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RTN4 reticulon 4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu15728 NM_153828 Homo sapiens reticulon 4 (RTN4), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu15762 NM_007008 Homo sapiens reticulon 4 (RTN4), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu15795 NM_207521 Homo sapiens reticulon 4 (RTN4), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu15978 NM_207520 Homo sapiens reticulon 4 (RTN4), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu19329 NM_020532 Homo sapiens reticulon 4 (RTN4), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu15795 XM_005264434 PREDICTED: Homo sapiens reticulon 4 (RTN4), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu15728C NM_153828 Homo sapiens reticulon 4 (RTN4), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu15762C NM_007008 Homo sapiens reticulon 4 (RTN4), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu15795C NM_207521 Homo sapiens reticulon 4 (RTN4), transcript variant 5, mRNA. Customized vector On-demand 12-14 $329.00
OHu15978C NM_207520 Homo sapiens reticulon 4 (RTN4), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu19329C NM_020532 Homo sapiens reticulon 4 (RTN4), transcript variant 1, mRNA. Customized vector On-demand -1 TBD
OHu15795C XM_005264434 PREDICTED: Homo sapiens reticulon 4 (RTN4), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol RTN4
Entrez Gene ID 57142
Full Name reticulon 4
Synonyms ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
General protein information
Preferred Names
reticulon-4
Names
reticulon-4
foocen
Human NogoA
reticulon 5
My043 protein
neurite outgrowth inhibitor
neurite growth inhibitor 220
neuroendocrine-specific protein C homolog
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p16.3

Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604475

mRNA Protein Product Sequence Price Select
NM_007008, 47519538 NP_008939, 5902016 reticulon-4 isoform C ORF Sequence $159.00
NM_020532, 47519458 NP_065393, 24431935 reticulon-4 isoform A ORF Sequence $1500.00
NM_153828, 47519507 NP_722550, 24431933 reticulon-4 isoform B ORF Sequence $400.00
NM_207520, 47519489 NP_997403, 47519490 reticulon-4 isoform D ORF Sequence $400.00
NM_207521, 47519561 NP_997404, 47519562 reticulon-4 isoform E ORF Sequence $750.00
XM_005264434, 578803013 XP_005264491, 530367842 reticulon-4 isoform X1 ORF Sequence $750.00
WikiPathways
WP2431Spinal Cord Injury
Pathway Interaction Database
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_13620p75NTR regulates axonogenesis
REACT_13815Axonal growth inhibition (RHOA activation)
REACT_111102Signal Transduction
Homo sapiens (human)RTN4NP_065393.1
Macaca mulatta (Rhesus monkey)RTN4XP_001112090.2
Canis lupus familiaris (dog)RTN4XP_531828.2
Bos taurus (cattle)RTN4NP_001106692.1
Mus musculus (house mouse)Rtn4NP_918943.1
Rattus norvegicus (Norway rat)Rtn4NP_114019.1
Gallus gallus (chicken)LOC101749579XP_004940228.1
Xenopus (Silurana) tropicalis (western clawed frog)rtn4NP_001161159.1
Process
IDNameEvidence
GO:0001525angiogenesisIEA
GO:0006915apoptotic processNAS
GO:0007413axonal fasciculationISS
GO:0021801cerebral cortex radial glia guided migrationISS
GO:0030308negative regulation of cell growthIMP
GO:0030334regulation of cell migrationIDA
GO:0030517negative regulation of axon extensionIDA
GO:0042981regulation of apoptotic processNAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0050770regulation of axonogenesisTAS
GO:0050771negative regulation of axonogenesisTAS
GO:0060317cardiac epithelial to mesenchymal transitionIEA
GO:0071786endoplasmic reticulum tubular network organizationIMP
GO:2000172regulation of branching morphogenesis of a nerveISS
Component
IDNameEvidence
GO:0005622intracellularIMP
GO:0005635nuclear envelopeIDA
GO:0005783endoplasmic reticulumIDA
GO:0005783endoplasmic reticulumNAS
GO:0005886plasma membraneTAS
GO:0030176integral component of endoplasmic reticulum membraneIDA
GO:0042995cell projectionIEA
GO:0043025neuronal cell bodyIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0044822poly(A) RNA bindingIDA
GeneCards RTN4
UniProt Q9NQC3
Vega OTTHUMG00000129337
MIM 604475
Ensembl ENSG00000115310
HGNC 14085
HPRD 07259

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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