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RELN reelin [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22578 NM_005045 Homo sapiens reelin (RELN), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22822 NM_173054 Homo sapiens reelin (RELN), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22578C NM_005045 Homo sapiens reelin (RELN), transcript variant 1, mRNA. Customized vector On-demand TBD TBD
OHu22822C NM_173054 Homo sapiens reelin (RELN), transcript variant 2, mRNA. Customized vector On-demand TBD TBD

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Gene Symbol RELN
Entrez Gene ID 5649
Full Name reelin
Synonyms LIS2, PRO1598, RL
General protein information
Preferred Names
reelin
Names
reelin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22

Summary This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600514

Lissencephaly syndrome, Norman-Roberts type, 257320 (3)

mRNA Protein Product Sequence Price Select
NM_005045, 223718138 NP_005036, 27436938 reelin isoform a precursor ORF Sequence $-1.00
NM_173054, 223718142 NP_774959, 27436940 reelin isoform b precursor ORF Sequence $-1.00
KEGG
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04151PI3K-Akt signaling pathway
Pathway Interaction Database
reelinpathwayReelin signaling pathway
lis1pathwayLissencephaly gene (LIS1) in neuronal migration and development
Homo sapiens (human)RELNNP_005036.2
Pan troglodytes (chimpanzee)RELNXP_519291.3
Macaca mulatta (Rhesus monkey)RELNXP_001087945.1
Canis lupus familiaris (dog)RELNXP_849464.1
Bos taurus (cattle)RELNNP_001193387.1
Mus musculus (house mouse)RelnNP_035391.2
Rattus norvegicus (Norway rat)RelnNP_536319.2
Gallus gallus (chicken)RELNXP_425424.3
Danio rerio (zebrafish)relnNP_001233205.1
Xenopus (Silurana) tropicalis (western clawed frog)relnNP_001131084.1
Process
IDNameEvidence
GO:0000904cell morphogenesis involved in differentiationISS
GO:0001764neuron migrationISS
GO:0006508proteolysisIEA
GO:0007155cell adhesionIEA
GO:0007411axon guidanceISS
GO:0007417central nervous system developmentISS
GO:0007420brain developmentISS
GO:0007616long-term memoryIEA
GO:0008306associative learningIEA
GO:0010001glial cell differentiationISS
GO:0010976positive regulation of neuron projection developmentISS
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIEA
GO:0016358dendrite developmentIEA
GO:0018108peptidyl-tyrosine phosphorylationISS
GO:0021511spinal cord patterningISS
GO:0021517ventral spinal cord developmentIEA
GO:0021766hippocampus developmentISS
GO:0021800cerebral cortex tangential migrationISS
GO:0032008positive regulation of TOR signalingIEA
GO:0032793positive regulation of CREB transcription factor activityISS
GO:0038026reelin-mediated signaling pathwayISS
GO:0045860positive regulation of protein kinase activityISS
GO:0048265response to painISS
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISS
GO:0050795regulation of behaviorISS
GO:0050804regulation of synaptic transmissionISS
GO:0051057positive regulation of small GTPase mediated signal transductionISS
GO:0051968positive regulation of synaptic transmission, glutamatergicISS
GO:0061003positive regulation of dendritic spine morphogenesisISS
GO:0061098positive regulation of protein tyrosine kinase activityISS
GO:0090129positive regulation of synapse maturationISS
GO:0097114N-methyl-D-aspartate receptor clusteringIEA
GO:0097119postsynaptic density protein 95 clusteringIEA
GO:0097120receptor localization to synapseIEA
GO:0097477lateral motor column neuron migrationIEA
GO:1900273positive regulation of long-term synaptic potentiationISS
GO:1902078positive regulation of lateral motor column neuron migrationIEA
GO:2000310regulation of N-methyl-D-aspartate selective glutamate receptor activityISS
GO:2000463positive regulation of excitatory postsynaptic membrane potentialISS
GO:2000969positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISS
Component
IDNameEvidence
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceISS
GO:0005737cytoplasmISS
GO:0030425dendriteISS
Function
IDNameEvidence
GO:0004712protein serine/threonine/tyrosine kinase activityISS
GO:0008236serine-type peptidase activityIEA
GO:0046872metal ion bindingIEA
GO:0070325lipoprotein particle receptor bindingISS
GO:0070326very-low-density lipoprotein particle receptor bindingISS
GeneCards RELN
UniProt P78509
Vega OTTHUMG00000157247
MIM 600514
Ensembl ENSG00000189056
HGNC 9957
HPRD 02742

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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