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PRKCD protein kinase C, delta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26841 NM_006254 Homo sapiens protein kinase C, delta (PRKCD), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26841 NM_212539 Homo sapiens protein kinase C, delta (PRKCD), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu37375 XM_006713257 PREDICTED: Homo sapiens protein kinase C, delta (PRKCD), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26841 XM_006713258 PREDICTED: Homo sapiens protein kinase C, delta (PRKCD), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26841 XM_006713259 PREDICTED: Homo sapiens protein kinase C, delta (PRKCD), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26841C NM_006254 Homo sapiens protein kinase C, delta (PRKCD), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu26841C NM_212539 Homo sapiens protein kinase C, delta (PRKCD), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu37375C XM_006713257 PREDICTED: Homo sapiens protein kinase C, delta (PRKCD), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu26841C XM_006713258 PREDICTED: Homo sapiens protein kinase C, delta (PRKCD), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu26841C XM_006713259 PREDICTED: Homo sapiens protein kinase C, delta (PRKCD), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol PRKCD
Entrez Gene ID 5580
Full Name protein kinase C, delta
Synonyms CVID9, MAY1, PKCD, nPKC-delta
General protein information
Preferred Names
protein kinase C delta type
Names
protein kinase C delta type
protein kinase C delta VIII
tyrosine-protein kinase PRKCD
NP_006245.2
NP_997704.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.31

Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
Disorder

MIM: 176977

mRNA Protein Product Sequence Price Select
NM_006254, 47157323 NP_006245, 31377782 protein kinase C delta type ORF Sequence $700.00
NM_212539, 47157324 NP_997704, 47157325 protein kinase C delta type ORF Sequence $700.00
XM_006713257, 578806368 XP_006713320, 578806369 protein kinase C delta type isoform X1 ORF Sequence $700.00
XM_006713258, 578806370 XP_006713321, 578806371 protein kinase C delta type isoform X2 ORF Sequence $700.00
XM_006713259, 578806372 XP_006713322, 578806373 protein kinase C delta type isoform X3 ORF Sequence $700.00
KEGG
hsa04664Fc epsilon RI signaling pathway
hsa04530Tight junction
hsa04930Type II diabetes mellitus
hsa04912GnRH signaling pathway
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04722Neurotrophin signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04915Estrogen signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
WikiPathways
WP382MAPK signaling pathway
WP127IL-5 Signaling Pathway
WP395IL-4 signaling Pathway
WP428Wnt Signaling Pathway
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP289Myometrial Relaxation and Contraction Pathways
WP366TGF-beta Receptor Signaling Pathway
WP1584Type II diabetes mellitus
WP481Insulin Signaling
WP399Wnt Signaling Pathway and Pluripotency
WP35G Protein Signaling Pathways
WP619Type II interferon signaling (IFNG)
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP364IL-6 Signaling Pathway
WP536Calcium Regulation in the Cardiac Cell
WP2324AGE/RAGE pathway
WP2374Oncostatin M Signaling Pathway
WP2380BDNF signaling pathway
WP2012miRs in Muscle Cell Differentiation
WP2261Signaling Pathways in Glioblastoma
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
lysophospholipid_pathwayLPA receptor mediated events
il6_7pathwayIL6-mediated signaling events
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
endothelinpathwayEndothelins
igf1_pathwayIGF1 pathway
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
erbb1_downstream_pathwayErbB1 downstream signaling
ceramide_pathwayCeramide signaling pathway
txa2pathwayThromboxane A2 receptor signaling
syndecan_2_pathwaySyndecan-2-mediated signaling events
ifngpathwayIFN-gamma pathway
mapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
p53regulationpathwayp53 pathway
syndecan_4_pathwaySyndecan-4-mediated signaling events
pdgfrbpathwayPDGFR-beta signaling pathway
Reactome
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_19184GPCR downstream signaling
REACT_19333G alpha (z) signalling events
REACT_71Gene Expression
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_2202Effects of PIP2 hydrolysis
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_9470Signaling by FGFR
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_16888Signaling by PDGF
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_9053CaM pathway
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_12079PLC-gamma1 signalling
REACT_15426PLC beta mediated events
REACT_9000Calmodulin induced events
REACT_15307Ca-dependent events
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_25078Interferon gamma signaling
REACT_25218HuR stabilizes mRNA
REACT_111064DAG and IP3 signaling
REACT_111102Signal Transduction
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116125Disease
REACT_115720PLCG1 events in ERBB2 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_120736Signaling by FGFR in disease
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160158Role of phospholipids in phagocytosis
Homo sapiens (human)PRKCDNP_006245.2
Pan troglodytes (chimpanzee)PRKCDXP_003309918.2
Macaca mulatta (Rhesus monkey)LOC694656XP_001083320.1
Canis lupus familiaris (dog)PRKCDNP_001008716.1
Bos taurus (cattle)PRKCDNP_001071323.1
Mus musculus (house mouse)PrkcdNP_035233.1
Rattus norvegicus (Norway rat)PrkcdNP_579841.1
Gallus gallus (chicken)PRKCDNP_001006133.1
Danio rerio (zebrafish)prkcdaNP_999873.1
Danio rerio (zebrafish)LOC100150844XP_001919906.4
Drosophila melanogaster (fruit fly)PkcdeltaNP_511171.3
Caenorhabditis eleganstpa-1NP_499860.1
Xenopus (Silurana) tropicalis (western clawed frog)prkcdXP_002934267.1
Process
IDNameEvidence
GO:0006468protein phosphorylationIDA
GO:0006915apoptotic processIDA
GO:0006915apoptotic processTAS
GO:0006921cellular component disassembly involved in execution phase of apoptosisTAS
GO:0007049cell cycleIEA
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007202activation of phospholipase C activityTAS
GO:0007596blood coagulationTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010467gene expressionTAS
GO:0010469regulation of receptor activityTAS
GO:0016064immunoglobulin mediated immune responseIEA
GO:0016070RNA metabolic processTAS
GO:0016071mRNA metabolic processTAS
GO:0018107peptidyl-threonine phosphorylationIDA
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0023021termination of signal transductionIMP
GO:0030168platelet activationTAS
GO:0030837negative regulation of actin filament polymerizationISS
GO:0032091negative regulation of protein bindingTAS
GO:0032613interleukin-10 productionIEA
GO:0032615interleukin-12 productionIEA
GO:0032930positive regulation of superoxide anion generationIMP
GO:0034351negative regulation of glial cell apoptotic processIMP
GO:0035307positive regulation of protein dephosphorylationIMP
GO:0035556intracellular signal transductionIEA
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTAS
GO:0042100B cell proliferationIEA
GO:0042119neutrophil activationIDA
GO:0042742defense response to bacteriumISS
GO:0043407negative regulation of MAP kinase activityIMP
GO:0045087innate immune responseTAS
GO:0046627negative regulation of insulin receptor signaling pathwayISS
GO:0046627negative regulation of insulin receptor signaling pathwayTAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0050728negative regulation of inflammatory responseIC
GO:0050732negative regulation of peptidyl-tyrosine phosphorylationISS
GO:0050821protein stabilizationNAS
GO:0051490negative regulation of filopodium assemblyISS
GO:0060333interferon-gamma-mediated signaling pathwayTAS
GO:0090331negative regulation of platelet aggregationISS
GO:0090398cellular senescenceIMP
GO:1900163positive regulation of phospholipid scramblase activityIMP
GO:2000304positive regulation of ceramide biosynthetic processIMP
GO:2000753positive regulation of glucosylceramide catabolic processIMP
GO:2000755positive regulation of sphingomyelin catabolic processIMP
GO:2001022positive regulation of response to DNA damage stimulusIMP
GO:2001235positive regulation of apoptotic signaling pathwayIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIEA
GO:0005783endoplasmic reticulumIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005911cell-cell junctionIEA
GO:0016363nuclear matrixIEA
GO:0048471perinuclear region of cytoplasmIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityIDA
GO:0004697protein kinase C activityISS
GO:0004699calcium-independent protein kinase C activityTAS
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008047enzyme activator activityIDA
GO:0019899enzyme bindingIDA
GO:0019899enzyme bindingIPI
GO:0043560insulin receptor substrate bindingISS
GO:0046872metal ion bindingIEA
GeneCards PRKCD
UniProt Q05655
Vega OTTHUMG00000133659
MIM 176977
Ensembl ENSG00000163932
HGNC 9399
HPRD 01501

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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