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RASA1 RAS p21 protein activator (GTPase activating protein) 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002890 Homo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_022650 Homo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol RASA1
Entrez Gene ID 5921
Full Name RAS p21 protein activator (GTPase activating protein) 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].

MIM: 139150

Parkes Weber slndrome, 608355 (3); Capillary

mRNA Protein Product Sequence Price Select
NM_002890, 347360924 NP_002881, 4506431 ras GTPase-activating protein 1 isoform 1 ORF Sequence $1500.00
NM_022650, 347360923 NP_072179, 12545406 ras GTPase-activating protein 1 isoform 2 ORF Sequence $750.00
hsa04010MAPK signaling pathway
hsa04360Axon guidance
Pathway Interaction Database
aurora_b_pathwayAurora B signaling
bcr_5pathwayBCR signaling pathway
ephbfwdpathwayEPHB forward signaling
vegfr1_pathwayVEGFR1 specific signals
ret_pathwaySignaling events regulated by Ret tyrosine kinase
pdgfrbpathwayPDGFR-beta signaling pathway
syndecan_2_pathwaySyndecan-2-mediated signaling events
fak_pathwaySignaling events mediated by focal adhesion kinase
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
il2_1pathwayIL2-mediated signaling events
insulin_pathwayInsulin Pathway
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
aurora_a_pathwayAurora A signaling
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
fcer1pathwayFc-epsilon receptor I signaling in mast cells
WP395IL-4 signaling Pathway
WP382MAPK signaling pathway
WP304Kit Receptor Signaling Pathway
WP581EPO Receptor Signaling
WP437EGFR1 Signaling Pathway
WP313Signaling of Hepatocyte Growth Factor Receptor
WP23B Cell Receptor Signaling Pathway
REACT_17025Downstream signal transduction
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
Homo sapiens (human)RASA1NP_002881.1
Pan troglodytes (chimpanzee)RASA1XP_517663.3
Macaca mulatta (Rhesus monkey)RASA1XP_001084074.2
Canis lupus familiaris (dog)RASA1XP_536302.3
Bos taurus (cattle)RASA1NP_776874.1
Mus musculus (house mouse)Rasa1NP_663427.2
Rattus norvegicus (Norway rat)Rasa1NP_037267.1
Gallus gallus (chicken)RASA1XP_424907.3
Danio rerio (zebrafish)rasa1aXP_001342009.1
Drosophila melanogaster (fruit fly)vapNP_523361.1
GeneCards RASA1
PDB 2GQI, 4FSS, 2J05, 2J06, 2GSB, 1WER, 1WQ1
UniProt Q59GK3, P20936
MIM 139150
Ensembl ENSG00000145715
HGNC 9871
HPRD 00745

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
ras GTPase-activating protein 1
ras GTPase-activating protein 1
triphosphatase-activating protein


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