Sequence in raw or FASTA format:
POLR3B polymerase (RNA) III (DNA directed) polypeptide B [
Homo sapiens (human)]
Gene Symbol POLR3B
Entrez Gene ID
Full Name polymerase (RNA) III (DNA directed) polypeptide B
Synonyms C128, HLD8, RPC2
General protein information
DNA-directed RNA polymerase III subunit RPC2
DNA-directed RNA polymerase III subunit RPC2
RNA polymerase III subunit C2
DNA-directed RNA polymerase III subunit B
DNA-directed RNA polymerase III 127.6 kDa polypeptide
Gene Type protein-coding
Homo sapiens (human)
Chromosome:12 Map Location:12q23.3
Summary This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
WP405 Eukaryotic Transcription Initiation
REACT_71 Gene Expression
REACT_6900 Immune System
REACT_6802 Innate Immune System
REACT_1371 RNA Polymerase III Transcription
REACT_281 RNA Polymerase III Transcription Initiation
REACT_571 RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_756 RNA Polymerase III Chain Elongation
REACT_347 RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_1036 RNA Polymerase III Transcription Initiation From Type 2 Promoter
REACT_63 RNA Polymerase III Transcription Termination
REACT_22339 RNA Polymerase III Abortive And Retractive Initiation
REACT_21352 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_118823 Cytosolic sensors of pathogen-associated DNA
ID Name Evidence
GO:0006383 transcription from RNA polymerase III promoter TAS
GO:0006385 transcription elongation from RNA polymerase III promoter TAS
GO:0006386 termination of RNA polymerase III transcription TAS
GO:0010467 gene expression TAS
GO:0032481 positive regulation of type I interferon production TAS
GO:0032728 positive regulation of interferon-beta production IMP
GO:0045087 innate immune response TAS
GO:0045089 positive regulation of innate immune response IMP
GO:0051607 defense response to virus IEA
Related articles in PubMed INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity. Yunlei Z, et al. Mol Cell Biochem, 2013 Feb. PMID 23124897. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629. Genome-wide association study of Tourette's syndrome. Scharf JM, et al. Mol Psychiatry, 2013 Jun. PMID 22889924. Pol III-Related Leukodystrophies Bernard G, et al. , 1993. PMID 22855961. Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy. Tétreault M, et al. Am J Hum Genet, 2011 Nov 11. PMID 22036172. See all (23) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
study reports INMAP is a truncated version of POLR3B, and is up-regulated in several human cancer cell lines; results suggest that INMAP may function through the p53 and AP-1 pathways, providing a possible link of its activity with tumourigenesis
Title: INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.
Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy
Title: Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy.
Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy
Title: Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy.
Results suggest that INMAP is a novel protein that plays essential role in spindle formation and cell-cycle progression.
Title: Identification and characterization of INMAP, a novel interphase nucleus and mitotic apparatus protein that is involved in spindle formation and cell cycle progression.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Data describe the purification and identification of RNA polymerase III subunits RPC2 and RPC5.
Title: Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.
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