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PRSS1 protease, serine, 1 (trypsin 1) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002769 Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), mRNA. ORF Sequence $215.76
Peptide Services
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Gene Symbol PRSS1
Entrez Gene ID 5644
Full Name protease, serine, 1 (trypsin 1)
Synonyms DKFZp779A0837, FLJ57296, MGC120175, MGC149362, TRP1, TRY1, TRY4, TRYP1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q32-qter|7q34

Summary This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].
Disorder

MIM: 276000

Trypsinogen deficiency (1); Pancreatitis, hereditary, 167800 (3)

mRNA Protein Product Sequence Price Select
NM_002769, 310923201 NP_002760, 4506145 trypsin-1 preproprotein Full Length $240.99
ORF Sequence $215.76
KEGG
hsa04974Protein digestion and absorption
hsa04080Neuroactive ligand-receptor interaction
hsa05164Influenza A
hsa04972Pancreatic secretion
Reactome
REACT_118779Extracellular matrix organization
REACT_118682Activation of Matrix Metalloproteinases
REACT_118572Degradation of the extracellular matrix
Homo sapiens (human)PRSS1NP_002760.1
Pan troglodytes (chimpanzee)LOC742453XP_001160583.2
Macaca mulatta (Rhesus monkey)PRSS1NP_001040586.1
Canis lupus familiaris (dog)PRSS1XP_532744.1
Bos taurus (cattle)LOC615026XP_002687054.2
Bos taurus (cattle)LOC780933NP_001107199.1
Mus musculus (house mouse)2210010C04RikNP_075822.3
Rattus norvegicus (Norway rat)Prss3NP_775150.1
Gallus gallus (chicken)PRSS3NP_990716.1
Gallus gallus (chicken)LOC768817XP_001231433.2
Gallus gallus (chicken)LOC100857124XP_003640494.1
Danio rerio (zebrafish)tryNP_571783.1
Drosophila melanogaster (fruit fly)betaTryNP_524904.1
Drosophila melanogaster (fruit fly)alphaTryNP_476771.1
Drosophila melanogaster (fruit fly)deltaTryNP_523694.2
Drosophila melanogaster (fruit fly)gammaTryNP_725034.1
Drosophila melanogaster (fruit fly)CG17571NP_610109.1
Drosophila melanogaster (fruit fly)thetaTryNP_523693.1
Drosophila melanogaster (fruit fly)iotaTryNP_523695.1
Drosophila melanogaster (fruit fly)CG17239NP_722784.1
Drosophila melanogaster (fruit fly)Ser12NP_523456.1
Drosophila melanogaster (fruit fly)Ser8NP_610874.1
Drosophila melanogaster (fruit fly)CG30031NP_725035.1
Drosophila melanogaster (fruit fly)CG30025NP_725036.1
Drosophila melanogaster (fruit fly)epsilonTryNP_525112.1
GeneCards PRSS1
PDB 2RA3, 1TRN, 1FXY
UniProt P07477
MIM 276000
Ensembl ENSG00000204983
HGNC 9475
HPRD 02039

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
trypsin-1
Names
trypsin-1
beta-trypsin
trypsinogen 1
trypsinogen A
digestive zymogen
cationic trypsinogen
nonfunctional trypsin 1
NP_002760.1

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