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BCL2 B-cell CLL/lymphoma 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000633 Homo sapiens B-cell CLL/lymphoma 2 (BCL2), nuclear gene encoding mitochondrial protein, transcript variant alpha, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 TBD
NM_000657 Homo sapiens B-cell CLL/lymphoma 2 (BCL2), nuclear gene encoding mitochondrial protein, transcript variant beta, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol BCL2
Entrez Gene ID 596
Full Name B-cell CLL/lymphoma 2
Synonyms Bcl-2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008].

MIM: 151430

Leukemia/lymphoma, B-cell, 2 (3)

mRNA Protein Product Sequence Price Select
NM_000633, 72198188 NP_000624, 72198189 apoptosis regulator Bcl-2 alpha isoform ORF Sequence $159.00
NM_000657, 72198345 NP_000648, 72198346 apoptosis regulator Bcl-2 beta isoform ORF Sequence $250.00
hsa04510Focal adhesion
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa04064NF-kappa B signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa05161Hepatitis B
hsa05222Small cell lung cancer
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04151PI3K-Akt signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa05169Epstein-Barr virus infection
hsa04066HIF-1 signaling pathway
hsa05210Colorectal cancer
WP314FAS pathway and Stress induction of HSP regulation
WP710DNA damage response (only ATM dependent)
WP23B Cell Receptor Signaling Pathway
WP306Focal Adhesion
WP49IL-2 Signaling Pathway
WP1971Integrated Cancer pathway
WP2332Interleukin-11 Signaling Pathway
WP615Senescence and Autophagy
WP1984Integrated Breast Cancer Pathway
WP1742TP53 network
WP712Estrogen signaling pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2256Integrated Pancreatic Cancer Pathway
WP1772Apoptosis Modulation and Signaling
WP286IL-3 Signaling Pathway
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
myc_represspathwayValidated targets of C-MYC transcriptional repression
rxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
epopathwayEPO signaling pathway
hivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
il2_1pathwayIL2-mediated signaling events
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
ceramide_pathwayCeramide signaling pathway
cmyb_pathwayC-MYB transcription factor network
atf2_pathwayATF-2 transcription factor network
il2_stat5pathwayIL2 signaling events mediated by STAT5
caspase_pathwayCaspase cascade in apoptosis
il2_pi3kpathwayIL2 signaling events mediated by PI3K
REACT_75927The NLRP1 inflammasome
REACT_964Intrinsic Pathway for Apoptosis
REACT_6802Innate Immune System
REACT_697Activation of BH3-only proteins
REACT_330BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_6900Immune System
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_549Activation of BAD and translocation to mitochondria
Homo sapiens (human)BCL2NP_000624.2
Pan troglodytes (chimpanzee)BCL2XP_001145537.1
Canis lupus familiaris (dog)BCL2NP_001002949.1
Bos taurus (cattle)BCL2NP_001159958.1
Mus musculus (house mouse)Bcl2NP_033871.2
Rattus norvegicus (Norway rat)Bcl2NP_058689.1
Gallus gallus (chicken)BCL2NP_990670.1
GeneCards BCL2
PDB 1YSW, 2XA0, 1G5M, 1GJH, 2O21, 4AQ3, 2O2F, 2W3L, 2O22
UniProt C9JHD5, P10415
MIM 151430
Ensembl ENSG00000171791
HGNC 990
HPRD 01045

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
apoptosis regulator Bcl-2
apoptosis regulator Bcl-2
protein phosphatase 1, regulatory subunit 50


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