Sequence in raw or FASTA format:
ARID1B AT rich interactive domain 1B (SWI1-like) [Homo sapiens (human)]
|Entrez Gene ID||57492|
|Full Name||AT rich interactive domain 1B (SWI1-like)|
|Synonyms||6A3-5, BAF250B, BRIGHT, DAN15, ELD/OSA1, MRD12, OSA2, P250R|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2012].|
|Homo sapiens (human)||ARID1B||NP_065783.3|
|Macaca mulatta (Rhesus monkey)||ARID1B||XP_001096831.2|
|Canis lupus familiaris (dog)||ARID1B||XP_005615750.1|
|Bos taurus (cattle)||ARID1B||XP_002690406.3|
|Mus musculus (house mouse)||Arid1b||NP_001078824.1|
|Rattus norvegicus (Norway rat)||Arid1b||XP_006227967.1|
|Gallus gallus (chicken)||ARID1B||XP_001232096.3|
|Danio rerio (zebrafish)||arid1b||XP_698079.4|
|Xenopus (Silurana) tropicalis (western clawed frog)||arid1b||XP_004914686.1|
|GO:0007399||nervous system development||IEA|
|GO:0048096||chromatin-mediated maintenance of transcription||NAS|
|GO:0003713||transcription coactivator activity||NAS|
What is the normal function of the ARID1B gene?
The ARID1B gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.
Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells. The ARID1B protein and other SWI/SNF subunits are thought to act as tumor suppressors, which keep cells from growing and dividing too rapidly or in an uncontrolled way.
The ARID1B subunit is able to attach (bind) to DNA and is thought to help target SWI/SNF complexes to the chromatin location that needs to be remodeled.
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.