PRSS1 protease, serine, 1 (trypsin 1) [Homo sapiens (human)]
| Gene Symbol | PRSS1 |
| Entrez Gene ID | 5644 |
| Full Name | protease, serine, 1 (trypsin 1) |
| Synonyms | DKFZp779A0837, FLJ57296, MGC120175, MGC149362, TRP1, TRY1, TRY4, TRYP1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
7 7q32-qter|7q34 |
| Summary | This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq]. |
| Disorder | MIM: 276000 Trypsinogen deficiency (1); Pancreatitis, hereditary, 167800 (3) |
| mRNA | NM_002769, 310923201 |
| Protein | NP_002760, 4506145 |
| Product | trypsin-1 preproprotein |
| RefSeq Status | REVIEWED |
| hsa04972 | Pancreatic secretion |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04974 | Protein digestion and absorption |
| Homo sapiens (human) | PRSS1 | NP_002760.1 |
| Homo sapiens (human) | PRSS3 | NP_002762.2 |
| Pan troglodytes (chimpanzee) | PRSS3 | XP_001155576.1 |
| Bos taurus (cattle) | PRSS2 | NP_777115.1 |
| Mus musculus (house mouse) | Prss2 | NP_033456.1 |
| Rattus norvegicus (Norway rat) | Prss1 | NP_036767.1 |
| Gallus gallus (chicken) | PRSS2 | NP_990715.1 |
| Danio rerio (zebrafish) | zgc:66382 | NP_955899.1 |
| ID | Name | Evidence |
| GO:0006508 | proteolysis | IEA |
| GO:0007586 | digestion | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | NAS |
| GO:0005615 | extracellular space | IEA |
Function
| ID | Name | Evidence |
| GO:0004252 | serine-type endopeptidase activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0008233 | peptidase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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