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ARID1B AT rich interactive domain 1B (SWI1-like) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_017519 Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_020732 Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005267069 PREDICTED: Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006715523 PREDICTED: Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006715524 PREDICTED: Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006715525 PREDICTED: Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006715526 PREDICTED: Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006715527 PREDICTED: Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Related Services

Gene Symbol ARID1B
Entrez Gene ID 57492
Full Name AT rich interactive domain 1B (SWI1-like)
Synonyms 6A3-5, BAF250B, BRIGHT, DAN15, ELD/OSA1, MRD12, OSA2, P250R
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q25.1

Summary This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2012].
Disorder

MIM: 614556

mRNA Protein Product Sequence Price Select
NM_017519, 297139702 NP_059989, 297139703 AT-rich interactive domain-containing protein 1B isoform 1 ORF Sequence $3500.00
NM_020732, 297207098 NP_065783, 297207099 AT-rich interactive domain-containing protein 1B isoform 2 ORF Sequence $3500.00
XM_005267069, 578812871 XP_005267126, 530383904 AT-rich interactive domain-containing protein 1B isoform X1 ORF Sequence $3500.00
XM_006715523, 578812863 XP_006715586, 578812864 AT-rich interactive domain-containing protein 1B isoform X2 ORF Sequence $3500.00
XM_006715524, 578812865 XP_006715587, 578812866 AT-rich interactive domain-containing protein 1B isoform X3 ORF Sequence $3500.00
XM_006715525, 578812867 XP_006715588, 578812868 AT-rich interactive domain-containing protein 1B isoform X4 ORF Sequence $3500.00
XM_006715526, 578812869 XP_006715589, 578812870 AT-rich interactive domain-containing protein 1B isoform X5 ORF Sequence $3500.00
XM_006715527, 578812872 XP_006715590, 578812873 AT-rich interactive domain-containing protein 1B isoform X6 ORF Sequence $3500.00
WikiPathways
WP2263Prostate Cancer
Homo sapiens (human)ARID1BNP_065783.3
Macaca mulatta (Rhesus monkey)ARID1BXP_001096831.2
Canis lupus familiaris (dog)ARID1BXP_005615750.1
Bos taurus (cattle)ARID1BXP_002690406.3
Mus musculus (house mouse)Arid1bNP_001078824.1
Rattus norvegicus (Norway rat)Arid1bXP_006227967.1
Gallus gallus (chicken)ARID1BXP_001232096.3
Danio rerio (zebrafish)arid1bXP_698079.4
Xenopus (Silurana) tropicalis (western clawed frog)arid1bXP_004914686.1
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0007399nervous system developmentIEA
GO:0048096chromatin-mediated maintenance of transcriptionNAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0016514SWI/SNF complexIDA
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0003713transcription coactivator activityNAS
GO:0005515protein bindingIPI
GeneCards ARID1B
UniProt Q8NFD5
Vega OTTHUMG00000015890
MIM 614556
Ensembl ENSG00000049618
HGNC 18040
HPRD 10660

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ARID1B gene?

The ARID1B gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.

Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells. The ARID1B protein and other SWI/SNF subunits are thought to act as tumor suppressors, which keep cells from growing and dividing too rapidly or in an uncontrolled way.

The ARID1B subunit is able to attach (bind) to DNA and is thought to help target SWI/SNF complexes to the chromatin location that needs to be remodeled.

Interactant

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