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MAPK8 mitogen-activated protein kinase 8 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002750 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1, mRNA. ORF Sequence $334.95
Peptide Services
Antibody Services
Protein Services
NM_139046 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b1, mRNA. ORF Sequence $334.95
Peptide Services
Antibody Services
Protein Services
NM_139047 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b2, mRNA. ORF Sequence $372.36
Peptide Services
Antibody Services
Protein Services
NM_139049 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a2, mRNA. ORF Sequence $372.36
Peptide Services
Antibody Services
Protein Services


Gene Symbol MAPK8
Entrez Gene ID 5599
Full Name mitogen-activated protein kinase 8
Synonyms JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q11.22

Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601158

mRNA Protein Product Sequence Price Select
NM_002750, 20986493 NP_002741, 4506095 mitogen-activated protein kinase 8 isoform alpha1 Full Length $410.93
ORF Sequence $334.95
NM_139046, 20986518 NP_620634, 20986519 mitogen-activated protein kinase 8 isoform beta1 Full Length $410.93
ORF Sequence $334.95
NM_139047, 20986520 NP_620635, 20986521 mitogen-activated protein kinase 8 isoform beta2 Full Length $409.48
ORF Sequence $372.36
NM_139049, 20986522 NP_620637, 20986523 mitogen-activated protein kinase 8 isoform alpha2 Full Length $409.48
ORF Sequence $372.36
KEGG
hsa04620Toll-like receptor signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa04930Type II diabetes mellitus
hsa05161Hepatitis B
hsa05160Hepatitis C
hsa04012ErbB signaling pathway
hsa05133Pertussis
hsa04912GnRH signaling pathway
hsa05164Influenza A
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04728Dopaminergic synapse
hsa05212Pancreatic cancer
hsa04722Neurotrophin signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05169Epstein-Barr virus infection
hsa04621NOD-like receptor signaling pathway
hsa04510Focal adhesion
hsa04622RIG-I-like receptor signaling pathway
hsa05166HTLV-I infection
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa05131Shigellosis
hsa04910Insulin signaling pathway
hsa04380Osteoclast differentiation
hsa05210Colorectal cancer
hsa05145Toxoplasmosis
hsa04310Wnt signaling pathway
hsa05152Tuberculosis
hsa05132Salmonella infection
hsa04723Retrograde endocannabinoid signaling
hsa04914Progesterone-mediated oocyte maturation
hsa05168Herpes simplex infection
hsa05142Chagas disease (American trypanosomiasis)
Pathway Interaction Database
foxopathwayFoxO family signaling
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
p53regulationpathwayp53 pathway
rac1_pathwayRAC1 signaling pathway
p75ntrpathwayp75(NTR)-mediated signaling
il12_stat4pathwayIL12 signaling mediated by STAT4
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
fcer1pathwayFc-epsilon receptor I signaling in mast cells
il2_1pathwayIL2-mediated signaling events
ncadherinpathwayN-cadherin signaling events
ephrinbrevpathwayEphrin B reverse signaling
endothelinpathwayEndothelins
avb3_opn_pathwayOsteopontin-mediated events
erbb1_downstream_pathwayErbB1 downstream signaling
s1p_s1p2_pathwayS1P2 pathway
fak_pathwaySignaling events mediated by focal adhesion kinase
tcrjnkpathwayJNK signaling in the CD4+ TCR pathway
cd40_pathwayCD40/CD40L signaling
erbb2erbb3pathwayErbB2/ErbB3 signaling events
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
wnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
reg_gr_pathwayGlucocorticoid receptor regulatory network
ar_tf_pathwayRegulation of Androgen receptor activity
epopathwayEPO signaling pathway
il1pathwayIL1-mediated signaling events
bcr_5pathwayBCR signaling pathway
cdc42_pathwayCDC42 signaling events
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
glypican_3pathwayGlypican 3 network
ceramide_pathwayCeramide signaling pathway
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
rapid_gr_pathwayRapid glucocorticoid signaling
reelinpathwayReelin signaling pathway
retinoic_acid_pathwayRetinoic acid receptors-mediated signaling
trail_pathwayTRAIL signaling pathway
nephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
faspathwayFAS (CD95) signaling pathway
ret_pathwaySignaling events regulated by Ret tyrosine kinase
syndecan_2_pathwaySyndecan-2-mediated signaling events
hivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
atf2_pathwayATF-2 transcription factor network
rhoa_pathwayRhoA signaling pathway
WikiPathways
WP673ErbB signaling pathway
WP2034Leptin signaling pathway
WP363Wnt Signaling Pathway NetPath
WP710DNA damage response (only ATM dependent)
WP3Keap1-Nrf2 Pathway
WP2203TSLP Signaling Pathway
WP1584Type II diabetes mellitus
WP2374Oncostatin M Signaling Pathway
WP314FAS pathway and Stress induction of HSP regulation
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP313Signaling of Hepatocyte Growth Factor Receptor
WP437EGFR1 Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
WP2018RANKL/RANK Signaling Pathway
WP288NLR proteins
WP23B Cell Receptor Signaling Pathway
WP2324AGE/RAGE pathway
WP75Toll-like receptor signaling pathway
WP69TCR Signaling Pathway
WP49IL-2 Signaling Pathway
WP2037Prolactin Signaling Pathway
WP364IL-6 Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP1772Apoptosis Modulation and Signaling
WP382MAPK signaling pathway
WP286IL-3 Signaling Pathway
WP481Insulin Signaling
WP2256Integrated Pancreatic Cancer Pathway
WP306Focal Adhesion
WP262EBV LMP1 signaling
WP2036TWEAK Signaling Pathway
Reactome
REACT_13638NRAGE signals death through JNK
REACT_6802Innate Immune System
REACT_11061Signalling by NGF
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_13776p75 NTR receptor-mediated signalling
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_6809MyD88-independent cascade
REACT_1650Activation of BIM and translocation to mitochondria
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_21308MAP kinase activation in TLR cascade
REACT_697Activation of BH3-only proteins
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_111155Cell-Cell communication
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_111102Signal Transduction
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_25299DSCAM interactions
REACT_6966Toll Receptor Cascades
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_964Intrinsic Pathway for Apoptosis
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_2100Activation of BMF and translocation to mitochondria
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_578Apoptosis
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_6900Immune System
REACT_13643NRIF signals cell death from the nucleus
REACT_6890Activated TLR4 signalling
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_21326Activation of the AP-1 family of transcription factors
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
Homo sapiens (human)MAPK8NP_620637.1
Pan troglodytes (chimpanzee)MAPK8XP_001136927.1
Macaca mulatta (Rhesus monkey)MAPK8XP_001108815.1
Canis lupus familiaris (dog)MAPK8XP_534943.2
Bos taurus (cattle)MAPK8NP_001179903.1
Mus musculus (house mouse)Mapk8NP_057909.1
Rattus norvegicus (Norway rat)Mapk8XP_341400.4
Gallus gallus (chicken)MAPK8XP_001233169.1
Danio rerio (zebrafish)mapk8aNP_001103859.1
Drosophila melanogaster (fruit fly)bskNP_001162930.1
Caenorhabditis elegansjnk-1NP_001021270.1
GeneCards MAPK8
PDB 1UKH, 2GMX, 1UKI, 2XS0, 2XRW, 3O2M, 3VUK, 3VUD, 3ELJ, 3VUI, 3V3V, 3PZE, 3VUM, 3VUL, 2G01, 3VUG, 2H96, 3VUH, 3O17, 2NO3
UniProt A1L4K2, P45983
MIM 601158
Ensembl ENSG00000107643
HGNC 6881
HPRD 03100

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
mitogen-activated protein kinase 8
Names
mitogen-activated protein kinase 8
MAP kinase 8
JUN N-terminal kinase
c-Jun N-terminal kinase 1
stress-activated protein kinase 1
stress-activated protein kinase 1c
mitogen-activated protein kinase 8 isoform JNK1 beta2
mitogen-activated protein kinase 8 isoform JNK1 alpha1
NP_002741.1
NP_620634.1
NP_620635.1
NP_620637.1

Interactant

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