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PTPN11 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24957 NM_080601 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25096 NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu46740 XM_006719526 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu46741 XM_006719527 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu24957C NM_080601 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu25096C NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu46740C XM_006719526 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu46741C XM_006719527 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

*Business Day

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Gene Symbol PTPN11
Entrez Gene ID 5781
Full Name protein tyrosine phosphatase, non-receptor type 11
Synonyms BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
General protein information
Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
tyrosine-protein phosphatase non-receptor type 11
PTP-2C
protein-tyrosine phosphatase 1D
protein-tyrosine phosphatase 2C
NP_002825.3
NP_542168.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24

Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
Disorder

MIM: 176876

Noonan syndrome 1, 163950 (3); LEOPARD syndrome 1, 151100 (3);

mRNA Protein Product Sequence Price Select
NM_002834, 33356176 NP_002825, 33356177 tyrosine-protein phosphatase non-receptor type 11 isoform 1 ORF Sequence $700.00
NM_080601, 18375643 NP_542168, 18375644 tyrosine-protein phosphatase non-receptor type 11 isoform 2 ORF Sequence $550.00
XM_006719526, 578824044 XP_006719589, 578824045 tyrosine-protein phosphatase non-receptor type 11 isoform X1 ORF Sequence $700.00
XM_006719527, 578824046 XP_006719590, 578824047 tyrosine-protein phosphatase non-receptor type 11 isoform X2 ORF Sequence $550.00
KEGG
hsa04650Natural killer cell mediated cytotoxicity
hsa04630Jak-STAT signaling pathway
hsa05211Renal cell carcinoma
hsa04920Adipocytokine signaling pathway
hsa04670Leukocyte transendothelial migration
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05220Chronic myeloid leukemia
hsa04722Neurotrophin signaling pathway
hsa05168Herpes simplex infection
hsa05205Proteoglycans in cancer
hsa04014Ras signaling pathway
WikiPathways
WP437EGFR1 Signaling Pathway
WP127IL-5 Signaling Pathway
WP395IL-4 signaling Pathway
WP1591Heart Development
WP304Kit Receptor Signaling Pathway
WP481Insulin Signaling
WP286IL-3 Signaling Pathway
WP22IL-9 Signaling Pathway
WP49IL-2 Signaling pathway
WP619Type II interferon signaling (IFNG)
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP364IL-6 Signaling Pathway
WP2253pilocytic astrocytoma
WP2332Interleukin-11 Signaling Pathway
WP2374Oncostatin M Signaling Pathway
WP2380BDNF signaling pathway
WP2034Leptin signaling pathway
WP2037Prolactin Signaling Pathway
WP2203TSLP Signaling Pathway
WP2263Prostate Cancer
WP585Interferon type I
Pathway Interaction Database
il6_7pathwayIL6-mediated signaling events
cxcr4_pathwayCXCR4-mediated signaling events
vegfr1_pathwayVEGFR1 specific signals
il2_pi3kpathwayIL2 signaling events mediated by PI3K
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
avb3_integrin_pathwayIntegrins in angiogenesis
il2_1pathwayIL2-mediated signaling events
erbb2erbb3pathwayErbB2/ErbB3 signaling events
tcr_pathwayTCR signaling in naive CD4+ T cells
ret_pathwaySignaling events regulated by Ret tyrosine kinase
fgf_pathwayFGF signaling pathway
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
igf1_pathwayIGF1 pathway
il2_stat5pathwayIL2 signaling events mediated by STAT5
insulin_pathwayInsulin Pathway
ifngpathwayIFN-gamma pathway
fcer1pathwayFc-epsilon receptor I signaling in mast cells
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pdgfrbpathwayPDGFR-beta signaling pathway
epopathwayEPO signaling pathway
Reactome
REACT_18266Axon guidance
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_19324PD-1 signaling
REACT_604Hemostasis
REACT_12621Tie2 Signaling
REACT_12519PECAM1 interactions
REACT_12051Cell surface interactions at the vascular wall
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6966Toll-Like Receptors Cascades
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6809MyD88-independent cascade
REACT_17025Downstream signal transduction
REACT_6890Activated TLR4 signalling
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_1195Insulin receptor signalling cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_11061Signalling by NGF
REACT_22232Signaling by Interleukins
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_21247FRS2-mediated cascade
REACT_22384Netrin mediated repulsion signals
REACT_22237Netrin-1 signaling
REACT_27307Interleukin-6 signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_75829PIP3 activates AKT signaling
REACT_25229Interferon Signaling
REACT_25162Interferon alpha/beta signaling
REACT_23879Platelet sensitization by LDL
REACT_25216Regulation of IFNA signaling
REACT_25148Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23916Signal regulatory protein (SIRP) family interactions
REACT_25078Interferon gamma signaling
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_23876Platelet homeostasis
REACT_24980Regulation of IFNG signaling
REACT_111080Spry regulation of FGF signaling
REACT_111045Developmental Biology
REACT_111184Negative regulation of FGFR signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_111155Cell-Cell communication
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115697Prolactin receptor signaling
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_116022Nuclear signaling by ERBB4
REACT_116008PI3K events in ERBB2 signaling
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
REACT_169118Signaling by Leptin
Homo sapiens (human)PTPN11NP_002825.3
Pan troglodytes (chimpanzee)PTPN11XP_522535.3
Macaca mulatta (Rhesus monkey)PTPN11XP_001110117.1
Canis lupus familiaris (dog)PTPN11XP_005636307.1
Bos taurus (cattle)PTPN11XP_002694636.2
Mus musculus (house mouse)Ptpn11NP_035332.1
Rattus norvegicus (Norway rat)Ptpn11NP_001171064.1
Gallus gallus (chicken)PTPN11NP_990299.1
Danio rerio (zebrafish)ptpn11aNP_956140.1
Drosophila melanogaster (fruit fly)cswNP_001259174.1
Process
IDNameEvidence
GO:0000077DNA damage checkpointIEA
GO:0000187activation of MAPK activityIEA
GO:0006641triglyceride metabolic processIEA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007411axon guidanceTAS
GO:0007420brain developmentIMP
GO:0007507heart developmentIMP
GO:0007596blood coagulationTAS
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009755hormone-mediated signaling pathwayIEA
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0031295T cell costimulationTAS
GO:0033628regulation of cell adhesion mediated by integrinIMP
GO:0035265organ growthIEA
GO:0035335peptidyl-tyrosine dephosphorylationIDA
GO:0035335peptidyl-tyrosine dephosphorylationIMP
GO:0036302atrioventricular canal developmentIMP
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0038127ERBB signaling pathwayIDA
GO:0040014regulation of multicellular organism growthIEA
GO:0042445hormone metabolic processIEA
GO:0042593glucose homeostasisIEA
GO:0045087innate immune responseTAS
GO:0046676negative regulation of insulin secretionIEA
GO:0046825regulation of protein export from nucleusIEA
GO:0046887positive regulation of hormone secretionIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048013ephrin receptor signaling pathwayIDA
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048609multicellular organismal reproductive processIEA
GO:0048806genitalia developmentIMP
GO:0048839inner ear developmentIMP
GO:0050900leukocyte migrationTAS
GO:0051463negative regulation of cortisol secretionIEA
GO:0060125negative regulation of growth hormone secretionIEA
GO:0060325face morphogenesisIMP
GO:0060333interferon-gamma-mediated signaling pathwayTAS
GO:0060334regulation of interferon-gamma-mediated signaling pathwayTAS
GO:0060337type I interferon signaling pathwayTAS
GO:0060338regulation of type I interferon-mediated signaling pathwayTAS
GO:2001275positive regulation of glucose import in response to insulin stimulusIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIEA
GO:0005829cytosolTAS
GO:0043234protein complexIEA
Function
IDNameEvidence
GO:0004721phosphoprotein phosphatase activityIDA
GO:0004725protein tyrosine phosphatase activityIDA
GO:0004725protein tyrosine phosphatase activityTAS
GO:0004726non-membrane spanning protein tyrosine phosphatase activityIMP
GO:0004726non-membrane spanning protein tyrosine phosphatase activityTAS
GO:0005070SH3/SH2 adaptor activityIDA
GO:0005158insulin receptor bindingIPI
GO:0005515protein bindingIPI
GO:0019904protein domain specific bindingIEA
GO:0030971receptor tyrosine kinase bindingIEA
GO:0031748D1 dopamine receptor bindingIEA
GO:0043274phospholipase bindingIEA
GO:0043560insulin receptor substrate bindingIEA
GO:0051428peptide hormone receptor bindingIEA
GeneCards PTPN11
UniProt Q06124
Vega OTTHUMG00000134334
MIM 176876
Ensembl ENSG00000179295
HGNC 9644
HPRD 01470

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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