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PRKACA protein kinase, cAMP-dependent, catalytic, alpha [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002730 Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 1, mRNA. ORF Sequence $306.24
Peptide Services
Antibody Services
Protein Services
NM_207518 Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 2, mRNA. ORF Sequence $299.28
Peptide Services
Antibody Services
Protein Services


Gene Symbol PRKACA
Entrez Gene ID 5566
Full Name protein kinase, cAMP-dependent, catalytic, alpha
Synonyms MGC102831, MGC48865, PKACA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.1

Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601639

mRNA Protein Product Sequence Price Select
NM_002730, 46909581 NP_002721, 4506055 cAMP-dependent protein kinase catalytic subunit alpha isoform 1 Full Length $779.81
ORF Sequence $306.24
NM_207518, 46909583 NP_997401, 46909584 cAMP-dependent protein kinase catalytic subunit alpha isoform 2 Full Length $722.10
ORF Sequence $299.28
KEGG
hsa04912GnRH signaling pathway
hsa04725Cholinergic synapse
hsa04914Progesterone-mediated oocyte maturation
hsa04742Taste transduction
hsa04962Vasopressin-regulated water reabsorption
hsa05166HTLV-I infection
hsa04727GABAergic synapse
hsa04010MAPK signaling pathway
hsa04540Gap junction
hsa05030Cocaine addiction
hsa04723Retrograde endocannabinoid signaling
hsa04020Calcium signaling pathway
hsa05169Epstein-Barr virus infection
hsa04062Chemokine signaling pathway
hsa04340Hedgehog signaling pathway
hsa04910Insulin signaling pathway
hsa04971Gastric acid secretion
hsa05032Morphine addiction
hsa04114Oocyte meiosis
hsa05414Dilated cardiomyopathy
hsa04740Olfactory transduction
hsa04728Dopaminergic synapse
hsa04970Salivary secretion
hsa04310Wnt signaling pathway
hsa04210Apoptosis
hsa05203Viral carcinogenesis
hsa04976Bile secretion
hsa05146Amoebiasis
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04713Circadian entrainment
hsa05031Amphetamine addiction
hsa04726Serotonergic synapse
hsa04720Long-term potentiation
hsa04270Vascular smooth muscle contraction
hsa05020Prion diseases
hsa05110Vibrio cholerae infection
hsa05034Alcoholism
hsa04724Glutamatergic synapse
hsa04916Melanogenesis
Pathway Interaction Database
lpa4_pathwayLPA4-mediated signaling events
syndecan_1_pathwaySyndecan-1-mediated signaling events
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
hdac_classi_pathwaySignaling events mediated by HDAC Class I
retinoic_acid_pathwayRetinoic acid receptors-mediated signaling
ret_pathwaySignaling events regulated by Ret tyrosine kinase
syndecan_2_pathwaySyndecan-2-mediated signaling events
aurora_a_pathwayAurora A signaling
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
reg_gr_pathwayGlucocorticoid receptor regulatory network
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
vegfr1_pathwayVEGFR1 specific signals
erbb2erbb3pathwayErbB2/ErbB3 signaling events
a4b1_paxdep_pathwayPaxillin-dependent events mediated by a4b1
lkb1_pathwayLKB1 signaling events
tcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
txa2pathwayThromboxane A2 receptor signaling
WikiPathways
WP474Endochondral Ossification
WP35G Protein Signaling Pathways
WP382MAPK signaling pathway
WP286IL-3 Signaling Pathway
WP536Calcium Regulation in the Cardiac Cell
WP712Estrogen signaling pathway
WP2035FSH signaling pathway
WP289Myometrial Relaxation and Contraction Pathways
WP231TNF-alpha/NF-kB Signaling Pathway
WP2012miRs in Muscle Cell Differentiation
WP666Hypothetical Network for Drug Addiction
WP706SIDS Susceptibility Pathways
WP1602Nicotine Activity on Dopaminergic Neurons
Reactome
REACT_23898Rap1 signalling
REACT_111217Metabolism
REACT_15530PKA activation
REACT_17025Downstream signal transduction
REACT_2203G2/M Transition
REACT_115566Cell Cycle
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15426PLC beta mediated events
REACT_15451Loss of proteins required for interphase microtubule organization####from the centrosome
REACT_1525PKA-mediated phosphorylation of key metabolic factors
REACT_18274Regulation of Insulin Secretion by Glucagon-like Peptide-1
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_9470Signaling by FGFR
REACT_24023Regulation of Water Balance by Renal Aquaporins
REACT_1505Integration of energy metabolism
REACT_15526G-protein mediated events
REACT_111102Signal Transduction
REACT_116125Disease
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21310Phospholipase C-mediated cascade
REACT_9053CaM pathway
REACT_604Hemostasis
REACT_9417Signaling by EGFR
REACT_21391Mitotic G2-G2/M phases
REACT_15497PKA-mediated phosphorylation of CREB
REACT_15334DARPP-32 events
REACT_6802Innate Immune System
REACT_15295Opioid Signalling
REACT_18325Regulation of Insulin Secretion
REACT_22258Metabolism of lipids and lipoproteins
REACT_15479Centrosome maturation
REACT_147814DAP12 signaling
REACT_602Lipid digestion, mobilization, and transport
REACT_147694DAP12 interactions
REACT_11061Signalling by NGF
REACT_16888Signaling by PDGF
REACT_9000Calmodulin induced events
REACT_494Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_6900Immune System
REACT_120736Signaling by FGFR in disease
REACT_21272Downstream signaling of activated FGFR
REACT_75774Adaptive Immune System
REACT_474Metabolism of carbohydrates
REACT_115720PLCG1 events in ERBB2 signaling
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_15307Ca-dependent events
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_152Cell Cycle, Mitotic
REACT_23887Aquaporin-mediated transport
REACT_1520Gluconeogenesis
REACT_15518Transmembrane transport of small molecules
REACT_14797Signaling by GPCR
REACT_111064DAG and IP3 signaling
REACT_723Glucose metabolism
REACT_115871Signaling by EGFR in Cancer
REACT_1665Glucagon signaling in metabolic regulation
REACT_1946PKA activation in glucagon signalling
REACT_12079PLC-gamma1 signalling
REACT_115755Signaling by ERBB2
Homo sapiens (human)PRKACANP_002721.1
Pan troglodytes (chimpanzee)PRKACAXP_001171457.1
Canis lupus familiaris (dog)PRKACANP_001003032.1
Bos taurus (cattle)PRKACANP_777009.1
Mus musculus (house mouse)PrkacaNP_032880.1
Rattus norvegicus (Norway rat)PrkacaNP_001094392.1
Danio rerio (zebrafish)prkacaaNP_001076309.1
Caenorhabditis eleganskin-1NP_740954.1
GeneCards PRKACA
PDB 3AMA, 4AE6, 3L9N, 3OVV, 3AGL, 3MVJ, 3POO, 4AE9, 3L9M, 3NX8, 3VQH, 2GU8, 3AMB, 3P0M, 3AGM, 3L9L, 3OWP, 3OOG, 3OXT
UniProt P17612
MIM 601639
Ensembl ENSG00000072062
HGNC 9380
HPRD 03382

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cAMP-dependent protein kinase catalytic subunit alpha
Names
cAMP-dependent protein kinase catalytic subunit alpha
PKA C-alpha
protein kinase A catalytic subunit
cAMP-dependent protein kinase catalytic subunit alpha, isoform 1
NP_002721.1
NP_997401.1

Interactant

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