• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


RAD51 RAD51 recombinase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001164269 Homo sapiens RAD51 recombinase (RAD51), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001164270 Homo sapiens RAD51 recombinase (RAD51), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_002875 Homo sapiens RAD51 recombinase (RAD51), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_133487 Homo sapiens RAD51 recombinase (RAD51), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006720626 PREDICTED: Homo sapiens RAD51 recombinase (RAD51), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol RAD51
Entrez Gene ID 5888
Full Name RAD51 recombinase
Synonyms BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
General protein information
Preferred Names
DNA repair protein RAD51 homolog 1
Names
DNA repair protein RAD51 homolog 1
RAD51 homolog A
RecA-like protein
recombination protein A
RecA, E. coli, homolog of
BRCA1/BRCA2-containing complex, subunit 5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q15.1

Summary The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Disorder

MIM: 179617

{Breast cancer, susceptibility to}, 114480 (3)

mRNA Protein Product Sequence Price Select
NM_001164269, 256017142 NP_001157741, 256017143 DNA repair protein RAD51 homolog 1 isoform 2 ORF Sequence $400.00
NM_001164270, 256017144 NP_001157742, 256017145 DNA repair protein RAD51 homolog 1 isoform 3 ORF Sequence $300.00
NM_002875, 256017139 NP_002866, 19924133 DNA repair protein RAD51 homolog 1 isoform 1 ORF Sequence $400.00
NM_133487, 256017140 NP_597994, 256017141 DNA repair protein RAD51 homolog 1 isoform 2 ORF Sequence $400.00
XM_006720626, 578827255 XP_006720689, 578827256 DNA repair protein RAD51 homolog 1 isoform X1 ORF Sequence $400.00
KEGG
hsa03440Homologous recombination
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
hsa03460Fanconi anemia pathway
WikiPathways
WP707DNA damage response
WP1984Integrated Breast Cancer Pathway
WP186Homologous recombination
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
bard1pathwayBARD1 signaling events
Reactome
REACT_216DNA Repair
REACT_1587Homologous recombination repair of replication-independent double-strand breaks
REACT_1763Homologous DNA pairing and strand exchange
REACT_408Presynaptic phase of homologous DNA pairing and strand exchange
REACT_2141Assembly of the RAD51-ssDNA nucleoprotein complex
REACT_2054Double-Strand Break Repair
REACT_1874Homologous Recombination Repair
REACT_27271Meiotic recombination
REACT_111183Meiosis
REACT_115566Cell Cycle
Homo sapiens (human)RAD51NP_002866.2
Pan troglodytes (chimpanzee)RAD51XP_001144621.1
Macaca mulatta (Rhesus monkey)LOC708579XP_001097058.1
Canis lupus familiaris (dog)RAD51NP_001003043.1
Bos taurus (cattle)RAD51NP_001039644.1
Mus musculus (house mouse)Rad51NP_035364.1
Rattus norvegicus (Norway rat)Rad51NP_001102674.1
Gallus gallus (chicken)RAD51NP_990504.1
Danio rerio (zebrafish)rad51NP_998371.2
Drosophila melanogaster (fruit fly)spn-ANP_524583.1
Caenorhabditis elegansrad-51NP_001023465.1
Arabidopsis thaliana (thale cress)RAD51NP_568402.1
Xenopus (Silurana) tropicalis (western clawed frog)rad51NP_001016393.1
Process
IDNameEvidence
GO:0000724double-strand break repair via homologous recombinationIDA
GO:0000724double-strand break repair via homologous recombinationIMP
GO:0000724double-strand break repair via homologous recombinationTAS
GO:0000730DNA recombinase assemblyTAS
GO:0006200ATP catabolic processIDA
GO:0006200ATP catabolic processIEA
GO:0006268DNA unwinding involved in DNA replicationIDA
GO:0006281DNA repairTAS
GO:0006302double-strand break repairTAS
GO:0006310DNA recombinationTAS
GO:0006312mitotic recombinationTAS
GO:0006974cellular response to DNA damage stimulusIDA
GO:0007126meiotic nuclear divisionISS
GO:0007131reciprocal meiotic recombinationTAS
GO:0010569regulation of double-strand break repair via homologous recombinationIDA
GO:0051106positive regulation of DNA ligationIDA
GO:0051260protein homooligomerizationIPI
GO:0071479cellular response to ionizing radiationIDA
GO:0072757cellular response to camptothecinIDA
Component
IDNameEvidence
GO:0000228nuclear chromosomeIDA
GO:0000793condensed chromosomeISS
GO:0000794condensed nuclear chromosomeISS
GO:0000800lateral elementIEA
GO:0005634nucleusIDA
GO:0005634nucleusISS
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0005759mitochondrial matrixIEA
GO:0005815microtubule organizing centerIEA
GO:0016605PML bodyIDA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0003684damaged DNA bindingIEA
GO:0003690double-stranded DNA bindingIDA
GO:0003697single-stranded DNA bindingIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0008022protein C-terminus bindingIPI
GO:0042802identical protein bindingIPI
GO:0043142single-stranded DNA-dependent ATPase activityIDA
GO:0070182DNA polymerase bindingIPI
GeneCards RAD51
UniProt Q06609
Vega OTTHUMG00000130067
MIM 179617
Ensembl ENSG00000051180
HGNC 9817
HPRD 01557

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RAD51 gene?

The RAD51 gene provides instructions for making a protein that is essential for repairing damaged DNA. Breaks in DNA can be caused by natural and medical radiation or other environmental exposures, and also occur when chromosomes exchange genetic material in preparation for cell division. The RAD51 protein binds to the DNA at the site of a break and encases it in a protein sheath, which is an essential first step in the repair process.

In the nucleus of many types of normal cells, the RAD51 protein interacts with many other proteins, including BRCA1 and BRCA2, to fix damaged DNA. The BRCA2 protein regulates the activity of the RAD51 protein by transporting it to sites of DNA damage in the nucleus. The interaction between the BRCA1 protein and the RAD51 protein is less clear, although research suggests that BRCA1 may also activate RAD51 in response to DNA damage. By helping repair DNA, these three proteins play a role in maintaining the stability of a cell's genetic information.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.