PTPN11 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens (human)]
| Gene Symbol | PTPN11 |
| Entrez Gene ID | 5781 |
| Full Name | protein tyrosine phosphatase, non-receptor type 11 |
| Synonyms | BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12q24 |
| Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]. |
| Disorder | MIM: 176876 Noonan syndrome 1, 163950 (3); LEOPARD syndrome 1, 151100 (3); |
| mRNA | NM_002834, 33356176 |
| Protein | NP_002825, 33356177 |
| Product | tyrosine-protein phosphatase non-receptor type 11 |
| RefSeq Status | REVIEWED |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
| hsa05220 | Chronic myeloid leukemia |
| hsa05211 | Renal cell carcinoma |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04920 | Adipocytokine signaling pathway |
Pathway Interaction Database
| igf1_pathway | IGF1 pathway |
| erbb1_receptor_proximal_pathway | EGF receptor (ErbB1) signaling pathway |
| il6_7pathway | IL6-mediated signaling events |
| trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| fgf_pathway | FGF signaling pathway |
| tcr_pathway | TCR signaling in naive CD4+ T cells |
| fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| vegfr1_pathway | VEGFR1 specific signals |
| erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| il2_1pathway | IL2-mediated signaling events |
| pdgfrbpathway | PDGFR-beta signaling pathway |
| epopathway | EPO signaling pathway |
| cxcr4_pathway | CXCR4-mediated signaling events |
| insulin_pathway | Insulin Pathway |
| il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| ifngpathway | IFN-gamma pathway |
| kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| avb3_integrin_pathway | Integrins in angiogenesis |
| vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
WikiPathways
| WP364 | IL-6 Signaling Pathway |
| WP481 | Insulin Signaling |
| WP1591 | Heart Development |
| WP23 | B Cell Receptor Signaling Pathway |
| WP619 | Type II interferon signaling (IFNG) |
| WP437 | EGFR1 Signaling Pathway |
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
| WP127 | IL-5 Signaling Pathway |
| WP69 | T Cell Receptor Signaling Pathway |
| WP395 | IL-4 signaling Pathway |
| WP304 | Kit Receptor Signaling Pathway |
| WP49 | IL-2 Signaling Pathway |
| WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| WP286 | IL-3 Signaling Pathway |
| WP22 | IL-9 Signaling Pathway |
Reactome
| REACT_20 | Formation of Platelet plug |
| REACT_12051 | Cell surface interactions at the vascular wall |
| REACT_25162 | Interferon alpha/beta signaling |
| REACT_23916 | Signal regulatory protein (SIRP) family interactions |
| REACT_19344 | Costimulation by the CD28 family |
| REACT_17025 | Down-stream signal transduction |
| REACT_12519 | PECAM1 interactions |
| REACT_20676 | Cell junction organization |
| REACT_604 | Hemostasis |
| REACT_24980 | Regulation of IFNG signaling |
| REACT_976 | PI3K Cascade |
| REACT_9417 | Signaling by EGFR |
| REACT_1195 | Insulin receptor signalling cascade |
| REACT_19324 | PD-1 signaling |
| REACT_16888 | Signaling by PDGF |
| REACT_21272 | Downstream signaling of activated FGFR |
| REACT_19405 | CTLA4 inhibitory signaling |
| REACT_21247 | FRS2-mediated cascade |
| REACT_18266 | Axon guidance |
| REACT_762 | IRS-related events |
| REACT_332 | IRS-mediated signalling |
| REACT_23837 | Interleukin-3, 5 and GM-CSF signaling |
| REACT_22237 | Netrin-1 signaling |
| REACT_22384 | Netrin mediated repulsion signals |
| REACT_25216 | Regulation of IFNA signaling |
| REACT_22232 | Signaling by Interleukins |
| REACT_25229 | Interferon Signaling |
| REACT_23876 | Platelet homeostasis |
| REACT_12621 | Tie2 Signaling |
| REACT_12578 | Gab1 signalosome |
| REACT_6900 | Signaling in Immune system |
| REACT_498 | Signaling by Insulin receptor |
| REACT_25078 | Interferon gamma signaling |
| REACT_23853 | Interactions of the immunoglobulin superfamily (IgSF) member proteins |
| REACT_21270 | PI-3K cascade |
| REACT_9470 | Signaling by FGFR |
| REACT_798 | Platelet Activation |
| REACT_23879 | Platelet sensitization by LDL |
| Homo sapiens (human) | PTPN11 | NP_002825.3 |
| Pan troglodytes (chimpanzee) | PTPN11 | XP_522535.2 |
| Pan troglodytes (chimpanzee) | PTPN11 | XP_001164580.1 |
| Canis lupus familiaris (dog) | PTPN11 | XP_534686.2 |
| Bos taurus (cattle) | PTPN11 | XP_613041.3 |
| Mus musculus (house mouse) | Ptpn11 | NP_035332.1 |
| Rattus norvegicus (Norway rat) | Ptpn11 | NP_037220.1 |
| Gallus gallus (chicken) | PTPN11 | NP_990299.1 |
| Danio rerio (zebrafish) | ptpn11a | NP_956140.1 |
| Danio rerio (zebrafish) | LOC100330785 | XP_002663515.1 |
| Drosophila melanogaster (fruit fly) | csw | NP_477130.1 |
| Caenorhabditis elegans | ptp-2 | NP_495184.1 |
| ID | Name | Evidence |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS |
| GO:0007411 | axon guidance | TAS |
| GO:0007596 | blood coagulation | TAS |
| GO:0008286 | insulin receptor signaling pathway | TAS |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS |
| GO:0019221 | cytokine-mediated signaling pathway | TAS |
| GO:0030168 | platelet activation | TAS |
| GO:0031295 | T cell costimulation | TAS |
| GO:0033628 | regulation of cell adhesion mediated by integrin | IMP |
| GO:0034329 | cell junction assembly | TAS |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IMP |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | TAS |
| GO:0048013 | ephrin receptor signaling pathway | IDA |
| GO:0050900 | leukocyte migration | TAS |
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS |
| GO:0060334 | regulation of interferon-gamma-mediated signaling pathway | TAS |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS |
| GO:0060338 | regulation of type I interferon-mediated signaling pathway | TAS |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IDA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
Function
| ID | Name | Evidence |
| GO:0004725 | protein tyrosine phosphatase activity | TAS |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity | EXP |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity | IMP |
| GO:0005515 | protein binding | IPI |
| GO:0016787 | hydrolase activity | IEA |
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