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PTPN11 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. ORF Sequence $516.78
Peptide Services
Antibody Services
Protein Services
NM_080601 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 2, mRNA. ORF Sequence $401.07
Peptide Services
Antibody Services
Protein Services


Gene Symbol PTPN11
Entrez Gene ID 5781
Full Name protein tyrosine phosphatase, non-receptor type 11
Synonyms BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24

Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
Disorder

MIM: 176876

Noonan syndrome 1, 163950 (3); LEOPARD syndrome 1, 151100 (3);

mRNA Protein Product Sequence Price Select
NM_002834, 33356176 NP_002825, 33356177 tyrosine-protein phosphatase non-receptor type 11 isoform 1 Full Length $2835.00
ORF Sequence $516.78
NM_080601, 18375643 NP_542168, 18375644 tyrosine-protein phosphatase non-receptor type 11 isoform 2 Full Length $600.01
ORF Sequence $401.07
KEGG
hsa04630Jak-STAT signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04920Adipocytokine signaling pathway
hsa05168Herpes simplex infection
hsa04722Neurotrophin signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05211Renal cell carcinoma
hsa05220Chronic myeloid leukemia
hsa05120Epithelial cell signaling in Helicobacter pylori infection
Pathway Interaction Database
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
avb3_integrin_pathwayIntegrins in angiogenesis
igf1_pathwayIGF1 pathway
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
il6_7pathwayIL6-mediated signaling events
ifngpathwayIFN-gamma pathway
il2_pi3kpathwayIL2 signaling events mediated by PI3K
ret_pathwaySignaling events regulated by Ret tyrosine kinase
fgf_pathwayFGF signaling pathway
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
tcr_pathwayTCR signaling in naive CD4+ T cells
fcer1pathwayFc-epsilon receptor I signaling in mast cells
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
vegfr1_pathwayVEGFR1 specific signals
erbb2erbb3pathwayErbB2/ErbB3 signaling events
il2_stat5pathwayIL2 signaling events mediated by STAT5
il2_1pathwayIL2-mediated signaling events
pdgfrbpathwayPDGFR-beta signaling pathway
epopathwayEPO signaling pathway
cxcr4_pathwayCXCR4-mediated signaling events
insulin_pathwayInsulin Pathway
WikiPathways
WP286IL-3 Signaling Pathway
WP2037Prolactin Signaling Pathway
WP364IL-6 Signaling Pathway
WP22IL-9 Signaling Pathway
WP313Signaling of Hepatocyte Growth Factor Receptor
WP23B Cell Receptor Signaling Pathway
WP2374Oncostatin M Signaling Pathway
WP2332Interleukin-11 Signaling Pathway
WP437EGFR1 Signaling Pathway
WP481Insulin Signaling
WP231TNF-alpha/NF-kB Signaling Pathway
WP2253pilocytic astrocytoma
WP1591Heart Development
WP2034Leptin signaling pathway
WP619Type II interferon signaling (IFNG)
WP127IL-5 Signaling Pathway
WP69TCR Signaling Pathway
WP395IL-4 signaling Pathway
WP304Kit Receptor Signaling Pathway
WP49IL-2 Signaling Pathway
WP2203TSLP Signaling Pathway
Reactome
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_12578GAB1 signalosome
REACT_147723PI3K/AKT Signaling in Cancer
REACT_498Signaling by Insulin receptor
REACT_25078Interferon gamma signaling
REACT_27307Interleukin-6 signaling
REACT_111045Developmental Biology
REACT_120736Signaling by FGFR in disease
REACT_23916Signal regulatory protein (SIRP) family interactions
REACT_111102Signal Transduction
REACT_21270PI-3K cascade
REACT_17025Downstream signal transduction
REACT_9470Signaling by FGFR
REACT_147814DAP12 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_12621Tie2 Signaling
REACT_111080Spry regulation of FGF signaling
REACT_147694DAP12 interactions
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_6900Immune System
REACT_115596Signaling by ERBB4
REACT_12051Cell surface interactions at the vascular wall
REACT_115871Signaling by EGFR in Cancer
REACT_75829PIP3 activates AKT signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75790Cytokine Signaling in Immune system
REACT_111040Signaling by SCF-KIT
REACT_23879Platelet sensitization by LDL
REACT_1195Insulin receptor signalling cascade
REACT_11061Signalling by NGF
REACT_604Hemostasis
REACT_9417Signaling by EGFR
REACT_19324PD-1 signaling
REACT_24980Regulation of IFNG signaling
REACT_976PI3K Cascade
REACT_6802Innate Immune System
REACT_19405CTLA4 inhibitory signaling
REACT_25162Interferon alpha/beta signaling
REACT_116125Disease
REACT_115755Signaling by ERBB2
REACT_111155Cell-Cell communication
REACT_116022Nuclear signaling by ERBB4
REACT_19344Costimulation by the CD28 family
REACT_116008PI3K events in ERBB2 signaling
REACT_111184Negative regulation of FGFR signaling
REACT_12519PECAM1 interactions
REACT_21272Downstream signaling of activated FGFR
REACT_75774Adaptive Immune System
REACT_16888Signaling by PDGF
REACT_21247FRS2-mediated cascade
REACT_18266Axon guidance
REACT_762IRS-related events
REACT_332IRS-mediated signalling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_22237Netrin-1 signaling
REACT_22384Netrin mediated repulsion signals
REACT_22232Signaling by Interleukins
REACT_25216Regulation of IFNA signaling
REACT_115697Prolactin receptor signaling
REACT_12464PI3K/AKT activation
REACT_25229Interferon Signaling
REACT_23876Platelet homeostasis
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
Homo sapiens (human)PTPN11NP_002825.3
Pan troglodytes (chimpanzee)PTPN11XP_001164580.1
Macaca mulatta (Rhesus monkey)PTPN11XP_001110117.1
Canis lupus familiaris (dog)PTPN11XP_534686.4
Bos taurus (cattle)PTPN11XP_002694636.2
Mus musculus (house mouse)Ptpn11NP_035332.1
Rattus norvegicus (Norway rat)Ptpn11NP_037220.1
Gallus gallus (chicken)PTPN11NP_990299.1
Danio rerio (zebrafish)ptpn11aNP_956140.1
Drosophila melanogaster (fruit fly)cswNP_477130.1
Caenorhabditis elegansptp-2NP_495184.1
GeneCards PTPN11
PDB 3TL0, 3TKZ, 3B7O, 4DGP, 3MOW, 4DGX, 3O5X, 2SHP
UniProt Q06124
MIM 176876
Ensembl ENSG00000179295
HGNC 9644
HPRD 01470

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
tyrosine-protein phosphatase non-receptor type 11
PTP-2C
protein-tyrosine phosphatase 1D
protein-tyrosine phosphatase 2C
NP_002825.3
NP_542168.1

Interactant

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