MAPK8 mitogen-activated protein kinase 8 [Homo sapiens (human)]

RefSeq Accession	Definition	Sequence	Price	Select
NM_002750	Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1, mRNA.	Full Length	$410.93
NM_002750		ORF Sequence	$334.95
NM_139046	Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b1, mRNA.	Full Length	$410.93
NM_139046		ORF Sequence	$334.95
NM_139047	Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b2, mRNA.	Full Length	$409.48
NM_139047		ORF Sequence	$372.36
NM_139049	Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a2, mRNA.	Full Length	$409.48
NM_139049		ORF Sequence	$372.36

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	MAPK8
Entrez Gene ID	5599
Full Name	mitogen-activated protein kinase 8
Synonyms	JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:10 Map Location:10q11.22
Summary	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Disorder	MIM: 601158

mRNA	NM_002750, 20986493
Protein	NP_002741, 4506095
Product	mitogen-activated protein kinase 8 isoform JNK1 alpha1
RefSeq Status	REVIEWED
mRNA	NM_139046, 20986518
Protein	NP_620634, 20986519
Product	mitogen-activated protein kinase 8 isoform JNK1 beta1
RefSeq Status	REVIEWED
mRNA	NM_139047, 20986520
Protein	NP_620635, 20986521
Product	mitogen-activated protein kinase 8 isoform JNK1 beta2
RefSeq Status	REVIEWED
mRNA	NM_139049, 20986522
Protein	NP_620637, 20986523
Product	mitogen-activated protein kinase 8 isoform JNK1 alpha2
RefSeq Status	REVIEWED

KEGG

hsa04012	ErbB signaling pathway
hsa04912	GnRH signaling pathway
hsa05212	Pancreatic cancer
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa05200	Pathways in cancer
hsa04010	MAPK signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04510	Focal adhesion
hsa04910	Insulin signaling pathway
hsa05131	Shigellosis
hsa04380	Osteoclast differentiation
hsa05210	Colorectal cancer
hsa05145	Toxoplasmosis
hsa04310	Wnt signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa05142	Chagas disease (American trypanosomiasis)
hsa04620	Toll-like receptor signaling pathway
hsa04141	Protein processing in endoplasmic reticulum
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa04930	Type II diabetes mellitus
hsa05160	Hepatitis C

WikiPathways

WP3	Keap1-Nrf2 Pathway
WP75	Toll-like receptor signaling pathway
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP366	TGF-beta Receptor Signaling Pathway
WP23	B Cell Receptor Signaling Pathway
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP288	NLR proteins
WP364	IL-6 Signaling Pathway
WP49	IL-2 Signaling Pathway
WP382	MAPK signaling pathway
WP286	IL-3 Signaling Pathway
WP481	Insulin Signaling
WP306	Focal Adhesion
WP314	FAS pathway and Stress induction of HSP regulation
WP673	ErbB signaling pathway
WP363	Wnt Signaling Pathway NetPath
WP437	EGFR1 Signaling Pathway

Pathway Interaction Database

reg_gr_pathway	Glucocorticoid receptor regulatory network
fcer1pathway	Fc-epsilon receptor I signaling in mast cells
p75ntrpathway	p75(NTR)-mediated signaling
il2_1pathway	IL2-mediated signaling events
il12_stat4pathway	IL12 signaling mediated by STAT4
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
s1p_s1p2_pathway	S1P2 pathway
ncadherinpathway	N-cadherin signaling events
ephrinbrevpathway	Ephrin B reverse signaling
cd40_pathway	CD40/CD40L signaling
tcrjnkpathway	JNK signaling in the CD4+ TCR pathway
ceramide_pathway	Ceramide signaling pathway
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
reelinpathway	Reelin signaling pathway
bcr_5pathway	BCR signaling pathway
il1pathway	IL1-mediated signaling events
cdc42_pathway	CDC42 signaling events
met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
wnt_noncanonical_pathway	Noncanonical Wnt signaling pathway
ar_tf_pathway	Regulation of Androgen receptor activity
rapid_gr_pathway	Rapid glucocorticoid signaling
retinoic_acid_pathway	Retinoic acid receptors-mediated signaling
epopathway	EPO signaling pathway
cd8tcrdownstreampathway	Downstream signaling in naive CD8+ T cells
glypican_3pathway	Glypican 3 network
nephrin_neph1_pathway	Nephrin/Neph1 signaling in the kidney podocyte
trail_pathway	TRAIL signaling pathway
faspathway	FAS (CD95) signaling pathway
ret_pathway	Signaling events regulated by Ret tyrosine kinase
syndecan_2_pathway	Syndecan-2-mediated signaling events
hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha
atf2_pathway	ATF-2 transcription factor network
rhoa_pathway	RhoA signaling pathway
endothelinpathway	Endothelins
avb3_opn_pathway	Osteopontin-mediated events
foxopathway	FoxO family signaling
p53regulationpathway	p53 pathway
nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes
erbb2erbb3pathway	ErbB2/ErbB3 signaling events
fak_pathway	Signaling events mediated by focal adhesion kinase
rac1_pathway	RAC1 signaling pathway
erbb1_downstream_pathway	ErbB1 downstream signaling

Reactome

REACT_9020	Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_1650	Activation of BIM and translocation to mitochondria
REACT_23853	Interactions of the immunoglobulin superfamily (IgSF) member proteins
REACT_21368	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_6966	Toll Receptor Cascades
REACT_6894	Toll Like Receptor 4 (TLR4) Cascade
REACT_25299	DSCAM interactions
REACT_25281	NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
REACT_25024	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_6788	MyD88:Mal cascade initiated on plasma membrane
REACT_964	Intrinsic Pathway for Apoptosis
REACT_9047	Toll Like Receptor 9 (TLR9) Cascade
REACT_2100	Activation of BMF and translocation to mitochondria
REACT_25222	MyD88 dependent cascade initiated on endosome
REACT_578	Apoptosis
REACT_6900	Signaling in Immune system
REACT_13720	Cell death signalling via NRAGE, NRIF and NADE
REACT_6782	TRAF6 Mediated Induction of proinflammatory cytokines
REACT_13643	NRIF signals cell death from the nucleus
REACT_6890	Activated TLR4 signalling
REACT_7980	Toll Like Receptor 2 Cascade
REACT_21326	Activation of the AP-1 family of transcription factors
REACT_8006	Toll Like Receptor TLR6:TLR2 Cascade
REACT_13638	NRAGE signals death through JNK
REACT_21308	MAP kinase activation in TLR cascade
REACT_6802	Innate Immunity Signaling
REACT_697	Activation of BH3-only proteins
REACT_6809	MyD88-independent cascade initiated on plasma membrane
REACT_11061	Signalling by NGF
REACT_21328	MAPK targets/ Nuclear events mediated by MAP kinases
REACT_13776	p75 NTR receptor-mediated signalling
REACT_6783	Toll Like Receptor 3 (TLR3) Cascade
REACT_8005	Toll Like Receptor TLR1:TLR2 Cascade

Homo sapiens (human)	MAPK8	NP_620637.1
Pan troglodytes (chimpanzee)	MAPK8	XP_507778.2
Canis lupus familiaris (dog)	MAPK8	XP_534943.2
Bos taurus (cattle)	MAPK8	XP_869760.1
Mus musculus (house mouse)	Mapk8	NP_057909.1
Rattus norvegicus (Norway rat)	Mapk8	XP_341400.3
Gallus gallus (chicken)	MAPK8	XP_421650.2
Danio rerio (zebrafish)	zgc:172209	NP_001103859.1
Danio rerio (zebrafish)	LOC100333971	XP_002663918.1
Danio rerio (zebrafish)	mapk8	NP_571796.1

Process

ID	Name	Evidence
GO:0001503	ossification	IEA
GO:0002224	toll-like receptor signaling pathway	TAS
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	EXP
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0002756	MyD88-independent toll-like receptor signaling pathway	EXP
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS
GO:0006915	apoptosis	EXP
GO:0006915	apoptosis	TAS
GO:0006950	response to stress	TAS
GO:0007254	JNK cascade	IDA
GO:0007254	JNK cascade	TAS
GO:0007258	JUN phosphorylation	IDA
GO:0007258	JUN phosphorylation	TAS
GO:0008063	Toll signaling pathway	TAS
GO:0008624	induction of apoptosis by extracellular signals	EXP
GO:0008629	induction of apoptosis by intracellular signals	TAS
GO:0008633	activation of pro-apoptotic gene products	EXP
GO:0008633	activation of pro-apoptotic gene products	TAS
GO:0009411	response to UV	IDA
GO:0016310	phosphorylation	EXP
GO:0018105	peptidyl-serine phosphorylation	IDA
GO:0018107	peptidyl-threonine phosphorylation	IDA
GO:0018107	peptidyl-threonine phosphorylation	IMP
GO:0031063	regulation of histone deacetylation	IMP
GO:0031558	induction of apoptosis in response to chemical stimulus	IEA
GO:0032091	negative regulation of protein binding	IDA
GO:0032880	regulation of protein localization	IDA
GO:0034130	toll-like receptor 1 signaling pathway	TAS
GO:0034134	toll-like receptor 2 signaling pathway	TAS
GO:0034138	toll-like receptor 3 signaling pathway	TAS
GO:0034142	toll-like receptor 4 signaling pathway	TAS
GO:0043066	negative regulation of apoptosis	IDA
GO:0045087	innate immune response	TAS
GO:0046686	response to cadmium ion	IEA
GO:0048011	nerve growth factor receptor signaling pathway	TAS
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	TAS
GO:0051403	stress-activated MAPK cascade	TAS
GO:0071260	cellular response to mechanical stimulus	IEP
GO:0090045	positive regulation of deacetylase activity	IMP
GO:2000017	positive regulation of determination of dorsal identity	IEA

Component

ID	Name	Evidence
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	EXP
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IEA
GO:0005829	cytosol	EXP
GO:0005829	cytosol	TAS

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0004674	protein serine/threonine kinase activity	EXP
GO:0004674	protein serine/threonine kinase activity	IDA
GO:0004705	JUN kinase activity	IDA
GO:0004705	JUN kinase activity	TAS
GO:0004707	MAP kinase activity	IEA
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0016301	kinase activity	EXP
GO:0035033	histone deacetylase regulator activity	IMP
GO:0042826	histone deacetylase binding	IPI

GeneCards	MAPK8
PDB	1UKH, 2GMX, 1UKI, 3O2M, 2G01, 2H96, 3ELJ, 3O17, 2NO3
UniProt	A1L4K2, P45983
MIM	601158
Ensembl	ENSG00000107643
HGNC	6881
HPRD	03100

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