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VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18510 NM_018206 Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu49428 XM_005256045 PREDICTED: Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu18510C NM_018206 Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA. Customized vector On-demand 12-14 $329.00
OHu49428C XM_005256045 PREDICTED: Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol VPS35
Entrez Gene ID 55737
Full Name vacuolar protein sorting 35 homolog (S. cerevisiae)
Synonyms MEM3, PARK17
General protein information
Preferred Names
vacuolar protein sorting-associated protein 35
Names
vacuolar protein sorting-associated protein 35
hVPS35
maternal-embryonic 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q12

Summary This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601501

mRNA Protein Product Sequence Price Select
NM_018206, 156602659 NP_060676, 17999541 vacuolar protein sorting-associated protein 35 ORF Sequence $750.00
XM_005256045, 530424104 XP_005256102, 530424105 vacuolar protein sorting-associated protein 35 isoform X2 ORF Sequence $700.00
Reactome
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_163710WNT ligand biogenesis and trafficking
Homo sapiens (human)VPS35NP_060676.2
Pan troglodytes (chimpanzee)VPS35XP_001161536.1
Macaca mulatta (Rhesus monkey)VPS35XP_001108828.2
Canis lupus familiaris (dog)VPS35XP_532570.3
Bos taurus (cattle)VPS35NP_001039723.1
Mus musculus (house mouse)Vps35NP_075373.1
Rattus norvegicus (Norway rat)Vps35NP_001099188.2
Gallus gallus (chicken)VPS35NP_001005842.1
Danio rerio (zebrafish)vps35NP_001020688.2
Drosophila melanogaster (fruit fly)Vps35NP_611651.4
Caenorhabditis elegansvps-35NP_495180.2
Arabidopsis thaliana (thale cress)VPS35BNP_177713.3
Process
IDNameEvidence
GO:0008219cell deathIEA
GO:0015031protein transportIEA
GO:0042147retrograde transport, endosome to GolgiNAS
Component
IDNameEvidence
GO:0005765lysosomal membraneIDA
GO:0005768endosomeIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0030904retromer complexIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GeneCards VPS35
PDB 2R17
UniProt Q96QK1
MIM 601501
HGNC 13487
HPRD 06085

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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