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PTEN phosphatase and tensin homolog [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000314 Homo sapiens phosphatase and tensin homolog (PTEN), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol PTEN
Entrez Gene ID 5728
Full Name phosphatase and tensin homolog
Synonyms 10q23del, BZS, DEC, GLM2, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q23.3

Summary This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601728

Cowden disease, 158350 (3); Lhermitte-Duclos syndrome, 158350 (3); Bannayan-Riley-Ruvalcaba syndrome, 153480 (3); {Meningioma}, 607174 (3);

mRNA Protein Product Sequence Price Select
NM_000314, 110224474 NP_000305, 73765544 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ORF Sequence $269.00
KEGG
hsa04530Tight junction
hsa05161Hepatitis B
hsa04151PI3K-Akt signaling pathway
hsa05218Melanoma
hsa04115p53 signaling pathway
hsa05200Pathways in cancer
hsa00562Inositol phosphate metabolism
hsa04510Focal adhesion
hsa05214Glioma
hsa05213Endometrial cancer
hsa04070Phosphatidylinositol signaling system
hsa05222Small cell lung cancer
hsa05215Prostate cancer
hsa04150mTOR signaling pathway
WikiPathways
WP138Androgen receptor signaling pathway
WP615Senescence and Autophagy
WP2377Integrated Pancreatic Cancer Pathway
WP2261Signaling Pathways in Glioblastoma
WP2256Integrated Pancreatic Cancer Pathway
WP1984Integrated Breast Cancer Pathway
WP710DNA damage response (only ATM dependent)
WP313Signaling of Hepatocyte Growth Factor Receptor
WP481Insulin Signaling
WP1971Integrated Cancer pathway
WP306Focal Adhesion
Pathway Interaction Database
pi3kcipathwayClass I PI3K signaling events
tcr_pathwayTCR signaling in naive CD4+ T cells
p53downstreampathwayDirect p53 effectors
bcr_5pathwayBCR signaling pathway
pdgfrbpathwayPDGFR-beta signaling pathway
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
rhoa_pathwayRhoA signaling pathway
BIOCYC
HUMAN_PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
META_PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
META_PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
HUMAN_PWY-63683-phosphoinositide degradation
META_PWY-63683-phosphoinositide degradation
HUMAN_PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
HUMAN_PWY-6371superpathway of inositol phosphate compounds
Reactome
REACT_115871Signaling by EGFR in Cancer
REACT_9417Signaling by EGFR
REACT_12447Negative regulation of the PI3K/AKT network
REACT_111217Metabolism
REACT_75829PIP3 activates AKT signaling
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_147694DAP12 interactions
REACT_120870Phospholipid metabolism
REACT_6900Immune System
REACT_147814DAP12 signaling
REACT_6802Innate Immune System
REACT_121175PI Metabolism
REACT_111040Signaling by SCF-KIT
REACT_11061Signalling by NGF
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_115961PI3K events in ERBB4 signaling
REACT_12526TCR signaling
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_12464PI3K/AKT activation
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_17025Downstream signal transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_22258Metabolism of lipids and lipoproteins
REACT_120736Signaling by FGFR in disease
REACT_21270PI-3K cascade
REACT_147723PI3K/AKT Signaling in Cancer
REACT_116008PI3K events in ERBB2 signaling
REACT_12555Downstream TCR signaling
REACT_12578GAB1 signalosome
REACT_21272Downstream signaling of activated FGFR
REACT_75774Adaptive Immune System
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
REACT_9470Signaling by FGFR
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_116125Disease
Homo sapiens (human)PTENNP_000305.3
Pan troglodytes (chimpanzee)PTENXP_521544.3
Macaca mulatta (Rhesus monkey)PTENXP_001102542.1
Canis lupus familiaris (dog)PTENNP_001003192.1
Bos taurus (cattle)PTENXP_002698416.1
Mus musculus (house mouse)PtenNP_032986.1
Rattus norvegicus (Norway rat)PtenNP_113794.1
Gallus gallus (chicken)PTENXP_421555.2
Danio rerio (zebrafish)ptenbNP_001001822.1
Drosophila melanogaster (fruit fly)PtenNP_477424.1
GeneCards PTEN
PDB 2KYL, 1D5R
UniProt F6KD01, P60484
MIM 601728
Ensembl ENSG00000171862
HGNC 9588
HPRD 03431

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