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SALL4 spalt-like transcription factor 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_020436 Homo sapiens spalt-like transcription factor 4 (SALL4), mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005260467 PREDICTED: Homo sapiens spalt-like transcription factor 4 (SALL4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006723834 PREDICTED: Homo sapiens spalt-like transcription factor 4 (SALL4), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006723835 PREDICTED: Homo sapiens spalt-like transcription factor 4 (SALL4), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol SALL4
Entrez Gene ID 57167
Full Name spalt-like transcription factor 4
Synonyms DRRS, HSAL4, ZNF797, dJ1112F19.1
General protein information
Preferred Names
sal-like protein 4
Names
sal-like protein 4
zinc finger protein 797
zinc finger protein SALL4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.2

Summary The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). [provided by RefSeq, Jul 2008].
Disorder

MIM: 607343

Duane-radial ray syndrome, 607323 (3); IVIC syndrome, 147750 (3)

mRNA Protein Product Sequence Price Select
NM_020436, 187173293 NP_065169, 10047144 sal-like protein 4 ORF Sequence $1500.00
XM_005260467, 530418219 XP_005260524, 530418220 sal-like protein 4 isoform X1 ORF Sequence $750.00
XM_006723834, 578836086 XP_006723897, 578836087 sal-like protein 4 isoform X2 ORF Sequence $750.00
XM_006723835, 578836088 XP_006723898, 578836089 sal-like protein 4 isoform X3 ORF Sequence $750.00
Pathway Interaction Database
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Reactome
REACT_111045Developmental Biology
REACT_200812Transcriptional regulation of pluripotent stem cells
Homo sapiens (human)SALL4NP_065169.1
Pan troglodytes (chimpanzee)SALL4XP_514728.2
Macaca mulatta (Rhesus monkey)SALL4XP_001093669.1
Canis lupus familiaris (dog)SALL4XP_543055.2
Bos taurus (cattle)SALL4NP_001179765.1
Mus musculus (house mouse)Sall4NP_780512.2
Rattus norvegicus (Norway rat)Sall4XP_003749680.1
Gallus gallus (chicken)SALL4NP_001074341.1
Danio rerio (zebrafish)sall4NP_001074078.1
Xenopus (Silurana) tropicalis (western clawed frog)sall4NP_001001458.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001833inner cell mass cell proliferationIEA
GO:0001843neural tube closureIEA
GO:0003281ventricular septum developmentIEA
GO:0006351transcription, DNA-templatedIEA
GO:0019827stem cell maintenanceIEA
GO:0030326embryonic limb morphogenesisIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
Component
IDNameEvidence
GO:0000792heterochromatinIEA
GO:0005634nucleusIEA
GO:0005737cytoplasmIEA
GO:0043234protein complexIEA
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0046872metal ion bindingIEA
GeneCards SALL4
UniProt Q9UJQ4
Vega OTTHUMG00000032752
MIM 607343
Ensembl ENSG00000101115
HGNC 15924
HPRD 08458

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SALL4 gene?

The SALL4 gene is part of a group of genes called the SALL family. These genes provide instructions for making proteins that are involved in the formation of tissues and organs during embryonic development. SALL proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes.

The exact function of the SALL4 protein remains unclear. Based on the functions of similar proteins in other organisms (such as zebrafish and mice), the SALL4 protein appears to play a critical role in the developing limbs. This protein may also be important for the development of nerves that control eye movement and for the formation of the walls (septa) that divide the heart into separate chambers.

Interactant

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