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PROC protein C (inactivator of coagulation factors Va and VIIIa) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000312 Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol PROC
Entrez Gene ID 5624
Full Name protein C (inactivator of coagulation factors Va and VIIIa)
Synonyms APC, PC, PROC1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q13-q14

Summary This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].
Disorder

MIM: 612283

Thrombophilia due to protein C deficiency, autosomal dominant,

mRNA Protein Product Sequence Price Select
NM_000312, 270483720 NP_000303, 4506115 vitamin K-dependent protein C preproprotein ORF Sequence $550.00
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP558Complement and Coagulation Cascades
Reactome
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
REACT_1439Common Pathway
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1050Gamma-carboxylation of protein precursors
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_12051Cell surface interactions at the vascular wall
REACT_604Hemostasis
REACT_22161Post-translational protein modification
REACT_17015Metabolism of proteins
REACT_1069PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Homo sapiens (human)PROCNP_000303.1
Pan troglodytes (chimpanzee)PROCXP_515775.3
Macaca mulatta (Rhesus monkey)PROCXP_001087196.2
Canis lupus familiaris (dog)PROCNP_001013871.1
Bos taurus (cattle)PROCNP_001159984.1
Mus musculus (house mouse)ProcNP_032960.3
Rattus norvegicus (Norway rat)ProcNP_036935.1
Gallus gallus (chicken)PROCNP_989772.1
Danio rerio (zebrafish)procNP_956650.1
Danio rerio (zebrafish)LOC798775XP_001334094.3
GeneCards PROC
PDB 1LQV, 3F6U, 3JTC, 1AUT, 2PCT, 1PCU, 4DT7
UniProt P04070
MIM 612283
Ensembl ENSG00000115718
HGNC 9451
HPRD 01466

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
vitamin K-dependent protein C
Names
vitamin K-dependent protein C
autoprothrombin IIA
anticoagulant protein C
blood coagulation factor XIV
NP_000303.1

Interactant



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