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PRL prolactin [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000948 Homo sapiens prolactin (PRL), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001163558 Homo sapiens prolactin (PRL), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Related Services

Gene Symbol PRL
Entrez Gene ID 5617
Full Name prolactin
Synonyms
General protein information
Preferred Names
prolactin
Names
prolactin
decidual prolactin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.3

Summary This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].
Disorder

MIM: 176760

mRNA Protein Product Sequence Price Select
NM_000948, 344217720 NP_000939, 4506105 prolactin precursor ORF Sequence $159.00
NM_001163558, 344217721 NP_001157030, 254675133 prolactin precursor ORF Sequence $159.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04917Prolactin signaling pathway
WikiPathways
WP98Prostaglandin Synthesis and Regulation
WP2037Prolactin Signaling Pathway
Pathway Interaction Database
erbb4_pathwayErbB4 signaling events
ptp1bpathwaySignaling events mediated by PTP1B
reg_gr_pathwayGlucocorticoid receptor regulatory network
Reactome
REACT_6900Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_75925Amyloids
REACT_111133Growth hormone receptor signaling
REACT_111102Signal Transduction
REACT_116125Disease
REACT_115697Prolactin receptor signaling
REACT_115596Signaling by ERBB4
REACT_116022Nuclear signaling by ERBB4
Homo sapiens (human)PRLNP_001157030.1
Pan troglodytes (chimpanzee)PRLXP_518264.1
Macaca mulatta (Rhesus monkey)PRLNP_001040593.1
Canis lupus familiaris (dog)PRLNP_001008276.2
Bos taurus (cattle)PRLNP_776378.2
Mus musculus (house mouse)PrlNP_035294.2
Rattus norvegicus (Norway rat)PrlNP_036761.1
Gallus gallus (chicken)PRLNP_990797.2
Xenopus (Silurana) tropicalis (western clawed frog)prl.1NP_001093699.1
Process
IDNameEvidence
GO:0007166cell surface receptor signaling pathwayTAS
GO:0007565female pregnancyNAS
GO:0007595lactationIEA
GO:0008283cell proliferationTAS
GO:0040014regulation of multicellular organism growthIEP
GO:0046427positive regulation of JAK-STAT cascadeIDA
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTAS
Component
IDNameEvidence
GO:0005576extracellular regionTAS
Function
IDNameEvidence
GO:0005148prolactin receptor bindingTAS
GO:0005179hormone activityIEA
GO:0005515protein bindingIPI
GeneCards PRL
PDB 3EW3, 3NCB, 3N0P, 3N06, 3NPZ, 3NCF, 3NCC, 3D48, 3NCE, 1RW5, 3MZG, 2Q98
UniProt Q5THQ0, P01236
Vega OTTHUMG00000016111
MIM 176760
Ensembl ENSG00000172179
HGNC 9445
HPRD 07180

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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