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MAP2K1 mitogen-activated protein kinase kinase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002755 Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol MAP2K1
Entrez Gene ID 5604
Full Name mitogen-activated protein kinase kinase 1
Synonyms MAPKK1, MEK1, MKK1, PRKMK1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22.1-q22.33

Summary The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].
Disorder

MIM: 176872

Cardiofaciocutaneous syndrome, 115150 (3)

mRNA Protein Product Sequence Price Select
NM_002755, 169790828 NP_002746, 5579478 dual specificity mitogen-activated protein kinase kinase 1 ORF Sequence $269.00
KEGG
hsa04916Melanogenesis
hsa05214Glioma
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa05219Bladder cancer
hsa04664Fc epsilon RI signaling pathway
hsa05215Prostate cancer
hsa04666Fc gamma R-mediated phagocytosis
hsa05212Pancreatic cancer
hsa04012ErbB signaling pathway
hsa05210Colorectal cancer
hsa04540Gap junction
hsa04662B cell receptor signaling pathway
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
hsa05211Renal cell carcinoma
hsa05221Acute myeloid leukemia
hsa04320Dorso-ventral axis formation
hsa04062Chemokine signaling pathway
hsa04720Long-term potentiation
hsa04370VEGF signaling pathway
hsa04726Serotonergic synapse
hsa05220Chronic myeloid leukemia
hsa04914Progesterone-mediated oocyte maturation
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa04910Insulin signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05213Endometrial cancer
hsa04620Toll-like receptor signaling pathway
hsa04730Long-term depression
hsa04066HIF-1 signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04725Cholinergic synapse
hsa05034Alcoholism
hsa05020Prion diseases
hsa04660T cell receptor signaling pathway
hsa05164Influenza A
hsa04114Oocyte meiosis
hsa04810Regulation of actin cytoskeleton
hsa05223Non-small cell lung cancer
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa05161Hepatitis B
hsa05218Melanoma
WikiPathways
WP422MAPK Cascade
WP2256Integrated Pancreatic Cancer Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP51Regulation of Actin Cytoskeleton
WP2377Integrated Pancreatic Cancer Pathway
WP22IL-9 Signaling Pathway
WP2324AGE/RAGE pathway
WP734Serotonin Receptor 4/6/7 and NR3C Signaling
WP437EGFR1 Signaling Pathway
WP2034Leptin signaling pathway
WP205IL-7 Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP313Signaling of Hepatocyte Growth Factor Receptor
WP382MAPK signaling pathway
WP304Kit Receptor Signaling Pathway
WP49IL-2 Signaling Pathway
WP666Hypothetical Network for Drug Addiction
WP185Integrin-mediated cell adhesion
WP286IL-3 Signaling Pathway
WP2018RANKL/RANK Signaling Pathway
WP2261Signaling Pathways in Glioblastoma
WP581EPO Receptor Signaling
WP2374Oncostatin M Signaling Pathway
WP306Focal Adhesion
WP481Insulin Signaling
WP712Estrogen signaling pathway
WP1434Osteopontin Signaling
WP259Nifedipine Activity
WP2037Prolactin Signaling Pathway
WP2197Endothelin
WP2032TSH signaling pathway
WP75Toll-like receptor signaling pathway
WP69TCR Signaling Pathway
WP364IL-6 Signaling Pathway
WP732Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP2203TSLP Signaling Pathway
WP673ErbB signaling pathway
WP615Senescence and Autophagy
Pathway Interaction Database
il2_1pathwayIL2-mediated signaling events
foxm1pathwayFOXM1 transcription factor network
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
ifngpathwayIFN-gamma pathway
pi3kcibpathwayClass IB PI3K non-lipid kinase events
anthraxpathwayCellular roles of Anthrax toxin
erbb1_downstream_pathwayErbB1 downstream signaling
fcer1pathwayFc-epsilon receptor I signaling in mast cells
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
mtor_4pathwaymTOR signaling pathway
ephbfwdpathwayEPHB forward signaling
cxcr3pathwayCXCR3-mediated signaling events
bcr_5pathwayBCR signaling pathway
endothelinpathwayEndothelins
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
fak_pathwaySignaling events mediated by focal adhesion kinase
erbb2erbb3pathwayErbB2/ErbB3 signaling events
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
tcrraspathwayRas signaling in the CD4+ TCR pathway
ceramide_pathwayCeramide signaling pathway
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
ar_nongenomic_pathwayNongenotropic Androgen signaling
BIOCYC
HUMAN_PWY66-14MAP kinase cascade
Reactome
REACT_18266Axon guidance
REACT_762IRS-related events
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_147694DAP12 interactions
REACT_16888Signaling by PDGF
REACT_115755Signaling by ERBB2
REACT_12005Prolonged ERK activation events
REACT_6966Toll Receptor Cascades
REACT_21308MAP kinase activation in TLR cascade
REACT_1391ERK1 activation
REACT_111040Signaling by SCF-KIT
REACT_6900Immune System
REACT_120736Signaling by FGFR in disease
REACT_999SHC-related events
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_22272Signal transduction by L1
REACT_111045Developmental Biology
REACT_115854GRB2 events in ERBB2 signaling
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_614RAF phosphorylates MEK
REACT_115596Signaling by ERBB4
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_12606GRB2 events in EGFR signaling
REACT_22205L1CAM interactions
REACT_116005SHC1 events in ERBB4 signaling
REACT_6890Activated TLR4 signalling
REACT_9470Signaling by FGFR
REACT_12579SHC1 events in EGFR signaling
REACT_147814DAP12 signaling
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_1482ERK activation
REACT_116125Disease
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_115993SHC1 events in ERBB2 signaling
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_524SOS-mediated signalling
REACT_75790Cytokine Signaling in Immune system
REACT_111102Signal Transduction
REACT_12077Signalling to p38 via RIT and RIN
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_661SHC-mediated signalling
REACT_12076Frs2-mediated activation
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_27283Interleukin-2 signaling
REACT_21272Downstream signaling of activated FGFR
REACT_6802Innate Immune System
REACT_115871Signaling by EGFR in Cancer
REACT_12002ARMS-mediated activation
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_12033Signalling to RAS
REACT_18334NCAM signaling for neurite out-growth
REACT_22442Interleukin-1 signaling
REACT_634RAF/MAP kinase cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_12058Signalling to ERKs
REACT_21247FRS2-mediated cascade
REACT_332IRS-mediated signalling
REACT_498Signaling by Insulin receptor
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_962MEK activation
REACT_22232Signaling by Interleukins
REACT_17025Downstream signal transduction
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
REACT_6809MyD88-independent cascade
Homo sapiens (human)MAP2K1NP_002746.1
Pan troglodytes (chimpanzee)MAP2K1NP_001009071.1
Macaca mulatta (Rhesus monkey)MAP2K1XP_001110225.1
Canis lupus familiaris (dog)MAP2K1NP_001041559.1
Bos taurus (cattle)MAP2K1NP_001124224.1
Mus musculus (house mouse)Map2k1NP_032953.1
Rattus norvegicus (Norway rat)Map2k1NP_113831.1
Gallus gallus (chicken)MAP2K1NP_001005830.1
Danio rerio (zebrafish)map2k1NP_998584.2
Drosophila melanogaster (fruit fly)Dsor1NP_511098.1
Caenorhabditis elegansmek-2NP_491087.1
Arabidopsis thaliana (thale cress)MKK2NP_001031751.1
Arabidopsis thaliana (thale cress)MEK1NP_194337.1
GeneCards MAP2K1
PDB 3EQG, 1S9J, 3ORN, 3DV3, 3V01, 4AN2, 3V04, 3DY7, 4ANB, 3EQH, 4ARK, 3OS3, 3EQC, 3EQI, 3SLS, 3E8N, 3MBL, 3EQD, 3EQF, 4AN3, 2P55, 3PP1, 3EQB, 4AN9
UniProt Q02750, A4QPA9
MIM 176872
Ensembl ENSG00000169032
HGNC 6840
HPRD 01469

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 1
Names
dual specificity mitogen-activated protein kinase kinase 1
MEK 1
MAPKK 1
MAPK/ERK kinase 1
ERK activator kinase 1
protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
NP_002746.1

Interactant



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