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Sequence in raw or FASTA format:

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RAD51 RAD51 homolog (S. cerevisiae) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001164269 Homo sapiens RAD51 homolog (S. cerevisiae) (RAD51), transcript variant 4, mRNA. ORF Sequence $296.67
Peptide Services
Antibody Services
Protein Services
NM_001164270 Homo sapiens RAD51 homolog (S. cerevisiae) (RAD51), transcript variant 3, mRNA. ORF Sequence $244.47
Peptide Services
Antibody Services
Protein Services
NM_002875 Homo sapiens RAD51 homolog (S. cerevisiae) (RAD51), transcript variant 1, mRNA. ORF Sequence $295.80
Peptide Services
Antibody Services
Protein Services
NM_133487 Homo sapiens RAD51 homolog (S. cerevisiae) (RAD51), transcript variant 2, mRNA. ORF Sequence $296.67
Peptide Services
Antibody Services
Protein Services


Gene Symbol RAD51
Entrez Gene ID 5888
Full Name RAD51 homolog (S. cerevisiae)
Synonyms BRCC5, HRAD51, HsRad51, HsT16930, RAD51A, RECA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q15.1

Summary The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Disorder

MIM: 179617

{Breast cancer, susceptibility to}, 114480 (3)

mRNA Protein Product Sequence Price Select
NM_001164269, 256017142 NP_001157741, 256017143 DNA repair protein RAD51 homolog 1 isoform 2 Full Length $622.63
ORF Sequence $296.67
NM_001164270, 256017144 NP_001157742, 256017145 DNA repair protein RAD51 homolog 1 isoform 3 Full Length $631.33
ORF Sequence $244.47
NM_002875, 256017139 NP_002866, 19924133 DNA repair protein RAD51 homolog 1 isoform 1 Full Length $666.71
ORF Sequence $295.80
NM_133487, 256017140 NP_597994, 256017141 DNA repair protein RAD51 homolog 1 isoform 2 Full Length $667.58
ORF Sequence $296.67
KEGG
hsa05212Pancreatic cancer
hsa03440Homologous recombination
hsa05200Pathways in cancer
hsa03460Fanconi anemia pathway
WikiPathways
WP1984Integrated Breast Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP707DNA damage response
WP186Homologous recombination
WP2256Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
bard1pathwayBARD1 signaling events
Reactome
REACT_1874Homologous Recombination Repair
REACT_408Presynaptic phase of homologous DNA pairing and strand exchange
REACT_2141Assembly of the RAD51-ssDNA nucleoprotein complex
REACT_111183Meiosis
REACT_216DNA Repair
REACT_1587Homologous recombination repair of replication-independent double-strand breaks
REACT_27271Meiotic Recombination
REACT_2054Double-Strand Break Repair
REACT_1763Homologous DNA pairing and strand exchange
Homo sapiens (human)RAD51NP_002866.2
Pan troglodytes (chimpanzee)RAD51XP_001144621.1
Macaca mulatta (Rhesus monkey)LOC708579XP_001097058.1
Canis lupus familiaris (dog)RAD51NP_001003043.1
Bos taurus (cattle)RAD51NP_001039644.1
Mus musculus (house mouse)Rad51NP_035364.1
Rattus norvegicus (Norway rat)Rad51NP_001102674.1
Gallus gallus (chicken)RAD51NP_990504.1
Danio rerio (zebrafish)rad51NP_998371.1
Drosophila melanogaster (fruit fly)spn-ANP_524583.1
Caenorhabditis elegansrad-51NP_001023465.1
Arabidopsis thaliana (thale cress)RAD51NP_568402.1
GeneCards RAD51
PDB 1N0W, 1B22
UniProt Q06609
MIM 179617
Ensembl ENSG00000051180
HGNC 9817
HPRD 01557

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
DNA repair protein RAD51 homolog 1
Names
DNA repair protein RAD51 homolog 1
RAD51 homolog A
RecA-like protein
recombination protein A
RecA, E. coli, homolog of
BRCA1/BRCA2-containing complex, subunit 5

Interactant

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