Sequence in raw or FASTA format:
SALL4 spalt-like transcription factor 4 [Homo sapiens (human)]
|Entrez Gene ID||57167|
|Full Name||spalt-like transcription factor 4|
|Synonyms||DRRS, HSAL4, ZNF797, dJ1112F19.1|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). [provided by RefSeq, Jul 2008].|
Duane-radial ray syndrome, 607323 (3); IVIC syndrome, 147750 (3)
|wnt_beta_catenin_pathway||Regulation of Wnt-mediated beta catenin signaling and target gene transcription|
|REACT_200812||Transcriptional regulation of pluripotent stem cells|
|Homo sapiens (human)||SALL4||NP_065169.1|
|Pan troglodytes (chimpanzee)||SALL4||XP_514728.2|
|Macaca mulatta (Rhesus monkey)||SALL4||XP_001093669.1|
|Canis lupus familiaris (dog)||SALL4||XP_543055.2|
|Bos taurus (cattle)||SALL4||NP_001179765.1|
|Mus musculus (house mouse)||Sall4||NP_780512.2|
|Rattus norvegicus (Norway rat)||Sall4||XP_003749680.1|
|Gallus gallus (chicken)||SALL4||NP_001074341.1|
|Danio rerio (zebrafish)||sall4||NP_001074078.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||sall4||NP_001001458.1|
|GO:0000122||negative regulation of transcription from RNA polymerase II promoter||IEA|
|GO:0001833||inner cell mass cell proliferation||IEA|
|GO:0001843||neural tube closure||IEA|
|GO:0003281||ventricular septum development||IEA|
|GO:0019827||stem cell maintenance||IEA|
|GO:0030326||embryonic limb morphogenesis||IEA|
|GO:0045944||positive regulation of transcription from RNA polymerase II promoter||IEA|
|GO:0046872||metal ion binding||IEA|
What is the normal function of the SALL4 gene?
The SALL4 gene is part of a group of genes called the SALL family. These genes provide instructions for making proteins that are involved in the formation of tissues and organs during embryonic development. SALL proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes.
The exact function of the SALL4 protein remains unclear. Based on the functions of similar proteins in other organisms (such as zebrafish and mice), the SALL4 protein appears to play a critical role in the developing limbs. This protein may also be important for the development of nerves that control eye movement and for the formation of the walls (septa) that divide the heart into separate chambers.
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