ACER3 alkaline ceramidase 3 [Homo sapiens (human)]
| Gene Symbol | ACER3 |
| Entrez Gene ID | 55331 |
| Full Name | alkaline ceramidase 3 |
| Synonyms | APHC, FLJ11238, PHCA |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
11 11q13.5 |
| Summary | |
| Disorder | MIM: |
| mRNA | NM_018367, 170932466 |
| Protein | NP_060837, 170932467 |
| Product | alkaline ceramidase 3 |
| RefSeq Status | VALIDATED |
| hsa00600 | Sphingolipid metabolism |
Reactome
| REACT_19323 | Sphingolipid metabolism |
| REACT_22258 | Metabolism of lipids and lipoproteins |
| Homo sapiens (human) | ACER3 | NP_060837.3 |
| Pan troglodytes (chimpanzee) | ACER3 | XP_001175032.1 |
| Canis lupus familiaris (dog) | ACER3 | XP_849760.1 |
| Bos taurus (cattle) | ACER3 | NP_001095755.1 |
| Mus musculus (house mouse) | Acer3 | NP_079684.2 |
| Rattus norvegicus (Norway rat) | Acer3 | XP_574497.1 |
| Gallus gallus (chicken) | PHCA | XP_417279.1 |
| Danio rerio (zebrafish) | LOC555411 | XP_683002.4 |
| Arabidopsis thaliana (thale cress) | ATCES1 | NP_567660.1 |
| ID | Name | Evidence |
| GO:0006665 | sphingolipid metabolic process | TAS |
| GO:0006672 | ceramide metabolic process | IEA |
| GO:0008284 | positive regulation of cell proliferation | IMP |
| GO:0046512 | sphingosine biosynthetic process | IDA |
| GO:0071602 | phytosphingosine biosynthetic process | IDA |
Component
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | IEA |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005789 | endoplasmic reticulum membrane | EXP |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
| GO:0030173 | integral to Golgi membrane | IDA |
| GO:0030176 | integral to endoplasmic reticulum membrane | IDA |
Function
| ID | Name | Evidence |
| GO:0016787 | hydrolase activity | IEA |
| GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | IEA |
| GO:0070774 | phytoceramidase activity | EXP |
| GO:0070774 | phytoceramidase activity | IDA |
| GeneCards | ACER3 |
| UniProt | Q9NUN7 |
| Ensembl | ENSG00000078124 |
| HGNC | 16066 |
| HPRD | 17844 |
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