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PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27989 NM_000963 Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu27989C NM_000963 Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PTGS2
Entrez Gene ID 5743
Full Name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
General protein information
Preferred Names
prostaglandin G/H synthase 2
Names
prostaglandin G/H synthase 2
PHS II
PGH synthase 2
cyclooxygenase 2b
prostaglandin H2 synthase 2
NP_000954.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25.2-q25.3

Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].
Disorder

MIM: 600262

mRNA Protein Product Sequence Price Select
NM_000963, 574956975 NP_000954, 4506265 prostaglandin G/H synthase 2 precursor ORF Sequence $490.00
KEGG
hsa00590Arachidonic acid metabolism
hsa04370VEGF signaling pathway
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05140Leishmaniasis
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04064NF-kappa B signaling pathway
hsa05204Chemical carcinogenesis
hsa04913Ovarian steroidogenesis
hsa05206MicroRNAs in cancer
hsa04668TNF signaling pathway
hsa04921Oxytocin signaling pathway
WikiPathways
WP15Selenium Pathway
WP98Prostaglandin Synthesis and Regulation
WP167Eicosanoid Synthesis
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
tcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
s1p_s1p1_pathwayS1P1 pathway
p38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
cmyb_pathwayC-MYB transcription factor network
BIOCYC
HUMAN_PWY66-374prostanoid biosynthesis
META_PWY66-393aspirin-triggered lipoxin biosynthesis
META_PWY66-374C20 prostanoid biosynthesis
META_PWY66-394aspirin triggered resolvin E biosynthesis
META_PWY66-395aspirin triggered resolvin D biosynthesis
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_147851Arachidonic acid metabolism
REACT_150422Synthesis of 15-eicosatetraenoic acid derivatives
REACT_150149Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Homo sapiens (human)PTGS2NP_000954.1
Pan troglodytes (chimpanzee)PTGS2XP_524999.3
Macaca mulatta (Rhesus monkey)PTGS2XP_001107538.2
Canis lupus familiaris (dog)PTGS2NP_001003354.1
Bos taurus (cattle)PTGS2NP_776870.1
Mus musculus (house mouse)Ptgs2NP_035328.2
Rattus norvegicus (Norway rat)Ptgs2NP_058928.3
Gallus gallus (chicken)PTGS2NP_001161191.1
Danio rerio (zebrafish)ptgs2bNP_001020675.1
Xenopus (Silurana) tropicalis (western clawed frog)ptgs2NP_001025697.1
Process
IDNameEvidence
GO:0001516prostaglandin biosynthetic processISS
GO:0001516prostaglandin biosynthetic processNAS
GO:0001525angiogenesisIEA
GO:0006693prostaglandin metabolic processTAS
GO:0006928cellular component movementTAS
GO:0006954inflammatory responseIEA
GO:0006979response to oxidative stressIEA
GO:0007566embryo implantationIEA
GO:0007612learningIEA
GO:0007613memoryIEA
GO:0008217regulation of blood pressureISS
GO:0008285negative regulation of cell proliferationIEA
GO:0009750response to fructoseIEA
GO:0010042response to manganese ionIEA
GO:0010226response to lithium ionIEA
GO:0010575positive regulation vascular endothelial growth factor productionISS
GO:0019233sensory perception of painIEA
GO:0019369arachidonic acid metabolic processTAS
GO:0019371cyclooxygenase pathwayIDA
GO:0019371cyclooxygenase pathwayTAS
GO:0019372lipoxygenase pathwayTAS
GO:0030282bone mineralizationIEA
GO:0030728ovulationIEA
GO:0031394positive regulation of prostaglandin biosynthetic processNAS
GO:0031622positive regulation of fever generationISS
GO:0031915positive regulation of synaptic plasticityIEA
GO:0032227negative regulation of synaptic transmission, dopaminergicIEA
GO:0032355response to estradiolIEA
GO:0032496response to lipopolysaccharideIEA
GO:0033280response to vitamin DIEA
GO:0034612response to tumor necrosis factorIEA
GO:0034644cellular response to UVIEA
GO:0035633maintenance of blood-brain barrierIEA
GO:0042346positive regulation of NF-kappaB import into nucleusIEA
GO:0042493response to drugIEA
GO:0042640anagenIEA
GO:0043065positive regulation of apoptotic processIEA
GO:0044281small molecule metabolic processTAS
GO:0045429positive regulation of nitric oxide biosynthetic processISS
GO:0045786negative regulation of cell cycleIEA
GO:0045907positive regulation of vasoconstrictionIEA
GO:0045986negative regulation of smooth muscle contractionIEA
GO:0045987positive regulation of smooth muscle contractionIEA
GO:0046697decidualizationIEA
GO:0048661positive regulation of smooth muscle cell proliferationIEA
GO:0050727regulation of inflammatory responseNAS
GO:0050873brown fat cell differentiationIEA
GO:0051384response to glucocorticoidIEA
GO:0051926negative regulation of calcium ion transportIEA
GO:0051968positive regulation of synaptic transmission, glutamatergicIEA
GO:0055114oxidation-reduction processIEA
GO:0070542response to fatty acidIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0071318cellular response to ATPIEA
GO:0071456cellular response to hypoxiaIEP
GO:0071636positive regulation of transforming growth factor beta productionISS
GO:0090050positive regulation of cell migration involved in sprouting angiogenesisISS
GO:0090271positive regulation of fibroblast growth factor productionISS
GO:0090336positive regulation of brown fat cell differentiationISS
GO:0090362positive regulation of platelet-derived growth factor productionISS
Component
IDNameEvidence
GO:0005634nucleusISS
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISS
GO:0005789endoplasmic reticulum membraneTAS
GO:0043005neuron projectionIDA
GO:0043234protein complexIEA
Function
IDNameEvidence
GO:0004601peroxidase activityNAS
GO:0004666prostaglandin-endoperoxide synthase activityIDA
GO:0008289lipid bindingIEA
GO:0019899enzyme bindingIPI
GO:0020037heme bindingISS
GO:0042803protein homodimerization activityIEA
GO:0046872metal ion bindingIEA
GO:0050473arachidonate 15-lipoxygenase activityTAS
GeneCards PTGS2
PDB 1V0X
UniProt P35354
Vega OTTHUMG00000035473
MIM 600262
Ensembl ENSG00000073756
HGNC 9605
HPRD 02599

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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