PTEN phosphatase and tensin homolog [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	PTEN
Entrez Gene ID	5728
Full Name	phosphatase and tensin homolog
Synonyms	10q23del, BZS, DEC, GLM2, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:10 Map Location:10q23.3
Summary	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq].
Disorder	MIM: 601728 Cowden disease, 158350 (3); Lhermitte-Duclos syndrome, 158350 (3); Bannayan-Riley-Ruvalcaba syndrome, 153480 (3); {Meningioma}, 607174 (3);

mRNA	NM_000314, 110224474
Protein	NP_000305, 73765544
Product	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
RefSeq Status	REVIEWED

KEGG

hsa00562	Inositol phosphate metabolism
hsa05200	Pathways in cancer
hsa04115	p53 signaling pathway
hsa04510	Focal adhesion
hsa05214	Glioma
hsa04070	Phosphatidylinositol signaling system
hsa05213	Endometrial cancer
hsa05222	Small cell lung cancer
hsa05215	Prostate cancer
hsa04530	Tight junction
hsa05218	Melanoma

Pathway Interaction Database

tcr_pathway	TCR signaling in naive CD4+ T cells
pdgfrbpathway	PDGFR-beta signaling pathway
bcr_5pathway	BCR signaling pathway
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
rhoa_pathway	RhoA signaling pathway
p53downstreampathway	Direct p53 effectors
pi3kcipathway	Class I PI3K signaling events

WikiPathways

WP615	Senescence and Autophagy
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP481	Insulin Signaling
WP306	Focal Adhesion
WP138	Androgen Receptor Signaling Pathway

BIOCYC

META_PWY-6368	3-phosphoinositide degradation
META_PWY-6371	superpathway of inositol phosphate compounds
META_PWY-6358	superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
META_PWY-6364	D-myo-inositol (1,3,4)-trisphosphate biosynthesis

Reactome

REACT_6900	Signaling in Immune system
REACT_12464	PI3K/AKT signalling
REACT_12526	TCR signaling
REACT_12555	Downstream TCR signaling
REACT_12056	NGF signalling via TRKA from the plasma membrane
REACT_11061	Signalling by NGF
REACT_12447	Negative regulation of the PI3K/AKT network

Homo sapiens (human)	PTEN	NP_000305.3
Pan troglodytes (chimpanzee)	PTEN	XP_521544.2
Canis lupus familiaris (dog)	PTEN	NP_001003192.1
Bos taurus (cattle)	PTEN	XP_613125.4
Mus musculus (house mouse)	Pten	NP_032986.1
Rattus norvegicus (Norway rat)	Pten	NP_113794.1
Gallus gallus (chicken)	PTEN	XP_421555.1
Danio rerio (zebrafish)	ptenb	NP_001001822.1
Drosophila melanogaster (fruit fly)	Pten	NP_001162933.1

Process

ID	Name	Evidence
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS
GO:0001525	angiogenesis	IEA
GO:0001933	negative regulation of protein phosphorylation	IDA
GO:0002902	regulation of B cell apoptosis	IEA
GO:0006470	protein dephosphorylation	IDA
GO:0006470	protein dephosphorylation	TAS
GO:0006629	lipid metabolic process	IEA
GO:0006917	induction of apoptosis	ISS
GO:0007092	activation of mitotic anaphase-promoting complex activity	IDA
GO:0007417	central nervous system development	ISS
GO:0007507	heart development	ISS
GO:0007568	aging	IEA
GO:0007584	response to nutrient	IEA
GO:0007613	memory	IEA
GO:0008283	cell proliferation	TAS
GO:0008285	negative regulation of cell proliferation	IDA
GO:0008285	negative regulation of cell proliferation	IMP
GO:0009749	response to glucose stimulus	IEA
GO:0010043	response to zinc ion	IEA
GO:0010975	regulation of neuron projection development	ISS
GO:0014070	response to organic cyclic compound	IEA
GO:0016477	cell migration	ISS
GO:0030336	negative regulation of cell migration	IMP
GO:0031647	regulation of protein stability	IMP
GO:0031658	negative regulation of cyclin-dependent protein kinase activity involved in G1/S	IDA
GO:0032355	response to estradiol stimulus	IEA
GO:0033032	regulation of myeloid cell apoptosis	IEA
GO:0033198	response to ATP	IEA
GO:0035335	peptidyl-tyrosine dephosphorylation	IDA
GO:0042493	response to drug	IEA
GO:0043066	negative regulation of apoptosis	IEA
GO:0043542	endothelial cell migration	IEA
GO:0045471	response to ethanol	IEA
GO:0046685	response to arsenic-containing substance	IEA
GO:0046855	inositol phosphate dephosphorylation	IDA
GO:0046856	phosphatidylinositol dephosphorylation	IDA
GO:0048008	platelet-derived growth factor receptor signaling pathway	IEA
GO:0048011	nerve growth factor receptor signaling pathway	TAS
GO:0048015	phosphatidylinositol-mediated signaling	TAS
GO:0048738	cardiac muscle tissue development	IEA
GO:0050680	negative regulation of epithelial cell proliferation	IEA
GO:0050765	negative regulation of phagocytosis	IEA
GO:0050821	protein stabilization	IDA
GO:0050852	T cell receptor signaling pathway	TAS
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IMP
GO:0051895	negative regulation of focal adhesion assembly	IMP
GO:0051898	negative regulation of protein kinase B signaling cascade	IMP
GO:0060070	canonical Wnt receptor signaling pathway	IDA
GO:0060292	long term synaptic depression	IEA
GO:0060736	prostate gland growth	IEA
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	IDA
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	IDA

Component

ID	Name	Evidence
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005737	cytoplasm	TAS
GO:0005739	mitochondrion	IEA
GO:0005829	cytosol	EXP
GO:0005829	cytosol	TAS
GO:0009898	internal side of plasma membrane	IDA
GO:0016605	PML body	IEA
GO:0019717	synaptosome	IEA
GO:0043197	dendritic spine	IEA
GO:0045211	postsynaptic membrane	IEA

Function

ID	Name	Evidence
GO:0000287	magnesium ion binding	IEA
GO:0004438	phosphatidylinositol-3-phosphatase activity	IDA
GO:0004721	phosphoprotein phosphatase activity	IDA
GO:0004722	protein serine/threonine phosphatase activity	IDA
GO:0004725	protein tyrosine phosphatase activity	IDA
GO:0005161	platelet-derived growth factor receptor binding	IEA
GO:0005515	protein binding	IPI
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA
GO:0008289	lipid binding	IEA
GO:0010997	anaphase-promoting complex binding	IPI
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	EXP
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IDA
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	TAS
GO:0016787	hydrolase activity	IEA
GO:0019899	enzyme binding	IPI
GO:0030165	PDZ domain binding	IPI
GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IDA
GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IDA

GeneCards	PTEN
PDB	1D5R
UniProt	P60484
MIM	601728
Ensembl	ENSG00000171862
HGNC	9588
HPRD	03431

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000314	Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.	Full Length	$2507.40
NM_000314	Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.	ORF Sequence	$351.48