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RASA1 RAS p21 protein activator (GTPase activating protein) 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002890 Homo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_022650 Homo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol RASA1
Entrez Gene ID 5921
Full Name RAS p21 protein activator (GTPase activating protein) 1
General protein information
Preferred Names
ras GTPase-activating protein 1
ras GTPase-activating protein 1
triphosphatase-activating protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].

MIM: 139150

Parkes Weber slndrome, 608355 (3); Capillary

mRNA Protein Product Sequence Price Select
NM_002890, 347360924 NP_002881, 4506431 ras GTPase-activating protein 1 isoform 1 ORF Sequence $1500.00
NM_022650, 347360923 NP_072179, 12545406 ras GTPase-activating protein 1 isoform 2 ORF Sequence $750.00
hsa04360Axon guidance
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
WP382MAPK signaling pathway
WP437EGFR1 Signaling Pathway
WP395IL-4 signaling Pathway
WP304Kit Receptor Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP581EPO Receptor Signaling
WP2263Prostate Cancer
Pathway Interaction Database
aurora_a_pathwayAurora A signaling
vegfr1_pathwayVEGFR1 specific signals
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
il2_1pathwayIL2-mediated signaling events
ret_pathwaySignaling events regulated by Ret tyrosine kinase
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
ephbfwdpathwayEPHB forward signaling
insulin_pathwayInsulin Pathway
bcr_5pathwayBCR signaling pathway
aurora_b_pathwayAurora B signaling
syndecan_2_pathwaySyndecan-2-mediated signaling events
fcer1pathwayFc-epsilon receptor I signaling in mast cells
pdgfrbpathwayPDGFR-beta signaling pathway
fak_pathwaySignaling events mediated by focal adhesion kinase
REACT_16888Signaling by PDGF
REACT_17025Downstream signal transduction
REACT_111102Signal Transduction
Homo sapiens (human)RASA1NP_002881.1
Pan troglodytes (chimpanzee)RASA1XP_517663.3
Macaca mulatta (Rhesus monkey)RASA1XP_001084074.2
Canis lupus familiaris (dog)RASA1XP_536302.3
Bos taurus (cattle)RASA1NP_776874.1
Mus musculus (house mouse)Rasa1NP_663427.2
Rattus norvegicus (Norway rat)Rasa1NP_037267.1
Gallus gallus (chicken)RASA1XP_424907.4
Danio rerio (zebrafish)rasa1aXP_001342009.2
Drosophila melanogaster (fruit fly)vapNP_727926.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC100135092NP_001107303.1
GO:0000281mitotic cytokinesisISS
GO:0001953negative regulation of cell-matrix adhesionIDA
GO:0007162negative regulation of cell adhesionIDA
GO:0007165signal transductionIDA
GO:0008360regulation of cell shapeNAS
GO:0009790embryo developmentISS
GO:0030833regulation of actin filament polymerizationIDA
GO:0032320positive regulation of Ras GTPase activityIBA
GO:0035556intracellular signal transductionNAS
GO:0043524negative regulation of neuron apoptotic processISS
GO:0046580negative regulation of Ras protein signal transductionIBA
GO:0051252regulation of RNA metabolic processNAS
GO:0031235intrinsic component of the cytoplasmic side of the plasma membraneIBA
GO:0001948glycoprotein bindingIPI
GO:0005099Ras GTPase activator activityIBA
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0019870potassium channel inhibitor activityNAS
GO:0051020GTPase bindingIPI
GeneCards RASA1
UniProt Q59GK3, P20936
Vega OTTHUMG00000162605
MIM 139150
Ensembl ENSG00000145715
HGNC 9871
HPRD 00745

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RASA1 gene?

The RASA1 gene provides instructions for making a protein called p120-RasGAP. This protein helps regulate the RAS/MAPK signaling pathway, which transmits signals from outside the cell to the cell's nucleus. The RAS/MAPK signaling pathway helps direct several important cell functions, including the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), and cell movement. The p120-RasGAP protein is a negative regulator of the RAS/MAPK signaling pathway, which means it is involved in turning off these signals when they are not needed.

The exact role of p120-RasGAP is not fully understood. However, it appears to be essential for the normal development of the vascular system, which is the complex network of arteries, veins, and capillaries that carry blood to and from the heart.


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