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MAPK8 mitogen-activated protein kinase 8 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001278547 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001278548 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_002750 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_139046 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_139049 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006717917 PREDICTED: Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006717918 PREDICTED: Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006717919 PREDICTED: Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

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Gene Symbol MAPK8
Entrez Gene ID 5599
Full Name mitogen-activated protein kinase 8
Synonyms JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
General protein information
Preferred Names
mitogen-activated protein kinase 8
mitogen-activated protein kinase 8
MAP kinase 8
JUN N-terminal kinase
c-Jun N-terminal kinase 1
stress-activated protein kinase 1
stress-activated protein kinase 1c
mitogen-activated protein kinase 8 isoform JNK1 beta2
mitogen-activated protein kinase 8 isoform JNK1 alpha1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013].

MIM: 601158

mRNA Protein Product Sequence Price Select
NM_001278547, 513788278 NP_001265476, 513788279 mitogen-activated protein kinase 8 JNK1 beta2 ORF Sequence $550.00
NM_001278548, 513788280 NP_001265477, 513788281 mitogen-activated protein kinase 8 isoform 5 ORF Sequence $300.00
NM_002750, 513788275 NP_002741, 4506095 mitogen-activated protein kinase 8 isoform alpha1 ORF Sequence $269.00
NM_139046, 513788276 NP_620634, 20986519 mitogen-activated protein kinase 8 isoform beta1 ORF Sequence $400.00
NM_139049, 513788277 NP_620637, 20986523 mitogen-activated protein kinase 8 isoform alpha2 ORF Sequence $550.00
XM_006717917, 578819632 XP_006717980, 578819633 mitogen-activated protein kinase 8 isoform X1 ORF Sequence $550.00
XM_006717918, 578819634 XP_006717981, 578819635 mitogen-activated protein kinase 8 isoform X2 ORF Sequence $400.00
XM_006717919, 578819636 XP_006717982, 578819637 mitogen-activated protein kinase 8 isoform X3 ORF Sequence $400.00
hsa04012ErbB signaling pathway
hsa04310Wnt signaling pathway
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
hsa04664Fc epsilon RI signaling pathway
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa04620Toll-like receptor signaling pathway
hsa04912GnRH signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05212Pancreatic cancer
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa04722Neurotrophin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04622RIG-I-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04141Protein processing in endoplasmic reticulum
hsa05160Hepatitis C
hsa05166HTLV-I infection
hsa04380Osteoclast differentiation
hsa05164Influenza A
hsa05132Salmonella infection
hsa05168Herpes simplex infection
hsa04728Dopaminergic synapse
hsa05161Hepatitis B
hsa04723Retrograde endocannabinoid signaling
hsa05169Epstein-Barr virus infection
hsa04668TNF signaling pathway
hsa04917Prolactin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04750Inflammatory mediator regulation of TRP channels
hsa04014Ras signaling pathway
hsa04068FoxO signaling pathway
WP382MAPK signaling pathway
WP437EGFR1 Signaling Pathway
WP3Keap1-Nrf2 Pathway
WP12Osteoclast Signaling
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP366TGF-beta Receptor Signaling Pathway
WP288NLR proteins
WP1584Type II diabetes mellitus
WP363Wnt Signaling Pathway NetPath
WP262EBV LMP1 signaling
WP1772Apoptosis Modulation and Signaling
WP481Insulin Signaling
WP286IL-3 Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP673ErbB signaling pathway
WP75Toll-like receptor signaling pathway
WP69TCR Signaling Pathway
WP314FAS pathway and Stress induction of HSP regulation
WP23B Cell Receptor Signaling Pathway
WP364IL-6 Signaling Pathway
WP2324AGE/RAGE pathway
WP2374Oncostatin M Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2380BDNF signaling pathway
WP2036TWEAK Signaling Pathway
WP2034Leptin signaling pathway
WP2037Prolactin Signaling Pathway
WP2018RANKL/RANK Signaling Pathway
WP2203TSLP Signaling Pathway
WP2263Prostate Cancer
WP1528Physiological and Pathological Hypertrophy of the Heart
WP1449Regulation of toll-like receptor signaling pathway
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
rapid_gr_pathwayRapid glucocorticoid signaling
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
il12_stat4pathwayIL12 signaling mediated by STAT4
hivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
il2_1pathwayIL2-mediated signaling events
erbb2erbb3pathwayErbB2/ErbB3 signaling events
reelinpathwayReelin signaling pathway
ret_pathwaySignaling events regulated by Ret tyrosine kinase
trail_pathwayTRAIL signaling pathway
avb3_opn_pathwayOsteopontin-mediated events
cdc42_pathwayCDC42 signaling events
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
foxopathwayFoxO family signaling
ncadherinpathwayN-cadherin signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
retinoic_acid_pathwayRetinoic acid receptors-mediated signaling
erbb1_downstream_pathwayErbB1 downstream signaling
faspathwayFAS (CD95) signaling pathway
ceramide_pathwayCeramide signaling pathway
bcr_5pathwayBCR signaling pathway
atf2_pathwayATF-2 transcription factor network
syndecan_2_pathwaySyndecan-2-mediated signaling events
nephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
ar_tf_pathwayRegulation of Androgen receptor activity
s1p_s1p2_pathwayS1P2 pathway
cd40_pathwayCD40/CD40L signaling
fcer1pathwayFc-epsilon receptor I signaling in mast cells
p53regulationpathwayp53 pathway
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
p75ntrpathwayp75(NTR)-mediated signaling
epopathwayEPO signaling pathway
ephrinbrevpathwayEphrin B reverse signaling
tcrjnkpathwayJNK signaling in the CD4+ TCR pathway
glypican_3pathwayGlypican 3 network
rhoa_pathwayRhoA signaling pathway
fak_pathwaySignaling events mediated by focal adhesion kinase
rac1_pathwayRAC1 signaling pathway
wnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
REACT_964Intrinsic Pathway for Apoptosis
REACT_2100Activation of BMF and translocation to mitochondria
REACT_697Activation of BH3-only proteins
REACT_1650Activation of BIM and translocation to mitochondria
REACT_6966Toll-Like Receptors Cascades
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6809MyD88-independent cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_13638NRAGE signals death through JNK
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_13643NRIF signals cell death from the nucleus
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_21308MAP kinase activation in TLR cascade
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_21326Activation of the AP-1 family of transcription factors
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_25299DSCAM interactions
REACT_111102Signal Transduction
REACT_111155Cell-Cell communication
REACT_120956Cellular responses to stress
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_169274Cellular Senescence
REACT_169436Oxidative Stress Induced Senescence
Homo sapiens (human)MAPK8NP_001265476.1
Pan troglodytes (chimpanzee)MAPK8XP_001136927.1
Macaca mulatta (Rhesus monkey)MAPK8XP_001108815.1
Canis lupus familiaris (dog)MAPK8XP_005637524.1
Bos taurus (cattle)MAPK8NP_001179903.1
Mus musculus (house mouse)Mapk8NP_057909.1
Rattus norvegicus (Norway rat)Mapk8NP_446281.1
Gallus gallus (chicken)MAPK8XP_001233169.1
Danio rerio (zebrafish)mapk8aNP_001103859.1
Drosophila melanogaster (fruit fly)bskNP_001162930.1
Caenorhabditis elegansjnk-1NP_001021270.1
Xenopus (Silurana) tropicalis (western clawed frog)mapk8NP_001123415.1
GO:0002224toll-like receptor signaling pathwayTAS
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTAS
GO:0002756MyD88-independent toll-like receptor signaling pathwayTAS
GO:0006915apoptotic processTAS
GO:0006950response to stressTAS
GO:0007254JNK cascadeIDA
GO:0007254JNK cascadeTAS
GO:0007258JUN phosphorylationIDA
GO:0009411response to UVIDA
GO:0010628positive regulation of gene expressionIMP
GO:0018105peptidyl-serine phosphorylationIDA
GO:0018107peptidyl-threonine phosphorylationIDA
GO:0018107peptidyl-threonine phosphorylationIMP
GO:0031063regulation of histone deacetylationIMP
GO:0032091negative regulation of protein bindingIDA
GO:0032880regulation of protein localizationIDA
GO:0034134toll-like receptor 2 signaling pathwayTAS
GO:0034138toll-like receptor 3 signaling pathwayTAS
GO:0034142toll-like receptor 4 signaling pathwayTAS
GO:0034146toll-like receptor 5 signaling pathwayTAS
GO:0034162toll-like receptor 9 signaling pathwayTAS
GO:0034166toll-like receptor 10 signaling pathwayTAS
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTAS
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0038123toll-like receptor TLR1:TLR2 signaling pathwayTAS
GO:0038124toll-like receptor TLR6:TLR2 signaling pathwayTAS
GO:0043065positive regulation of apoptotic processTAS
GO:0043066negative regulation of apoptotic processIDA
GO:0045087innate immune responseTAS
GO:0046686response to cadmium ionIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0051090regulation of sequence-specific DNA binding transcription factor activityTAS
GO:0051403stress-activated MAPK cascadeTAS
GO:0071222cellular response to lipopolysaccharideIDA
GO:0071260cellular response to mechanical stimulusIEP
GO:0090045positive regulation of deacetylase activityIMP
GO:0097190apoptotic signaling pathwayTAS
GO:0097193intrinsic apoptotic signaling pathwayTAS
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS
GO:2000017positive regulation of determination of dorsal identityIEA
GO:2001235positive regulation of apoptotic signaling pathwayIEA
GO:0004674protein serine/threonine kinase activityIDA
GO:0004705JUN kinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0035033histone deacetylase regulator activityIMP
GO:0042826histone deacetylase bindingIPI
GeneCards MAPK8
UniProt A1L4K2, P45983
Vega OTTHUMG00000018172
MIM 601158
Ensembl ENSG00000107643
HGNC 6881
HPRD 03100

GeneRIFs: Gene References Into Functions What's a GeneRIF?


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