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MAP2K1 mitogen-activated protein kinase kinase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002755 Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_005254541 PREDICTED: Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006720608 PREDICTED: Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol MAP2K1
Entrez Gene ID 5604
Full Name mitogen-activated protein kinase kinase 1
Synonyms CFC3, MAPKK1, MEK1, MKK1, PRKMK1
General protein information
Preferred Names
dual specificity mitogen-activated protein kinase kinase 1
Names
dual specificity mitogen-activated protein kinase kinase 1
MEK 1
MAPKK 1
MAPK/ERK kinase 1
ERK activator kinase 1
protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
NP_002746.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22.1-q22.33

Summary The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].
Disorder

MIM: 176872

Cardiofaciocutaneous syndrome, 115150 (3)

mRNA Protein Product Sequence Price Select
NM_002755, 169790828 NP_002746, 5579478 dual specificity mitogen-activated protein kinase kinase 1 ORF Sequence $269.00
XM_005254541, 530406179 XP_005254598, 530406180 dual specificity mitogen-activated protein kinase kinase 1 isoform X2 ORF Sequence $300.00
XM_006720608, 578827194 XP_006720671, 578827195 dual specificity mitogen-activated protein kinase kinase 1 isoform X3 ORF Sequence $400.00
KEGG
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04510Focal adhesion
hsa04664Fc epsilon RI signaling pathway
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04370VEGF signaling pathway
hsa04662B cell receptor signaling pathway
hsa04910Insulin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04916Melanogenesis
hsa04660T cell receptor signaling pathway
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa04620Toll-like receptor signaling pathway
hsa04912GnRH signaling pathway
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05221Acute myeloid leukemia
hsa05219Bladder cancer
hsa05200Pathways in cancer
hsa04540Gap junction
hsa05210Colorectal cancer
hsa05216Thyroid cancer
hsa05220Chronic myeloid leukemia
hsa05223Non-small cell lung cancer
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa05020Prion diseases
hsa04722Neurotrophin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04666Fc gamma R-mediated phagocytosis
hsa04320Dorso-ventral axis formation
hsa04114Oocyte meiosis
hsa04380Osteoclast differentiation
hsa05164Influenza A
hsa04725Cholinergic synapse
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04066HIF-1 signaling pathway
hsa04726Serotonergic synapse
hsa05205Proteoglycans in cancer
hsa04915Estrogen signaling pathway
hsa05034Alcoholism
hsa05206MicroRNAs in cancer
hsa04668TNF signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP382MAPK signaling pathway
WP437EGFR1 Signaling Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP1434Osteopontin Signaling
WP615Senescence and Autophagy
WP666Hypothetical Network for Drug Addiction
WP304Kit Receptor Signaling Pathway
WP712Estrogen signaling pathway
WP734Serotonin Receptor 4/6/7 and NR3C Signaling
WP481Insulin Signaling
WP286IL-3 Signaling Pathway
WP673ErbB signaling pathway
WP205IL-7 Signaling Pathway
WP185Integrin-mediated cell adhesion
WP422MAPK Cascade
WP22IL-9 Signaling Pathway
WP732Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP49IL-2 Signaling pathway
WP75Toll-like receptor signaling pathway
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP51Regulation of Actin Cytoskeleton
WP364IL-6 Signaling Pathway
WP581EPO Receptor Signaling
WP259Nifedipine Activity
WP2324AGE/RAGE pathway
WP2374Oncostatin M Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2380BDNF signaling pathway
WP2034Leptin signaling pathway
WP2032TSH signaling pathway
WP2197Endothelin
WP2261Signaling Pathways in Glioblastoma
WP2037Prolactin Signaling Pathway
WP2018RANKL/RANK Signaling Pathway
WP2203TSLP Signaling Pathway
WP2263Prostate Cancer
WP1449Regulation of toll-like receptor signaling pathway
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
tcrraspathwayRas signaling in the CD4+ TCR pathway
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
foxm1pathwayFOXM1 transcription factor network
il2_1pathwayIL2-mediated signaling events
erbb2erbb3pathwayErbB2/ErbB3 signaling events
endothelinpathwayEndothelins
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
erbb1_downstream_pathwayErbB1 downstream signaling
ephbfwdpathwayEPHB forward signaling
ceramide_pathwayCeramide signaling pathway
ar_nongenomic_pathwayNongenotropic Androgen signaling
cxcr3pathwayCXCR3-mediated signaling events
bcr_5pathwayBCR signaling pathway
ifngpathwayIFN-gamma pathway
mapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
anthraxpathwayCellular roles of Anthrax toxin
fcer1pathwayFc-epsilon receptor I signaling in mast cells
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pi3kcibpathwayClass IB PI3K non-lipid kinase events
mtor_4pathwaymTOR signaling pathway
fak_pathwaySignaling events mediated by focal adhesion kinase
BIOCYC
HUMAN_PWY66-14MAP kinase cascade
Reactome
REACT_634RAF/MAP kinase cascade
REACT_614RAF phosphorylates MEK
REACT_18266Axon guidance
REACT_1391ERK1 activation
REACT_962MEK activation
REACT_18334NCAM signaling for neurite out-growth
REACT_1482ERK activation
REACT_9470Signaling by FGFR
REACT_12579SHC1 events in EGFR signaling
REACT_12606GRB2 events in EGFR signaling
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_16888Signaling by PDGF
REACT_6966Toll-Like Receptors Cascades
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6809MyD88-independent cascade
REACT_17025Downstream signal transduction
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_762IRS-related events
REACT_1195Insulin receptor signalling cascade
REACT_999SHC-related events
REACT_661SHC-mediated signalling
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_524SOS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12033Signalling to RAS
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12076Frs2-mediated activation
REACT_12002ARMS-mediated activation
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_12077Signalling to p38 via RIT and RIN
REACT_12005Prolonged ERK activation events
REACT_21308MAP kinase activation in TLR cascade
REACT_22232Signaling by Interleukins
REACT_21272Downstream signaling of activated FGFR
REACT_22442Interleukin-1 signaling
REACT_21247FRS2-mediated cascade
REACT_22205L1CAM interactions
REACT_22272Signal transduction by L1
REACT_27283Interleukin-2 signaling
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_75790Cytokine Signaling in Immune system
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_111045Developmental Biology
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_115854GRB2 events in ERBB2 signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_116005SHC1 events in ERBB4 signaling
REACT_120736Signaling by FGFR in disease
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150139SHC-related events triggered by IGF1R
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
REACT_169118Signaling by Leptin
Homo sapiens (human)MAP2K1NP_002746.1
Pan troglodytes (chimpanzee)MAP2K1NP_001009071.1
Macaca mulatta (Rhesus monkey)MAP2K1XP_001110225.1
Canis lupus familiaris (dog)MAP2K1NP_001041559.1
Bos taurus (cattle)MAP2K1NP_001124224.1
Mus musculus (house mouse)Map2k1NP_032953.1
Rattus norvegicus (Norway rat)Map2k1NP_113831.1
Gallus gallus (chicken)MAP2K1NP_001005830.1
Danio rerio (zebrafish)map2k1NP_998584.2
Drosophila melanogaster (fruit fly)Dsor1NP_511098.1
Caenorhabditis elegansmek-2NP_491087.1
Arabidopsis thaliana (thale cress)MEK1NP_974619.1
Arabidopsis thaliana (thale cress)MKK2NP_194710.1
Xenopus (Silurana) tropicalis (western clawed frog)map2k1NP_001008058.1
Process
IDNameEvidence
GO:0000165MAPK cascadeTAS
GO:0000186activation of MAPKK activityTAS
GO:0000187activation of MAPK activityTAS
GO:0002224toll-like receptor signaling pathwayTAS
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTAS
GO:0002756MyD88-independent toll-like receptor signaling pathwayTAS
GO:0003056regulation of vascular smooth muscle contractionIEA
GO:0006928cellular component movementTAS
GO:0006935chemotaxisTAS
GO:0006979response to oxidative stressIEA
GO:0007050cell cycle arrestIMP
GO:0007067mitotic nuclear divisionIEA
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007264small GTPase mediated signal transductionTAS
GO:0007265Ras protein signal transductionTAS
GO:0007411axon guidanceTAS
GO:0008283cell proliferationIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010628positive regulation of gene expressionIMP
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0030216keratinocyte differentiationIEA
GO:0030335positive regulation of cell migrationIEA
GO:0032320positive regulation of Ras GTPase activityIEA
GO:0032402melanosome transportIEA
GO:0032872regulation of stress-activated MAPK cascadeTAS
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoterIEA
GO:0034111negative regulation of homotypic cell-cell adhesionIEA
GO:0034134toll-like receptor 2 signaling pathwayTAS
GO:0034138toll-like receptor 3 signaling pathwayTAS
GO:0034142toll-like receptor 4 signaling pathwayTAS
GO:0034146toll-like receptor 5 signaling pathwayTAS
GO:0034162toll-like receptor 9 signaling pathwayTAS
GO:0034166toll-like receptor 10 signaling pathwayTAS
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTAS
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0038123toll-like receptor TLR1:TLR2 signaling pathwayTAS
GO:0038124toll-like receptor TLR6:TLR2 signaling pathwayTAS
GO:0045087innate immune responseTAS
GO:0045597positive regulation of cell differentiationIEA
GO:0046579positive regulation of Ras protein signal transductionIEA
GO:0047496vesicle transport along microtubuleIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048313Golgi inheritanceIEA
GO:0048678response to axon injuryIEA
GO:0048870cell motilityIEA
GO:0051291protein heterooligomerizationIEA
GO:0051384response to glucocorticoidIEA
GO:0051403stress-activated MAPK cascadeTAS
GO:0060674placenta blood vessel developmentIEA
GO:0060711labyrinthine layer developmentIEA
GO:0071902positive regulation of protein serine/threonine kinase activityIDA
GO:0090170regulation of Golgi inheritanceTAS
GO:0090398cellular senescenceIMP
GO:2000641regulation of early endosome to late endosome transportTAS
Component
IDNameEvidence
GO:0005634nucleusTAS
GO:0005737cytoplasmIDA
GO:0005739mitochondrionTAS
GO:0005769early endosomeTAS
GO:0005770late endosomeTAS
GO:0005794Golgi apparatusTAS
GO:0005815microtubule organizing centerIEA
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0005925focal adhesionTAS
GO:0005938cell cortexIEA
GO:0032839dendrite cytoplasmIEA
GO:0043204perikaryonIEA
GO:0048471perinuclear region of cytoplasmIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004672protein kinase activityTAS
GO:0004674protein serine/threonine kinase activityTAS
GO:0004708MAP kinase kinase activityIDA
GO:0004712protein serine/threonine/tyrosine kinase activityTAS
GO:0004713protein tyrosine kinase activityIEA
GO:0004728receptor signaling protein tyrosine phosphatase activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0017016Ras GTPase bindingIEA
GO:0031435mitogen-activated protein kinase kinase kinase bindingIEA
GO:0043539protein serine/threonine kinase activator activityIDA
GeneCards MAP2K1
UniProt Q02750, A4QPA9
MIM 176872
HGNC 6840
HPRD 01469

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MAP2K1 gene?

The MAP2K1 gene provides instructions for making a protein known as MEK1 protein kinase. This protein is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell's nucleus. RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement, and the self-destruction of cells (apoptosis).

The MAP2K1 gene is very similar to a gene called MAP2K2, which provides instructions for making a protein known as MEK2 protein kinase. Like MEK1 protein kinase, this protein functions as part of the RAS/MAPK signaling pathway. Together, the MEK1 and MEK2 protein kinases appear to be essential for normal development before birth and for survival after birth.

Interactant

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