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PROC protein C (inactivator of coagulation factors Va and VIIIa) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20007 NM_000312 Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu36435 XM_005263715 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu36436 XM_005263716 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu36437 XM_005263717 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu36438 XM_006712633 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20007C NM_000312 Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), mRNA. Customized vector On-demand 7-9 $269.00
OHu36435C XM_005263715 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu36436C XM_005263716 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X2, mRNA. Customized vector On-demand TBD $269.00
OHu36437C XM_005263717 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00
OHu36438C XM_006712633 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X4, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol PROC
Entrez Gene ID 5624
Full Name protein C (inactivator of coagulation factors Va and VIIIa)
Synonyms APC, PC, PROC1, THPH3, THPH4
General protein information
Preferred Names
vitamin K-dependent protein C
Names
vitamin K-dependent protein C
autoprothrombin IIA
anticoagulant protein C
blood coagulation factor XIV
NP_000303.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q13-q14

Summary This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].
Disorder

MIM: 612283

Thrombophilia due to protein C deficiency, autosomal dominant,

mRNA Protein Product Sequence Price Select
NM_000312, 270483720 NP_000303, 4506115 vitamin K-dependent protein C preproprotein ORF Sequence $550.00
XM_005263715, 578804595 XP_005263772, 530369294 vitamin K-dependent protein C isoform X1 ORF Sequence $550.00
XM_005263716, 578804596 XP_005263773, 530369296 vitamin K-dependent protein C isoform X2 ORF Sequence $550.00
XM_005263717, 578804597 XP_005263774, 530369298 vitamin K-dependent protein C isoform X3 ORF Sequence $550.00
XM_006712633, 578804598 XP_006712696, 578804599 vitamin K-dependent protein C isoform X4 ORF Sequence $550.00
KEGG
hsa04610Complement and coagulation cascades
Reactome
REACT_604Hemostasis
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1439Common Pathway
REACT_12051Cell surface interactions at the vascular wall
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_1050Gamma-carboxylation of protein precursors
REACT_17015Metabolism of proteins
REACT_1069PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_22161Post-translational protein modification
Homo sapiens (human)PROCNP_000303.1
Pan troglodytes (chimpanzee)PROCXP_515775.3
Macaca mulatta (Rhesus monkey)PROCXP_001087196.2
Canis lupus familiaris (dog)LOC476104NP_001013871.1
Bos taurus (cattle)PROCNP_001159984.1
Mus musculus (house mouse)ProcNP_032960.3
Rattus norvegicus (Norway rat)ProcNP_036935.1
Gallus gallus (chicken)PROCNP_989772.1
Danio rerio (zebrafish)procaNP_956650.1
Xenopus (Silurana) tropicalis (western clawed frog)procNP_001015759.1
Process
IDNameEvidence
GO:0006508proteolysisNAS
GO:0006508proteolysisTAS
GO:0007596blood coagulationTAS
GO:0017187peptidyl-glutamic acid carboxylationTAS
GO:0030195negative regulation of blood coagulationTAS
GO:0043066negative regulation of apoptotic processIMP
GO:0043687post-translational protein modificationTAS
GO:0044267cellular protein metabolic processTAS
GO:0050900leukocyte migrationTAS
Component
IDNameEvidence
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005788endoplasmic reticulum lumenTAS
GO:0005796Golgi lumenTAS
GO:0005886plasma membraneTAS
Function
IDNameEvidence
GO:0004252serine-type endopeptidase activityTAS
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GeneCards PROC
PDB 1LQV, 3F6U, 3JTC, 1AUT, 2PCT, 1PCU, 4DT7
UniProt P04070
Vega OTTHUMG00000131528
MIM 612283
Ensembl ENSG00000115718
HGNC 9451
HPRD 01466

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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