CNOT6 CCR4-NOT transcription complex, subunit 6 [Homo sapiens (human)]
| Gene Symbol | CNOT6 |
| Entrez Gene ID | 57472 |
| Full Name | CCR4-NOT transcription complex, subunit 6 |
| Synonyms | CCR4, KIAA1194 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
5 5q35.3 |
| Summary | The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [provided by RefSeq]. |
| Disorder | MIM: 608951 |
| mRNA | NM_015455, 53829366 |
| Protein | NP_056270, 28872863 |
| Product | CCR4-NOT transcription complex subunit 6 |
| RefSeq Status | REVIEWED |
| hsa03018 | RNA degradation |
Reactome
| REACT_20639 | Deadenylation-dependent mRNA decay |
| REACT_21257 | Metabolism of RNA |
| REACT_20605 | Metabolism of mRNA |
| REACT_20514 | Deadenylation of mRNA |
| Homo sapiens (human) | CNOT6 | NP_056270.2 |
| Pan troglodytes (chimpanzee) | CNOT6 | XP_001155177.1 |
| Canis lupus familiaris (dog) | CNOT6 | XP_538584.2 |
| Bos taurus (cattle) | CNOT6 | NP_001094631.1 |
| Mus musculus (house mouse) | Cnot6 | NP_997649.1 |
| Rattus norvegicus (Norway rat) | Cnot6 | NP_001013878.1 |
| Gallus gallus (chicken) | CNOT6 | XP_414612.2 |
| Danio rerio (zebrafish) | cnot6 | NP_997825.1 |
| Drosophila melanogaster (fruit fly) | twin | NP_732965.1 |
| Caenorhabditis elegans | ccr-4 | NP_502355.2 |
| ID | Name | Evidence |
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS |
| GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0016070 | RNA metabolic process | TAS |
| GO:0016071 | mRNA metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | TAS |
Function
| ID | Name | Evidence |
| GO:0003723 | RNA binding | IEA |
| GO:0004527 | exonuclease activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0016787 | hydrolase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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