RTN4 reticulon 4 [Homo sapiens (human)]

Gene Symbol	RTN4
Entrez Gene ID	57142
Full Name	reticulon 4
Synonyms	ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:2 Map Location:2p16.3
Summary	This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq].
Disorder	MIM: 604475

Pathway Interaction Database

p75ntrpathway

p75(NTR)-mediated signaling

Reactome

REACT_11061	Signalling by NGF
REACT_13776	p75 NTR receptor-mediated signalling
REACT_13815	Axonal growth inhibition (RHOA activation)
REACT_13620	p75NTR regulates axonogenesis

Homo sapiens (human)	RTN4	NP_065393.1
Canis lupus familiaris (dog)	RTN4	XP_852236.1
Mus musculus (house mouse)	Rtn4	NP_918943.1
Rattus norvegicus (Norway rat)	Rtn4	NP_114019.1
Gallus gallus (chicken)	RTN4	NP_989697.2

Process

ID	Name	Evidence
GO:0001525	angiogenesis	IEA
GO:0006915	apoptosis	NAS
GO:0007413	axonal fasciculation	ISS
GO:0007568	aging	IEA
GO:0014823	response to activity	IEA
GO:0019987	negative regulation of anti-apoptosis	IMP
GO:0021553	olfactory nerve development	IEA
GO:0021801	cerebral cortex radial glia guided migration	ISS
GO:0030308	negative regulation of cell growth	IMP
GO:0030334	regulation of cell migration	IDA
GO:0030517	negative regulation of axon extension	IDA
GO:0033603	positive regulation of dopamine secretion	IEA
GO:0042981	regulation of apoptosis	NAS
GO:0045665	negative regulation of neuron differentiation	IEA
GO:0045687	positive regulation of glial cell differentiation	IEA
GO:0048011	nerve growth factor receptor signaling pathway	TAS
GO:0048679	regulation of axon regeneration	IEA
GO:0048709	oligodendrocyte differentiation	IEA
GO:0050770	regulation of axonogenesis	EXP
GO:0050771	negative regulation of axonogenesis	EXP
GO:0051930	regulation of sensory perception of pain	IEA
GO:0060317	cardiac epithelial to mesenchymal transition	IEA
GO:0070571	negative regulation of neuron projection regeneration	IEA
GO:0071786	endoplasmic reticulum tubular network organization	IMP
GO:2000172	regulation of branching morphogenesis of a nerve	ISS

Component

ID	Name	Evidence
GO:0005635	nuclear envelope	IDA
GO:0005737	cytoplasm	IEA
GO:0005783	endoplasmic reticulum	NAS
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0005886	plasma membrane	EXP
GO:0016021	integral to membrane	IEA
GO:0030176	integral to endoplasmic reticulum membrane	IDA
GO:0043005	neuron projection	IEA
GO:0043025	neuronal cell body	IEA
GO:0043209	myelin sheath	IEA
GO:0043234	protein complex	IEA

Function

RefSeq Accession	Definition	Sequence	Price	Select
NM_020532	Homo sapiens reticulon 4 (RTN4), transcript variant 1, mRNA.	Full Length	$1704.85
NM_020532		ORF Sequence	$1252.65
NM_207520	Homo sapiens reticulon 4 (RTN4), transcript variant 4, mRNA.	Full Length	$716.59
NM_207520		ORF Sequence	$341.91
NM_153828	Homo sapiens reticulon 4 (RTN4), transcript variant 2, mRNA.	Full Length	$700.06
NM_153828		ORF Sequence	$325.38
NM_007008	Homo sapiens reticulon 4 (RTN4), transcript variant 3, mRNA.	Full Length	$524.32
NM_007008		ORF Sequence	$174.00
NM_207521	Homo sapiens reticulon 4 (RTN4), transcript variant 5, mRNA.	Full Length	$1445.15
NM_207521		ORF Sequence	$858.69