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RARA retinoic acid receptor, alpha [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20979 NM_001145302 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu21799 NM_001024809 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu26893 NM_001145301 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu26893 NM_000964 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu26893 XM_005257554 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu26893 XM_005257555 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu26893 XM_005257553 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu50570 XM_005257552 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu20979C NM_001145302 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 4, mRNA. Customized vector On-demand TBD $269.00
OHu21799C NM_001024809 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 2, mRNA. Customized vector On-demand TBD $269.00
OHu26893C NM_001145301 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 3, mRNA. Customized vector On-demand TBD $269.00
OHu26893C NM_000964 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 1, mRNA. Customized vector On-demand TBD $269.00
OHu26893C XM_005257554 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X3, mRNA. Customized vector On-demand TBD $269.00
OHu26893C XM_005257555 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X4, mRNA. Customized vector On-demand TBD $269.00
OHu26893C XM_005257553 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X2, mRNA. Customized vector On-demand TBD $269.00
OHu50570C XM_005257552 PREDICTED: Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant X1, mRNA. Customized vector On-demand TBD $269.00

*Business Day

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Gene Symbol RARA
Entrez Gene ID 5914
Full Name retinoic acid receptor, alpha
Synonyms NR1B1, RAR
General protein information
Preferred Names
retinoic acid receptor alpha
Names
retinoic acid receptor alpha
RAR-alpha
retinoic acid receptor, alpha polypeptide
nuclear receptor subfamily 1 group B member 1
retinoic acid nuclear receptor alpha variant 1
retinoic acid nuclear receptor alpha variant 2
nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21

Summary This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010].
Disorder

MIM: 180240

Leukemia, acute promyelocytic, 612376 (1)

mRNA Protein Product Sequence Price Select
NM_000964, 300388174 NP_000955, 4506419 retinoic acid receptor alpha isoform 1 ORF Sequence $550.00
NM_001024809, 300388162 NP_001019980, 67459914 retinoic acid receptor alpha isoform 2 ORF Sequence $550.00
NM_001145301, 300388161 NP_001138773, 223718064 retinoic acid receptor alpha isoform 1 ORF Sequence $550.00
NM_001145302, 300388173 NP_001138774, 223718070 retinoic acid receptor alpha isoform 4 ORF Sequence $400.00
XM_005257552, 578831218 XP_005257609, 530412616 retinoic acid receptor alpha isoform X1 ORF Sequence $550.00
XM_005257553, 530412617 XP_005257610, 530412618 retinoic acid receptor alpha isoform X2 ORF Sequence $550.00
XM_005257554, 530412619 XP_005257611, 530412620 retinoic acid receptor alpha isoform X3 ORF Sequence $550.00
XM_005257555, 530412621 XP_005257612, 530412622 retinoic acid receptor alpha isoform X4 ORF Sequence $550.00
KEGG
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP170Nuclear Receptors
WP716Vitamin A and carotenoid metabolism
WP286IL-3 Signaling Pathway
WP236Adipogenesis
WP299Nuclear receptors in lipid metabolism and toxicity
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
retinoic_acid_pathwayRetinoic acid receptors-mediated signaling
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_15525Nuclear Receptor transcription pathway
Homo sapiens (human)RARANP_001138773.1
Canis lupus familiaris (dog)RARANP_001012663.1
Bos taurus (cattle)RARANP_001014942.2
Mus musculus (house mouse)RaraNP_001170773.1
Rattus norvegicus (Norway rat)RaraNP_113716.2
Gallus gallus (chicken)RARANP_989867.1
Danio rerio (zebrafish)raraaNP_571481.2
Danio rerio (zebrafish)rarabNP_571474.1
Xenopus (Silurana) tropicalis (western clawed frog)raraNP_001164665.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001657ureteric bud developmentIEA
GO:0001889liver developmentIEA
GO:0003417growth plate cartilage developmentIEA
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0006468protein phosphorylationIMP
GO:0007165signal transductionIDA
GO:0007281germ cell developmentIEA
GO:0007283spermatogenesisIEA
GO:0007565female pregnancyIEA
GO:0008284positive regulation of cell proliferationIMP
GO:0008285negative regulation of cell proliferationIEA
GO:0010467gene expressionTAS
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIEA
GO:0030520intracellular estrogen receptor signaling pathwayIDA
GO:0030850prostate gland developmentIEA
GO:0030853negative regulation of granulocyte differentiationIDA
GO:0031641regulation of myelinationIEA
GO:0032355response to estradiolIDA
GO:0032526response to retinoic acidIMP
GO:0032689negative regulation of interferon-gamma productionIDA
GO:0032720negative regulation of tumor necrosis factor productionIDA
GO:0032736positive regulation of interleukin-13 productionIDA
GO:0032753positive regulation of interleukin-4 productionIDA
GO:0032754positive regulation of interleukin-5 productionIDA
GO:0033189response to vitamin AIEA
GO:0034097response to cytokineIEA
GO:0035264multicellular organism growthIEA
GO:0042981regulation of apoptotic processIEA
GO:0043277apoptotic cell clearanceIMP
GO:0043401steroid hormone mediated signaling pathwayIEA
GO:0043551regulation of phosphatidylinositol 3-kinase activityIEA
GO:0045471response to ethanolIEA
GO:0045630positive regulation of T-helper 2 cell differentiationIDA
GO:0045666positive regulation of neuron differentiationIEA
GO:0045787positive regulation of cell cycleIMP
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0045947negative regulation of translational initiationIEA
GO:0048167regulation of synaptic plasticityIEA
GO:0048384retinoic acid receptor signaling pathwayIMP
GO:0051099positive regulation of bindingIMP
GO:0051897positive regulation of protein kinase B signalingIEA
GO:0055012ventricular cardiac muscle cell differentiationIEA
GO:0060010Sertoli cell fate commitmentIEA
GO:0060591chondroblast differentiationIEA
GO:0061037negative regulation of cartilage developmentIEA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEA
GO:0071222cellular response to lipopolysaccharideIEA
GO:0071300cellular response to retinoic acidIDA
GO:0071391cellular response to estrogen stimulusIDA
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIDA
GO:0009986cell surfaceIC
GO:0030425dendriteIEA
GO:0043025neuronal cell bodyIEA
GO:0048471perinuclear region of cytoplasmIEA
Function
IDNameEvidence
GO:0000900translation repressor activity, nucleic acid bindingIEA
GO:0001972retinoic acid bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003707steroid hormone receptor activityIEA
GO:0003708retinoic acid receptor activityIDA
GO:0003713transcription coactivator activityIDA
GO:0003713transcription coactivator activityIMP
GO:0003714transcription corepressor activityIDA
GO:0005102receptor bindingIDA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0008144drug bindingIEA
GO:0008270zinc ion bindingIEA
GO:0019899enzyme bindingIPI
GO:0019904protein domain specific bindingIPI
GO:0031490chromatin DNA bindingIDA
GO:0035014phosphatidylinositol 3-kinase regulator activityIEA
GO:0043422protein kinase B bindingIPI
GO:0043565sequence-specific DNA bindingIEA
GO:0044323retinoic acid-responsive element bindingIDA
GO:0046982protein heterodimerization activityIDA
GO:0048027mRNA 5'-UTR bindingIEA
GO:0051018protein kinase A bindingIDA
GeneCards RARA
UniProt F1D8N9, A8K840, Q6I9R7, A8MUP8, P10276
MIM 180240
HGNC 9864
HPRD 06769

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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