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PRSS1 protease, serine, 1 (trypsin 1) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002769 Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol PRSS1
Entrez Gene ID 5644
Full Name protease, serine, 1 (trypsin 1)
Synonyms TRP1, TRY1, TRY4, TRYP1
General protein information
Preferred Names
trypsinogen 1
trypsinogen A
digestive zymogen
cationic trypsinogen
nonfunctional trypsin 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].

MIM: 276000

Trypsinogen deficiency (1); Pancreatitis, hereditary, 167800 (3)

mRNA Protein Product Sequence Price Select
NM_002769, 310923201 NP_002760, 4506145 trypsin-1 preproprotein ORF Sequence $250.00
hsa04080Neuroactive ligand-receptor interaction
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
hsa05164Influenza A
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_11193Metabolism of vitamins and cofactors
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_118682Activation of Matrix Metalloproteinases
REACT_163862Cobalamin (Cbl, vitamin B12) transport and metabolism
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169385Defects in vitamin and cofactor metabolism
REACT_169238Defects in biotin (Btn) metabolism
REACT_169403Defective BTD causes biotidinase deficiency
Homo sapiens (human)PRSS1NP_002760.1
Pan troglodytes (chimpanzee)LOC100615987XP_003318897.1
Pan troglodytes (chimpanzee)LOC742453XP_003951210.1
Macaca mulatta (Rhesus monkey)PRSS1NP_001040586.1
Mus musculus (house mouse)Try10NP_001034085.1
Drosophila melanogaster (fruit fly)CG10663NP_001097592.1
GO:0006766vitamin metabolic processTAS
GO:0006767water-soluble vitamin metabolic processTAS
GO:0009235cobalamin metabolic processTAS
GO:0022617extracellular matrix disassemblyTAS
GO:0030198extracellular matrix organizationTAS
GO:0044281small molecule metabolic processTAS
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
GO:0004252serine-type endopeptidase activityTAS
GO:0046872metal ion bindingIEA
GeneCards PRSS1
UniProt P07477
Vega OTTHUMG00000158923
MIM 276000
Ensembl ENSG00000204983
HGNC 9475
HPRD 02039

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PRSS1 gene?

The PRSS1 gene provides instructions for making an enzyme called cationic trypsinogen. This enzyme is a serine peptidase, which is a type of enzyme that cuts (cleaves) other proteins into smaller pieces. Cationic trypsinogen is produced in the pancreas and helps with the digestion of food. Cationic trypsinogen is secreted by the pancreas and transported to the small intestine, where it is cleaved to form trypsinogen. When the enzyme is needed, trypsinogen is cleaved again into its working (active) form called trypsin. Trypsin aids in digestion by cutting protein chains at the protein building blocks (amino acids) arginine or lysine, which breaks down the protein. Trypsin also turns on (activates) other digestive enzymes that are produced in the pancreas to further facilitate digestion.

A particular region of trypsin is attached (bound) to a calcium molecule. As long as trypsin is bound to calcium, the enzyme is protected from being broken down. When digestion is complete and trypsin is no longer needed, the calcium molecule is removed from the enzyme, which allows trypsin to be broken down.


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