Sequence in raw or FASTA format:
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) [Homo sapiens (human)]
| Gene Symbol | VPS35 |
| Entrez Gene ID | 55737 |
| Full Name | vacuolar protein sorting 35 homolog (S. cerevisiae) |
| Synonyms | DKFZp434E1211, DKFZp434P1672, FLJ10752, FLJ13588, FLJ20388, MEM3 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
16 16q12 |
| Summary | This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq]. |
| Disorder | MIM: 601501 |
| mRNA | NM_018206, 156602659 |
| Protein | NP_060676, 17999541 |
| Product | vacuolar protein sorting-associated protein 35 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | VPS35 | NP_060676.2 |
| Pan troglodytes (chimpanzee) | VPS35 | XP_001161439.1 |
| Canis lupus familiaris (dog) | VPS35 | XP_532570.2 |
| Bos taurus (cattle) | VPS35 | NP_001039723.1 |
| Mus musculus (house mouse) | Vps35 | NP_075373.1 |
| Rattus norvegicus (Norway rat) | Vps35 | XP_214646.3 |
| Gallus gallus (chicken) | VPS35 | NP_001005842.1 |
| Danio rerio (zebrafish) | vps35 | NP_001020688.2 |
| Drosophila melanogaster (fruit fly) | Vps35 | NP_611651.4 |
| Caenorhabditis elegans | vps-35 | NP_495180.2 |
| Arabidopsis thaliana (thale cress) | VPS35B | NP_177713.3 |
| ID | Name | Evidence |
| GO:0015031 | protein transport | IEA |
| GO:0042147 | retrograde transport, endosome to Golgi | NAS |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005768 | endosome | IDA |
| GO:0005829 | cytosol | IDA |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GeneCards | VPS35 |
| MIM | 601501 |
| Ensembl | ENSG00000069329 |
| HGNC | 13487 |
| HPRD | 06085 |
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