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TRPV4 transient receptor potential cation channel, subfamily V, member 4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21707 NM_021625 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu22834 NM_001177428 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu23056 NM_147204 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25097 NM_001177431 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu27266 NM_001177433 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu21707 XM_005253918 PREDICTED: Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25097 XM_005253919 PREDICTED: Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu21707C NM_021625 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu22834C NM_001177428 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 5, mRNA. Customized vector On-demand 12-14 $329.00
OHu23056C NM_147204 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu25097C NM_001177431 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 4, mRNA. Customized vector On-demand 12-14 $329.00
OHu27266C NM_001177433 Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu21707C XM_005253918 PREDICTED: Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu25097C XM_005253919 PREDICTED: Homo sapiens transient receptor potential cation channel, subfamily V, member 4 (TRPV4), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol TRPV4
Entrez Gene ID 59341
Full Name transient receptor potential cation channel, subfamily V, member 4
Synonyms CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
General protein information
Preferred Names
transient receptor potential cation channel subfamily V member 4
Names
transient receptor potential cation channel subfamily V member 4
osm-9-like TRP channel 4
vanilloid receptor-like channel 2
transient receptor potential protein 12
OSM9-like transient receptor potential channel 4
osmosensitive transient receptor potential channel 4
vanilloid receptor-related osmotically activated channel
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.1

Summary This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010].
Disorder

MIM: 605427

Brachyolmia type 3, 113500 (3); Spondylometaphyseal dysplasia,

mRNA Protein Product Sequence Price Select
NM_001177428, 294459964 NP_001170899, 294459965 transient receptor potential cation channel subfamily V member 4 isoform e ORF Sequence $750.00
NM_001177431, 294459970 NP_001170902, 294459971 transient receptor potential cation channel subfamily V member 4 isoform d ORF Sequence $750.00
NM_001177433, 294459976 NP_001170904, 294459977 transient receptor potential cation channel subfamily V member 4 isoform c ORF Sequence $700.00
NM_021625, 294459961 NP_067638, 22547184 transient receptor potential cation channel subfamily V member 4 isoform a ORF Sequence $750.00
NM_147204, 294459960 NP_671737, 22547180 transient receptor potential cation channel subfamily V member 4 isoform b ORF Sequence $750.00
XM_005253918, 530401384 XP_005253975, 530401385 transient receptor potential cation channel subfamily V member 4 isoform X1 ORF Sequence $750.00
XM_005253919, 530401386 XP_005253976, 530401387 transient receptor potential cation channel subfamily V member 4 isoform X2 ORF Sequence $750.00
KEGG
hsa04750Inflammatory mediator regulation of TRP channels
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25300Ion channel transport
REACT_169333TRP channels
REACT_160189Stimuli-sensing channels
Homo sapiens (human)TRPV4NP_067638.3
Pan troglodytes (chimpanzee)TRPV4XP_003314024.1
Canis lupus familiaris (dog)TRPV4NP_001120787.1
Bos taurus (cattle)TRPV4NP_001179314.1
Mus musculus (house mouse)Trpv4NP_071300.2
Rattus norvegicus (Norway rat)Trpv4NP_076460.1
Gallus gallus (chicken)TRPV4NP_990023.1
Danio rerio (zebrafish)trpv4NP_001036195.1
Xenopus (Silurana) tropicalis (western clawed frog)trpv4XP_002932129.1
Process
IDNameEvidence
GO:0006816calcium ion transportIDA
GO:0006816calcium ion transportNAS
GO:0006874cellular calcium ion homeostasisIDA
GO:0006884cell volume homeostasisTAS
GO:0007015actin filament organizationISS
GO:0007043cell-cell junction assemblyISS
GO:0007204positive regulation of cytosolic calcium ion concentrationIDA
GO:0007231osmosensory signaling pathwayISS
GO:0007231osmosensory signaling pathwayTAS
GO:0008219cell deathIEA
GO:0009612response to mechanical stimulusTAS
GO:0010977negative regulation of neuron projection developmentISS
GO:0030103vasopressin secretionIEA
GO:0031117positive regulation of microtubule depolymerizationISS
GO:0031532actin cytoskeleton reorganizationISS
GO:0034220ion transmembrane transportTAS
GO:0034605cellular response to heatISS
GO:0042538hyperosmotic salinity responseIEA
GO:0043622cortical microtubule organizationISS
GO:0046785microtubule polymerizationISS
GO:0047484regulation of response to osmotic stressIEA
GO:0055085transmembrane transportTAS
GO:0070509calcium ion importISS
GO:0070588calcium ion transmembrane transportTAS
GO:0071470cellular response to osmotic stressISS
GO:0071476cellular hypotonic responseISS
Component
IDNameEvidence
GO:0005881cytoplasmic microtubuleISS
GO:0005886plasma membraneIDA
GO:0005886plasma membraneISS
GO:0005886plasma membraneTAS
GO:0005912adherens junctionISS
GO:0005925focal adhesionISS
GO:0005929ciliumIEA
GO:0009986cell surfaceIEA
GO:0016021integral component of membraneNAS
GO:0030027lamellipodiumISS
GO:0030175filopodiumISS
GO:0030426growth coneISS
GO:0030864cortical actin cytoskeletonISS
GO:0031410cytoplasmic vesicleIEA
GO:0032587ruffle membraneISS
Function
IDNameEvidence
GO:0003779actin bindingISS
GO:0005034osmosensor activityIEA
GO:0005080protein kinase C bindingISS
GO:0005261cation channel activityIDA
GO:0005262calcium channel activityIDA
GO:0005516calmodulin bindingIMP
GO:0005524ATP bindingIEA
GO:0008017microtubule bindingISS
GO:0019901protein kinase bindingIPI
GO:0042169SH2 domain bindingISS
GO:0043014alpha-tubulin bindingISS
GO:0048487beta-tubulin bindingISS
GO:0051015actin filament bindingISS
GeneCards TRPV4
UniProt Q9HBA0
Vega OTTHUMG00000169277
MIM 605427
Ensembl ENSG00000111199
HGNC 18083
HPRD 05667

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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