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RAG2 recombination activating gene 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000536 Homo sapiens recombination activating gene 2 (RAG2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001243785 Homo sapiens recombination activating gene 2 (RAG2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001243786 Homo sapiens recombination activating gene 2 (RAG2), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol RAG2
Entrez Gene ID 5897
Full Name recombination activating gene 2
Synonyms RAG-2
General protein information
Preferred Names
V(D)J recombination-activating protein 2
V(D)J recombination-activating protein 2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008].

MIM: 179616

Severe combined immunodeficiency, B cell-negative, 601457 (3);

mRNA Protein Product Sequence Price Select
NM_000536, 296040459 NP_000527, 151301080 V(D)J recombination-activating protein 2 ORF Sequence $550.00
NM_001243785, 344925857 NP_001230714, 344925858 V(D)J recombination-activating protein 2 ORF Sequence $550.00
NM_001243786, 344925929 NP_001230715, 344925930 V(D)J recombination-activating protein 2 ORF Sequence $550.00
hsa05340Primary immunodeficiency
hsa04068FoxO signaling pathway
Pathway Interaction Database
cmyb_pathwayC-MYB transcription factor network
Homo sapiens (human)RAG2NP_001230714.1
Pan troglodytes (chimpanzee)RAG2XP_521889.1
Macaca mulatta (Rhesus monkey)RAG2XP_001114734.2
Canis lupus familiaris (dog)RAG2XP_005631162.1
Bos taurus (cattle)RAG2NP_001075938.1
Mus musculus (house mouse)Rag2NP_033046.1
Rattus norvegicus (Norway rat)Rag2NP_001093998.1
Gallus gallus (chicken)RAG2XP_004941607.1
Danio rerio (zebrafish)rag2NP_571460.2
Xenopus (Silurana) tropicalis (western clawed frog)rag2XP_002937337.2
GO:0002326B cell lineage commitmentIEA
GO:0002331pre-B cell allelic exclusionISS
GO:0002358B cell homeostatic proliferationIEA
GO:0002360T cell lineage commitmentIEA
GO:0016568chromatin modificationIEA
GO:0030183B cell differentiationISS
GO:0033077T cell differentiation in thymusISS
GO:0033151V(D)J recombinationISS
GO:0046622positive regulation of organ growthIEA
GO:0003677DNA bindingIEA
GO:0003682chromatin bindingISS
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingISS
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingISS
GO:0008270zinc ion bindingISS
GO:0035064methylated histone bindingISS
GO:0035091phosphatidylinositol bindingISS
GO:0043325phosphatidylinositol-3,4-bisphosphate bindingISS
GO:0080025phosphatidylinositol-3,5-bisphosphate bindingISS
GeneCards RAG2
UniProt P55895
Vega OTTHUMG00000166393
MIM 179616
Ensembl ENSG00000175097
HGNC 9832
HPRD 08913

GeneRIFs: Gene References Into Functions What's a GeneRIF?


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