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Sequence in raw or FASTA format:

Database:

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PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000963 Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), mRNA. ORF Sequence $526.35
Peptide Services
Antibody Services
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Gene Symbol PTGS2
Entrez Gene ID 5743
Full Name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25.2-q25.3

Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].
Disorder

MIM: 600262

mRNA Protein Product Sequence Price Select
NM_000963, 223941909 NP_000954, 4506265 prostaglandin G/H synthase 2 precursor Full Length $1577.45
ORF Sequence $526.35
KEGG
hsa05200Pathways in cancer
hsa00590Arachidonic acid metabolism
hsa05140Leishmaniasis
hsa05204Chemical carcinogenesis
hsa05222Small cell lung cancer
hsa04370VEGF signaling pathway
hsa04726Serotonergic synapse
hsa04064NF-kappa B signaling pathway
hsa04723Retrograde endocannabinoid signaling
WikiPathways
WP167Eicosanoid Synthesis
WP2256Integrated Pancreatic Cancer Pathway
WP98Prostaglandin Synthesis and Regulation
WP2377Integrated Pancreatic Cancer Pathway
WP15Selenium Pathway
Pathway Interaction Database
s1p_s1p1_pathwayS1P1 pathway
p38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
tcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
cmyb_pathwayC-MYB transcription factor network
BIOCYC
HUMAN_PWY66-374prostanoid biosynthesis
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_147851Arachidonic acid metabolism
Homo sapiens (human)PTGS2NP_000954.1
Pan troglodytes (chimpanzee)PTGS2XP_524999.3
Macaca mulatta (Rhesus monkey)PTGS2XP_001107538.2
Canis lupus familiaris (dog)PTGS2NP_001003354.1
Bos taurus (cattle)PTGS2NP_776870.1
Mus musculus (house mouse)Ptgs2NP_035328.2
Rattus norvegicus (Norway rat)Ptgs2NP_058928.3
Gallus gallus (chicken)PTGS2NP_001161191.1
Danio rerio (zebrafish)ptgs2bNP_001020675.1
GeneCards PTGS2
PDB 1V0X
UniProt P35354
MIM 600262
Ensembl ENSG00000073756
HGNC 9605
HPRD 02599

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
prostaglandin G/H synthase 2
Names
prostaglandin G/H synthase 2
PHS II
PGH synthase 2
cyclooxygenase 2b
prostaglandin H2 synthase 2
NP_000954.1

Interactant

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