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PRKACA protein kinase, cAMP-dependent, catalytic, alpha [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17314 NM_207518 Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18669 NM_002730 Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu51697 XM_005259984 PREDICTED: Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17314C NM_207518 Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu18669C NM_002730 Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu51697C XM_005259984 PREDICTED: Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol PRKACA
Entrez Gene ID 5566
Full Name protein kinase, cAMP-dependent, catalytic, alpha
Synonyms PKACA
General protein information
Preferred Names
cAMP-dependent protein kinase catalytic subunit alpha
Names
cAMP-dependent protein kinase catalytic subunit alpha
PKA C-alpha
protein kinase A catalytic subunit
cAMP-dependent protein kinase catalytic subunit alpha, isoform 1
NP_002721.1
NP_997401.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.1

Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601639

mRNA Protein Product Sequence Price Select
NM_002730, 46909581 NP_002721, 4506055 cAMP-dependent protein kinase catalytic subunit alpha isoform 1 ORF Sequence $269.00
NM_207518, 46909583 NP_997401, 46909584 cAMP-dependent protein kinase catalytic subunit alpha isoform 2 ORF Sequence $400.00
XM_005259984, 530415007 XP_005260041, 530415008 cAMP-dependent protein kinase catalytic subunit alpha isoform X1 ORF Sequence $550.00
KEGG
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04010MAPK signaling pathway
hsa04210Apoptosis
hsa04720Long-term potentiation
hsa04742Taste transduction
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04740Olfactory transduction
hsa04912GnRH signaling pathway
hsa05110Vibrio cholerae infection
hsa05012Parkinson's disease
hsa04540Gap junction
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa05020Prion diseases
hsa04914Progesterone-mediated oocyte maturation
hsa05414Dilated cardiomyopathy
hsa04962Vasopressin-regulated water reabsorption
hsa04114Oocyte meiosis
hsa05146Amoebiasis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa05166HTLV-I infection
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04976Bile secretion
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05205Proteoglycans in cancer
hsa04713Circadian entrainment
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa04915Estrogen signaling pathway
hsa05034Alcoholism
hsa05169Epstein-Barr virus infection
hsa05032Morphine addiction
hsa05203Viral carcinogenesis
hsa04918Thyroid hormone synthesis
hsa04913Ovarian steroidogenesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04911Insulin secretion
hsa04919Thyroid hormone signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04611Platelet activation
hsa04014Ras signaling pathway
WikiPathways
WP382MAPK signaling pathway
WP289Myometrial Relaxation and Contraction Pathways
WP474Endochondral Ossification
WP1982SREBP signalling
WP666Hypothetical Network for Drug Addiction
WP1602Nicotine Activity on Dopaminergic Neurons
WP712Estrogen signaling pathway
WP35G Protein Signaling Pathways
WP286IL-3 Signaling Pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP706SIDS Susceptibility Pathways
WP536Calcium Regulation in the Cardiac Cell
WP2012miRs in Muscle Cell Differentiation
WP2035FSH signaling pathway
WP2038Regulation of Microtubule Cytoskeleton
WP2436Dopamine metabolism
Pathway Interaction Database
aurora_a_pathwayAurora A signaling
vegfr1_pathwayVEGFR1 specific signals
tcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
lpa4_pathwayLPA4-mediated signaling events
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
hdac_classi_pathwaySignaling events mediated by HDAC Class I
erbb2erbb3pathwayErbB2/ErbB3 signaling events
ret_pathwaySignaling events regulated by Ret tyrosine kinase
lkb1_pathwayLKB1 signaling events
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
reg_gr_pathwayGlucocorticoid receptor regulatory network
a4b1_paxdep_pathwayPaxillin-dependent events mediated by a4b1
retinoic_acid_pathwayRetinoic acid receptors-mediated signaling
syndecan_1_pathwaySyndecan-1-mediated signaling events
txa2pathwayThromboxane A2 receptor signaling
syndecan_2_pathwaySyndecan-2-mediated signaling events
Reactome
REACT_152Cell Cycle, Mitotic
REACT_2203G2/M Transition
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15479Centrosome maturation
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization####from the centrosome
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_18325Regulation of insulin secretion
REACT_604Hemostasis
REACT_1665Glucagon signaling in metabolic regulation
REACT_1525PKA-mediated phosphorylation of key metabolic factors
REACT_602Lipid digestion, mobilization, and transport
REACT_1505Integration of energy metabolism
REACT_1946PKA activation in glucagon signalling
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_494Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_1520Gluconeogenesis
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_9470Signaling by FGFR
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_16888Signaling by PDGF
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15530PKA activation
REACT_9053CaM pathway
REACT_15497PKA-mediated phosphorylation of CREB
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_12079PLC-gamma1 signalling
REACT_15426PLC beta mediated events
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_9000Calmodulin induced events
REACT_15334DARPP-32 events
REACT_15518Transmembrane transport of small molecules
REACT_15307Ca-dependent events
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_22232Signaling by Interleukins
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_22258Metabolism of lipids and lipoproteins
REACT_21391Mitotic G2-G2/M phases
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_20593Post NMDA receptor activation events
REACT_20625CREB phosphorylation through the activation of Adenylate Cyclase
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_23898Rap1 signalling
REACT_24023Regulation of water balance by renal Aquaporins
REACT_23887Aquaporin-mediated transport
REACT_111064DAG and IP3 signaling
REACT_111217Metabolism
REACT_111102Signal Transduction
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116125Disease
REACT_115566Cell Cycle
REACT_115720PLCG1 events in ERBB2 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_120736Signaling by FGFR in disease
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)PRKACANP_002721.1
Pan troglodytes (chimpanzee)PRKACAXP_001171437.1
Canis lupus familiaris (dog)PRKACANP_001003032.1
Bos taurus (cattle)PRKACANP_777009.1
Mus musculus (house mouse)PrkacaNP_032880.1
Rattus norvegicus (Norway rat)PrkacaNP_001094392.1
Danio rerio (zebrafish)prkacabNP_001003470.1
Xenopus (Silurana) tropicalis (western clawed frog)prkacaNP_001016403.1
Process
IDNameEvidence
GO:0000086G2/M transition of mitotic cell cycleTAS
GO:0000278mitotic cell cycleTAS
GO:0001707mesoderm formationIEA
GO:0002027regulation of heart rateTAS
GO:0005975carbohydrate metabolic processTAS
GO:0006006glucose metabolic processTAS
GO:0006094gluconeogenesisTAS
GO:0006112energy reserve metabolic processTAS
GO:0006468protein phosphorylationNAS
GO:0006833water transportTAS
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007202activation of phospholipase C activityTAS
GO:0007596blood coagulationTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionTAS
GO:0018105peptidyl-serine phosphorylationIDA
GO:0019433triglyceride catabolic processTAS
GO:0034199activation of protein kinase A activityTAS
GO:0035556intracellular signal transductionTAS
GO:0035584calcium-mediated signaling using intracellular calcium sourceTAS
GO:0043393regulation of protein bindingTAS
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0045667regulation of osteoblast differentiationIDA
GO:0046777protein autophosphorylationIEA
GO:0046827positive regulation of protein export from nucleusIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048240sperm capacitationISS
GO:0050796regulation of insulin secretionTAS
GO:0050804regulation of synaptic transmissionIEA
GO:0051480cytosolic calcium ion homeostasisTAS
GO:0055085transmembrane transportTAS
GO:0055117regulation of cardiac muscle contractionTAS
GO:0060314regulation of ryanodine-sensitive calcium-release channel activityTAS
GO:0061136regulation of proteasomal protein catabolic processIDA
GO:0071158positive regulation of cell cycle arrestISS
GO:0071333cellular response to glucose stimulusIDA
GO:0071374cellular response to parathyroid hormone stimulusIEA
GO:0071377cellular response to glucagon stimulusTAS
GO:0071872cellular response to epinephrine stimulusTAS
GO:0086064cell communication by electrical coupling involved in cardiac conductionTAS
GO:2000810regulation of tight junction assemblyIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005739mitochondrionIEA
GO:0005813centrosomeIDA
GO:0005829cytosolTAS
GO:0005886plasma membraneIEA
GO:0005929ciliumIEA
GO:0005952cAMP-dependent protein kinase complexNAS
GO:0016020membraneIDA
GO:0031588AMP-activated protein kinase complexIDA
GO:0031594neuromuscular junctionIEA
GO:0034704calcium channel complexTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0097225sperm midpieceIDA
Function
IDNameEvidence
GO:0004691cAMP-dependent protein kinase activityIDA
GO:0004691cAMP-dependent protein kinase activityISS
GO:0004691cAMP-dependent protein kinase activityNAS
GO:0004712protein serine/threonine/tyrosine kinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019901protein kinase bindingIPI
GO:0031625ubiquitin protein ligase bindingIDA
GO:0034237protein kinase A regulatory subunit bindingIPI
GeneCards PRKACA
UniProt P17612
Vega OTTHUMG00000182051
MIM 601639
Ensembl ENSG00000072062
HGNC 9380
HPRD 03382

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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