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PTEN phosphatase and tensin homolog [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000314 Homo sapiens phosphatase and tensin homolog (PTEN), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_006717926 PREDICTED: Homo sapiens phosphatase and tensin homolog (PTEN), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006717927 PREDICTED: Homo sapiens phosphatase and tensin homolog (PTEN), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol PTEN
Entrez Gene ID 5728
Full Name phosphatase and tensin homolog
Synonyms 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q23.3

Summary This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601728

Cowden disease, 158350 (3); Lhermitte-Duclos syndrome, 158350 (3); Bannayan-Riley-Ruvalcaba syndrome, 153480 (3); {Meningioma}, 607174 (3);

mRNA Protein Product Sequence Price Select
NM_000314, 110224474 NP_000305, 73765544 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ORF Sequence $269.00
XM_006717926, 578819652 XP_006717989, 578819653 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 ORF Sequence $400.00
XM_006717927, 578819654 XP_006717990, 578819655 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 ORF Sequence $250.00
KEGG
hsa00562Inositol phosphate metabolism
hsa04115p53 signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04510Focal adhesion
hsa04150mTOR signaling pathway
hsa04530Tight junction
hsa05218Melanoma
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05214Glioma
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa05206MicroRNAs in cancer
hsa04068FoxO signaling pathway
WikiPathways
WP138Androgen receptor signaling pathway
WP1984Integrated Breast Cancer Pathway
WP615Senescence and Autophagy
WP481Insulin Signaling
WP710DNA damage response (only ATM dependent)
WP2377Integrated Pancreatic Cancer Pathway
WP1971Integrated Cancer pathway
WP2261Signaling Pathways in Glioblastoma
WP2038Regulation of Microtubule Cytoskeleton
WP2263Prostate Cancer
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
tcr_pathwayTCR signaling in naive CD4+ T cells
pi3kcipathwayClass I PI3K signaling events
bcr_5pathwayBCR signaling pathway
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pdgfrbpathwayPDGFR-beta signaling pathway
rhoa_pathwayRhoA signaling pathway
BIOCYC
HUMAN_PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
HUMAN_PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
HUMAN_PWY-63683-phosphoinositide degradation
HUMAN_PWY-6371superpathway of inositol phosphate compounds
Reactome
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_11061Signalling by NGF
REACT_12447Negative regulation of the PI3K/AKT network
REACT_12526TCR signaling
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_22258Metabolism of lipids and lipoproteins
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111217Metabolism
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_121175PI Metabolism
REACT_120870Phospholipid metabolism
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150154Inositol phosphate metabolism
REACT_150312Synthesis of IP3 and IP4 in the cytosol
Homo sapiens (human)PTENNP_000305.3
Pan troglodytes (chimpanzee)PTENXP_521544.3
Macaca mulatta (Rhesus monkey)PTENXP_001102542.1
Canis lupus familiaris (dog)PTENNP_001003192.1
Bos taurus (cattle)PTENXP_002698416.1
Mus musculus (house mouse)PtenNP_032986.1
Rattus norvegicus (Norway rat)PtenNP_113794.1
Gallus gallus (chicken)PTENXP_421555.2
Danio rerio (zebrafish)ptenbNP_001001822.1
Drosophila melanogaster (fruit fly)PtenNP_001162933.1
Xenopus (Silurana) tropicalis (western clawed frog)ptenNP_001116943.1
Process
IDNameEvidence
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityTAS
GO:0001525angiogenesisIEA
GO:0001933negative regulation of protein phosphorylationIDA
GO:0002902regulation of B cell apoptotic processIEA
GO:0006470protein dephosphorylationIDA
GO:0006470protein dephosphorylationTAS
GO:0006644phospholipid metabolic processTAS
GO:0006661phosphatidylinositol biosynthetic processTAS
GO:0006915apoptotic processISS
GO:0007092activation of mitotic anaphase-promoting complex activityIDA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007270neuron-neuron synaptic transmissionISS
GO:0007416synapse assemblyISS
GO:0007417central nervous system developmentISS
GO:0007507heart developmentISS
GO:0007568agingIEA
GO:0007584response to nutrientIEA
GO:0007611learning or memoryISS
GO:0007613memoryIEA
GO:0007626locomotory behaviorISS
GO:0008283cell proliferationTAS
GO:0008284positive regulation of cell proliferationISS
GO:0008285negative regulation of cell proliferationIDA
GO:0008285negative regulation of cell proliferationIMP
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009749response to glucoseIEA
GO:0010043response to zinc ionIEA
GO:0010975regulation of neuron projection developmentISS
GO:0014067negative regulation of phosphatidylinositol 3-kinase signalingTAS
GO:0016477cell migrationISS
GO:0021542dentate gyrus developmentISS
GO:0021955central nervous system neuron axonogenesisISS
GO:0030336negative regulation of cell migrationIMP
GO:0031642negative regulation of myelinationIEA
GO:0031647regulation of protein stabilityIMP
GO:0031658negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleIDA
GO:0032286central nervous system myelin maintenanceISS
GO:0032355response to estradiolIEA
GO:0032535regulation of cellular component sizeISS
GO:0033032regulation of myeloid cell apoptotic processIEA
GO:0033198response to ATPIEA
GO:0033555multicellular organismal response to stressISS
GO:0035176social behaviorISS
GO:0035335peptidyl-tyrosine dephosphorylationIDA
GO:0035335peptidyl-tyrosine dephosphorylationIEA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042493response to drugIEA
GO:0042711maternal behaviorIEA
GO:0043065positive regulation of apoptotic processIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0043491protein kinase B signalingISS
GO:0043542endothelial cell migrationIEA
GO:0043647inositol phosphate metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0045471response to ethanolIEA
GO:0045475locomotor rhythmISS
GO:0045792negative regulation of cell sizeISS
GO:0046621negative regulation of organ growthISS
GO:0046685response to arsenic-containing substanceIEA
GO:0046855inositol phosphate dephosphorylationIDA
GO:0046856phosphatidylinositol dephosphorylationIDA
GO:0046856phosphatidylinositol dephosphorylationIMP
GO:0048008platelet-derived growth factor receptor signaling pathwayIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048738cardiac muscle tissue developmentIEA
GO:0048853forebrain morphogenesisISS
GO:0048854brain morphogenesisISS
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0050765negative regulation of phagocytosisIEA
GO:0050771negative regulation of axonogenesisISS
GO:0050821protein stabilizationIDA
GO:0050852T cell receptor signaling pathwayTAS
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIMP
GO:0051895negative regulation of focal adhesion assemblyIMP
GO:0051898negative regulation of protein kinase B signalingIMP
GO:0060024rhythmic synaptic transmissionISS
GO:0060070canonical Wnt signaling pathwayIDA
GO:0060074synapse maturationISS
GO:0060134prepulse inhibitionISS
GO:0060179male mating behaviorIEA
GO:0060291long-term synaptic potentiationIEA
GO:0060292long term synaptic depressionIEA
GO:0060736prostate gland growthIEA
GO:0060997dendritic spine morphogenesisISS
GO:0061002negative regulation of dendritic spine morphogenesisISS
GO:0090071negative regulation of ribosome biogenesisIEA
GO:0090344negative regulation of cell agingIEA
GO:0090394negative regulation of excitatory postsynaptic membrane potentialISS
GO:0097105presynaptic membrane assemblyISS
GO:0097107postsynaptic density assemblyISS
GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDA
GO:2000134negative regulation of G1/S transition of mitotic cell cycleIDA
GO:2000463positive regulation of excitatory postsynaptic membrane potentialISS
GO:2000808negative regulation of synaptic vesicle clusteringISS
GO:2001235positive regulation of apoptotic signaling pathwayIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmTAS
GO:0005739mitochondrionIEA
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0009898cytoplasmic side of plasma membraneIDA
GO:0016605PML bodyIEA
GO:0035749myelin sheath adaxonal regionISS
GO:0042995cell projectionIDA
GO:0043005neuron projectionISS
GO:0043197dendritic spineIEA
GO:0043220Schmidt-Lanterman incisureISS
GO:0045211postsynaptic membraneIEA
Function
IDNameEvidence
GO:0000287magnesium ion bindingIEA
GO:0004438phosphatidylinositol-3-phosphatase activityIDA
GO:0004721phosphoprotein phosphatase activityIDA
GO:0004722protein serine/threonine phosphatase activityIDA
GO:0004725protein tyrosine phosphatase activityIDA
GO:0005161platelet-derived growth factor receptor bindingIEA
GO:0005515protein bindingIPI
GO:0008138protein tyrosine/serine/threonine phosphatase activityIEA
GO:0008289lipid bindingIEA
GO:0010997anaphase-promoting complex bindingIPI
GO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activityIDA
GO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activityTAS
GO:0019899enzyme bindingIPI
GO:0019901protein kinase bindingIEA
GO:0030165PDZ domain bindingIPI
GO:0051717inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activityIDA
GO:0051717inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activityTAS
GO:0051800phosphatidylinositol-3,4-bisphosphate 3-phosphatase activityIDA
GO:0051800phosphatidylinositol-3,4-bisphosphate 3-phosphatase activityTAS
GeneCards PTEN
PDB 2KYL, 4O1V, 1D5R
UniProt F6KD01, F2YHV0, P60484
MIM 601728
HGNC 9588
HPRD 03431

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PTEN gene?

The PTEN gene provides instructions for making a protein that is found in almost all tissues in the body. The protein acts as a tumor suppressor, which means that it helps regulate the cycle of cell division by keeping cells from growing and dividing too rapidly or in an uncontrolled way. The PTEN protein is an enzyme that modifies other proteins and fats (lipids) by removing phosphate groups, which consist of three oxygen atoms and one phosphorus atom. This type of enzyme is called a phosphatase.

The PTEN protein acts as part of a chemical pathway that signals cells to stop dividing and triggers cells to self-destruct through a process called apoptosis. Evidence suggests that the PTEN protein also helps control cell movement (migration), the sticking (adhesion) of cells to surrounding tissues, and the formation of new blood vessels (angiogenesis). Additionally, the protein likely plays a role in maintaining the stability of a cell's genetic information. All of these functions help prevent uncontrolled cell growth that can lead to the formation of tumors.

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