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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


POLR3B polymerase (RNA) III (DNA directed) polypeptide B [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22699 NM_001160708 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu27279 NM_018082 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu46692 XM_006719498 PREDICTED: Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu22699C NM_001160708 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B), transcript variant 2, mRNA. Customized vector On-demand 25 $1699.00
OHu27279C NM_018082 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B), transcript variant 1, mRNA. Customized vector On-demand 25 $1699.00
OHu46692C XM_006719498 PREDICTED: Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol POLR3B
Entrez Gene ID 55703
Full Name polymerase (RNA) III (DNA directed) polypeptide B
Synonyms C128, HLD8, RPC2
General protein information
Preferred Names
DNA-directed RNA polymerase III subunit RPC2
Names
DNA-directed RNA polymerase III subunit RPC2
RNA polymerase III subunit C2
DNA-directed RNA polymerase III subunit B
DNA-directed RNA polymerase III 127.6 kDa polypeptide
NP_001154180.1
NP_060552.4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q23.3

Summary This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Disorder

MIM: 614366

mRNA Protein Product Sequence Price Select
NM_001160708, 238908504 NP_001154180, 238908505 DNA-directed RNA polymerase III subunit RPC2 isoform 2 ORF Sequence $1500.00
NM_018082, 238908502 NP_060552, 238908503 DNA-directed RNA polymerase III subunit RPC2 isoform 1 ORF Sequence $1500.00
XM_006719498, 578823973 XP_006719561, 578823974 DNA-directed RNA polymerase III subunit RPC2 isoform X1 ORF Sequence $750.00
KEGG
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa03020RNA polymerase
hsa04623Cytosolic DNA-sensing pathway
hsa_M00181RNA polymerase III, eukaryotes
hsa05169Epstein-Barr virus infection
WikiPathways
WP405Eukaryotic Transcription Initiation
Reactome
REACT_71Gene Expression
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1371RNA Polymerase III Transcription
REACT_281RNA Polymerase III Transcription Initiation
REACT_571RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_756RNA Polymerase III Chain Elongation
REACT_347RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_1036RNA Polymerase III Transcription Initiation From Type 2 Promoter
REACT_63RNA Polymerase III Transcription Termination
REACT_22339RNA Polymerase III Abortive And Retractive Initiation
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_118823Cytosolic sensors of pathogen-associated DNA
Homo sapiens (human)POLR3BNP_060552.4
Pan troglodytes (chimpanzee)POLR3BXP_001161567.1
Macaca mulatta (Rhesus monkey)POLR3BXP_001099515.1
Canis lupus familiaris (dog)POLR3BXP_531760.2
Bos taurus (cattle)POLR3BNP_001179718.1
Mus musculus (house mouse)Polr3bNP_081699.1
Rattus norvegicus (Norway rat)Polr3bNP_001178807.1
Gallus gallus (chicken)POLR3BXP_416307.3
Danio rerio (zebrafish)polr3bXP_690811.2
Drosophila melanogaster (fruit fly)RpIII128NP_523706.1
Caenorhabditis elegansF09F7.3NP_498192.2
Arabidopsis thaliana (thale cress)NRPC2NP_199327.4
Xenopus (Silurana) tropicalis (western clawed frog)polr3bNP_001121521.1
Process
IDNameEvidence
GO:0006383transcription from RNA polymerase III promoterTAS
GO:0006385transcription elongation from RNA polymerase III promoterTAS
GO:0006386termination of RNA polymerase III transcriptionTAS
GO:0010467gene expressionTAS
GO:0032481positive regulation of type I interferon productionTAS
GO:0032728positive regulation of interferon-beta productionIMP
GO:0045087innate immune responseTAS
GO:0045089positive regulation of innate immune responseIMP
GO:0051607defense response to virusIEA
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005666DNA-directed RNA polymerase III complexIDA
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0003899DNA-directed RNA polymerase activityIEA
GO:0032549ribonucleoside bindingIEA
GO:0046872metal ion bindingIEA
GeneCards POLR3B
UniProt Q9NW08, Q7Z3R8
Vega OTTHUMG00000170077
MIM 614366
Ensembl ENSG00000013503
HGNC 30348
HPRD 11447

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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