Facilitates Mitotic Progression
REACT_150471Separation of Sister Chromatids
REACT_160242Initiation of Nuclear Envelope Reformation
REACT_160113Nuclear Envelope Reassembly
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
REACT_200777TCF dependent signaling in response to WNT
REACT_200610disassembly of the destruction complex and recruitment of AXIN to the membrane
Homo sapiens (human)PPP2R1ANP_055040.2
Pan troglodytes (chimpanzee)PPP2R1AXP_001174546.1
Macaca mulatta (Rhesus monkey)PPP2R1AXP_001116604.1
Canis lupus familiaris (dog)LOC484335XP_850993.1
Bos taurus (cattle)PPP2R1ANP_001032554.1
Mus musculus (house mouse)Ppp2r1aNP_058587.1
Rattus norvegicus (Norway rat)Ppp2r1aNP_476481.1
Drosophila melanogaster (fruit fly)Pp2A-29BNP_001027225.1
Caenorhabditis eleganspaa-1NP_498162.2
Arabidopsis thaliana (thale cress)RCN1NP_173920.1
Xenopus (Silurana) tropicalis (western clawed frog)ppp2r1aNP_989405.1
Process
IDNameEvidence
GO:0000086G2/M transition of mitotic cell cycleTAS
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTAS
GO:0000188inactivation of MAPK activityNAS
GO:0000278mitotic cell cycleTAS
GO:0006275regulation of DNA replicationNAS
GO:0006355regulation of transcription, DNA-templatedNAS
GO:0006461protein complex assemblyTAS
GO:0006470protein dephosphorylationTAS
GO:0006672ceramide metabolic processNAS
GO:0006915apoptotic processTAS
GO:0007059chromosome segregationIDA
GO:0007084mitotic nuclear envelope reassemblyTAS
GO:0008380RNA splicingNAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010033response to organic substanceNAS
GO:0010467gene expressionTAS
GO:0016070RNA metabolic processTAS
GO:0016071mRNA metabolic processTAS
GO:0019932second-messenger-mediated signalingNAS
GO:0030111regulation of Wnt signaling pathwayNAS
GO:0030155regulation of cell adhesionNAS
GO:0030308negative regulation of cell growthNAS
GO:0040008regulation of growthNAS
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 proteinNAS
GO:0045595regulation of cell differentiationNAS
GO:0070262peptidyl-serine dephosphorylationIEA
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA
Component
IDNameEvidence
GO:0000159protein phosphatase type 2A complexIDA
GO:0000159protein phosphatase type 2A complexTAS
GO:0000775chromosome, centromeric regionIDA
GO:0005634nucleusNAS
GO:0005739mitochondrionNAS
GO:0005829cytosolTAS
GO:0015630microtubule cytoskeletonNAS
GO:0016020membraneNAS
Function
IDNameEvidence
GO:0003823antigen bindingIPI
GO:0004722protein serine/threonine phosphatase activityIEA
GO:0005515protein bindingIPI
GO:0008601protein phosphatase type 2A regulator activityTAS
GO:0046982protein heterodimerization activityIPI
GeneCards PPP2R1A
PDB 2PKG, 2NYL, 4I5N, 3DW8, 4LAC, 1B3U, 2IE3, 3C5W, 4I5L, 2IE4, 3K7W, 2NPP, 2NYM, 3K7V
UniProt A8K7B7, P30153
MIM 605983
HGNC 9302
HPRD 16184

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.