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JPH2 junctophilin 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu07425 NM_175913 Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu19281 NM_020433 Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu19281 XM_006723832 PREDICTED: Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu53055 XM_006723833 PREDICTED: Homo sapiens junctophilin 2 (JPH2), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu07425C NM_175913 Homo sapiens junctophilin 2 (JPH2), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu19281C NM_020433 Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA. Customized vector On-demand TBD $329.00
OHu19281C XM_006723832 PREDICTED: Homo sapiens junctophilin 2 (JPH2), transcript variant X1, mRNA. Customized vector On-demand TBD $329.00
OHu53055C XM_006723833 PREDICTED: Homo sapiens junctophilin 2 (JPH2), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol JPH2
Entrez Gene ID 57158
Full Name junctophilin 2
Synonyms CMH17, JP-2, JP2
General protein information
Preferred Names
junctophilin-2
Names
junctophilin-2
junctophilin type 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.12

Summary Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605267

mRNA Protein Product Sequence Price Select
NM_020433, 61699223 NP_065166, 21704281 junctophilin-2 isoform 1 ORF Sequence $700.00
NM_175913, 61699222 NP_787109, 29893812 junctophilin-2 isoform 2 ORF Sequence $150.00
XM_006723832, 578836082 XP_006723895, 578836083 junctophilin-2 isoform X1 ORF Sequence $700.00
XM_006723833, 578836084 XP_006723896, 578836085 junctophilin-2 isoform X2 ORF Sequence $150.00
Homo sapiens (human)JPH2NP_065166.2
Pan troglodytes (chimpanzee)JPH2XP_525332.2
Macaca mulatta (Rhesus monkey)JPH2XP_001083346.1
Bos taurus (cattle)JPH2XP_002692371.3
Mus musculus (house mouse)Jph2NP_001192005.1
Rattus norvegicus (Norway rat)Jph2NP_001033063.1
Gallus gallus (chicken)JPH2XP_001234186.3
Danio rerio (zebrafish)jph2NP_001082833.1
Xenopus (Silurana) tropicalis (western clawed frog)jph2XP_002933232.1
Process
IDNameEvidence
GO:0055024regulation of cardiac muscle tissue developmentIEA
GO:0055074calcium ion homeostasisIDA
GO:0060314regulation of ryanodine-sensitive calcium-release channel activityTAS
GO:0060316positive regulation of ryanodine-sensitive calcium-release channel activityIDA
GO:0060402calcium ion transport into cytosolTAS
GO:0070588calcium ion transmembrane transportIDA
GO:0070588calcium ion transmembrane transportIEA
Component
IDNameEvidence
GO:0005886plasma membraneIEA
GO:0014701junctional sarcoplasmic reticulum membraneTAS
GO:0016021integral component of membraneIEA
GO:0030018Z discIEA
GO:0030314junctional membrane complexIEA
Function
IDNameEvidence
GO:0001786phosphatidylserine bindingIDA
GO:0005515protein bindingIPI
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingIDA
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingIDA
GO:0010314phosphatidylinositol-5-phosphate bindingIDA
GO:0015278calcium-release channel activityIDA
GO:0032266phosphatidylinositol-3-phosphate bindingIDA
GO:0070273phosphatidylinositol-4-phosphate bindingIDA
GO:0070300phosphatidic acid bindingIDA
GO:0080025phosphatidylinositol-3,5-bisphosphate bindingIDA
GeneCards JPH2
UniProt Q86VZ3, Q9BR39
Vega OTTHUMG00000033037
MIM 605267
Ensembl ENSG00000149596
HGNC 14202
HPRD 12006

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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