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PROS1 protein S (alpha) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21617 NM_000313 Homo sapiens protein S (alpha) (PROS1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu38054 XM_005247626 PREDICTED: Homo sapiens protein S (alpha) (PROS1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu21617C NM_000313 Homo sapiens protein S (alpha) (PROS1), mRNA. Customized vector In-stock 5-7 $149.00
OHu38054C XM_005247626 PREDICTED: Homo sapiens protein S (alpha) (PROS1), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol PROS1
Entrez Gene ID 5627
Full Name protein S (alpha)
Synonyms PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
General protein information
Preferred Names
vitamin K-dependent protein S
Names
vitamin K-dependent protein S
protein Sa
vitamin K-dependent plasma protein S
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q11.2

Summary This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009].
Disorder

MIM: 176880

Thrombophilia due to protein S deficiency, 612336 (3)

mRNA Protein Product Sequence Price Select
NM_000313, 223671900 NP_000304, 192447438 vitamin K-dependent protein S preproprotein ORF Sequence $490.00
XM_005247626, 578807587 XP_005247683, 530374971 vitamin K-dependent protein S isoform X1 ORF Sequence $700.00
KEGG
hsa04610Complement and coagulation cascades
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1439Common Pathway
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_12051Cell surface interactions at the vascular wall
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_1050Gamma-carboxylation of protein precursors
REACT_17015Metabolism of proteins
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6932Complement cascade
REACT_1069PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_22161Post-translational protein modification
REACT_118707Regulation of Complement cascade
Homo sapiens (human)PROS1NP_000304.2
Pan troglodytes (chimpanzee)PROS1XP_516603.3
Macaca mulatta (Rhesus monkey)PROS1NP_001038191.1
Canis lupus familiaris (dog)PROS1XP_005639500.1
Bos taurus (cattle)PROS1NP_776863.1
Mus musculus (house mouse)Pros1NP_035303.1
Rattus norvegicus (Norway rat)Pros1NP_112348.2
Gallus gallus (chicken)PROS1XP_416641.2
Danio rerio (zebrafish)pros1NP_001070791.1
Xenopus (Silurana) tropicalis (western clawed frog)pros1NP_001119539.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0006508proteolysisTAS
GO:0007596blood coagulationTAS
GO:0010951negative regulation of endopeptidase activityTAS
GO:0017187peptidyl-glutamic acid carboxylationTAS
GO:0030168platelet activationTAS
GO:0030449regulation of complement activationTAS
GO:0042730fibrinolysisIEA
GO:0043687post-translational protein modificationTAS
GO:0044267cellular protein metabolic processTAS
GO:0045087innate immune responseTAS
GO:0050900leukocyte migrationTAS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005789endoplasmic reticulum membraneTAS
GO:0005796Golgi lumenTAS
GO:0031093platelet alpha granule lumenTAS
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0004866endopeptidase inhibitor activityTAS
GO:0005509calcium ion bindingIEA
GeneCards PROS1
PDB 1Z6C
UniProt P07225
Vega OTTHUMG00000150354
MIM 176880
Ensembl ENSG00000184500
HGNC 9456
HPRD 01473

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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