Sequence in raw or FASTA format:

BCL2 B-cell CLL/lymphoma 2 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	BCL2
Entrez Gene ID	596
Full Name	B-cell CLL/lymphoma 2
Synonyms	Bcl-2
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:18 Map Location:18q21.33\|18q21.3
Summary	This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq].
Disorder	MIM: 151430 Leukemia/lymphoma, B-cell, 2 (3)

mRNA	NM_000633, 72198188
Protein	NP_000624, 72198189
Product	apoptosis regulator Bcl-2 alpha isoform
RefSeq Status	REVIEWED
mRNA	NM_000657, 72198345
Protein	NP_000648, 72198346
Product	apoptosis regulator Bcl-2 beta isoform
RefSeq Status	REVIEWED

KEGG

hsa04141	Protein processing in endoplasmic reticulum
hsa04210	Apoptosis
hsa05222	Small cell lung cancer
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa04722	Neurotrophin signaling pathway
hsa05145	Toxoplasmosis
hsa05210	Colorectal cancer
hsa05200	Pathways in cancer
hsa05215	Prostate cancer
hsa04510	Focal adhesion

WikiPathways

WP615	Senescence and Autophagy
WP254	Apoptosis
WP712	Estrogen signaling pathway
WP286	IL-3 Signaling Pathway
WP23	B Cell Receptor Signaling Pathway
WP306	Focal Adhesion
WP49	IL-2 Signaling Pathway
WP314	FAS pathway and Stress induction of HSP regulation

Pathway Interaction Database

nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes
hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha
il2_1pathway	IL2-mediated signaling events
cmyb_pathway	C-MYB transcription factor network
ceramide_pathway	Ceramide signaling pathway
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
atf2_pathway	ATF-2 transcription factor network
il2_stat5pathway	IL2 signaling events mediated by STAT5
caspase_pathway	Caspase cascade in apoptosis
il2_pi3kpathway	IL2 signaling events mediated by PI3K
rxr_vdr_pathway	RXR and RAR heterodimerization with other nuclear receptor
epopathway	EPO signaling pathway
p53downstreampathway	Direct p53 effectors
myc_represspathway	Validated targets of C-MYC transcriptional repression

Reactome

REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_549	Activation of BAD and translocation to mitochondria
REACT_964	Intrinsic Pathway for Apoptosis
REACT_697	Activation of BH3-only proteins

Homo sapiens (human)	BCL2	NP_000624.2
Pan troglodytes (chimpanzee)	BCL2	XP_001145537.1
Canis lupus familiaris (dog)	BCL2	NP_001002949.1
Bos taurus (cattle)	BCL2	XP_586976.3
Mus musculus (house mouse)	Bcl2	NP_033871.2
Rattus norvegicus (Norway rat)	Bcl2	NP_058689.1
Gallus gallus (chicken)	BCL2	NP_990670.1

Process

ID	Name	Evidence
GO:0000082	G1/S transition of mitotic cell cycle	IEA
GO:0000209	protein polyubiquitination	IDA
GO:0000902	cell morphogenesis	IEA
GO:0001541	ovarian follicle development	IEA
GO:0001656	metanephros development	IEA
GO:0001657	ureteric bud development	IEA
GO:0001658	branching involved in ureteric bud morphogenesis	IEA
GO:0001662	behavioral fear response	IEA
GO:0001666	response to hypoxia	IEA
GO:0001782	B cell homeostasis	IEA
GO:0001836	release of cytochrome c from mitochondria	ISS
GO:0001836	release of cytochrome c from mitochondria	NAS
GO:0001952	regulation of cell-matrix adhesion	IEA
GO:0002320	lymphoid progenitor cell differentiation	IEA
GO:0002326	B cell lineage commitment	IEA
GO:0002360	T cell lineage commitment	IEA
GO:0002520	immune system development	IEA
GO:0003014	renal system process	IEA
GO:0006470	protein dephosphorylation	IEA
GO:0006582	melanin metabolic process	IEA
GO:0006808	regulation of nitrogen utilization	IEA
GO:0006915	apoptosis	TAS
GO:0006916	anti-apoptosis	IDA
GO:0006959	humoral immune response	TAS
GO:0006974	response to DNA damage stimulus	IMP
GO:0006979	response to oxidative stress	IEA
GO:0007015	actin filament organization	IEA
GO:0007565	female pregnancy	NAS
GO:0007569	cell aging	IEA
GO:0007584	response to nutrient	IEA
GO:0008219	cell death	IDA
GO:0008284	positive regulation of cell proliferation	IEA
GO:0008584	male gonad development	IEA
GO:0008629	induction of apoptosis by intracellular signals	TAS
GO:0008633	activation of pro-apoptotic gene products	EXP
GO:0008633	activation of pro-apoptotic gene products	TAS
GO:0009314	response to radiation	NAS
GO:0009408	response to heat	IEA
GO:0009605	response to external stimulus	IEA
GO:0009636	response to toxin	IDA
GO:0009791	post-embryonic development	IEA
GO:0009887	organ morphogenesis	IEA
GO:0010035	response to inorganic substance	IEA
GO:0010039	response to iron ion	IDA
GO:0010044	response to aluminum ion	IEA
GO:0010224	response to UV-B	IEA
GO:0010332	response to gamma radiation	IEA
GO:0010468	regulation of gene expression	IEA
GO:0010523	negative regulation of calcium ion transport into cytosol	IEA
GO:0010559	regulation of glycoprotein biosynthetic process	IEA
GO:0014031	mesenchymal cell development	IEA
GO:0014042	positive regulation of neuron maturation	IEA
GO:0014911	positive regulation of smooth muscle cell migration	IEA
GO:0016337	cell-cell adhesion	IEA
GO:0018107	peptidyl-threonine phosphorylation	IEA
GO:0021747	cochlear nucleus development	IEA
GO:0022612	gland morphogenesis	IEA
GO:0022898	regulation of transmembrane transporter activity	IDA
GO:0030097	hemopoiesis	IEA
GO:0030279	negative regulation of ossification	IEA
GO:0030307	positive regulation of cell growth	IDA
GO:0030308	negative regulation of cell growth	IEA
GO:0030336	negative regulation of cell migration	IEA
GO:0030890	positive regulation of B cell proliferation	IMP
GO:0031000	response to caffeine	IEA
GO:0031069	hair follicle morphogenesis	IEA
GO:0031103	axon regeneration	IEA
GO:0031647	regulation of protein stability	IEA
GO:0032469	endoplasmic reticulum calcium ion homeostasis	IEA
GO:0032835	glomerulus development	IEA
GO:0032848	negative regulation of cellular pH reduction	IDA
GO:0032868	response to insulin stimulus	IEA
GO:0032880	regulation of protein localization	IEA
GO:0033033	negative regulation of myeloid cell apoptosis	IEA
GO:0033077	T cell differentiation in thymus	IEA
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IEA
GO:0033591	response to L-ascorbic acid	IEA
GO:0033689	negative regulation of osteoblast proliferation	IEA
GO:0034097	response to cytokine stimulus	IDA
GO:0034349	glial cell apoptosis	IEA
GO:0035094	response to nicotine	IDA
GO:0035265	organ growth	IEA
GO:0040018	positive regulation of multicellular organism growth	IEA
GO:0042100	B cell proliferation	IDA
GO:0042493	response to drug	IDA
GO:0042493	response to drug	IMP
GO:0042542	response to hydrogen peroxide	IEA
GO:0043029	T cell homeostasis	IEA
GO:0043066	negative regulation of apoptosis	IDA
GO:0043085	positive regulation of catalytic activity	IEA
GO:0043375	CD8-positive, alpha-beta T cell lineage commitment	IEA
GO:0043496	regulation of protein homodimerization activity	IDA
GO:0043497	regulation of protein heterodimerization activity	IDA
GO:0043524	negative regulation of neuron apoptosis	IDA
GO:0043583	ear development	IEA
GO:0043627	response to estrogen stimulus	IEA
GO:0045069	regulation of viral genome replication	IEA
GO:0045471	response to ethanol	IEA
GO:0045636	positive regulation of melanocyte differentiation	IEA
GO:0045930	negative regulation of mitotic cell cycle	IEA
GO:0046671	negative regulation of retinal cell programmed cell death	IEA
GO:0046688	response to copper ion	IEA
GO:0046902	regulation of mitochondrial membrane permeability	ISS
GO:0048041	focal adhesion assembly	IEA
GO:0048087	positive regulation of developmental pigmentation	IEA
GO:0048536	spleen development	IEA
GO:0048538	thymus development	IEA
GO:0048546	digestive tract morphogenesis	IEA
GO:0048589	developmental growth	IEA
GO:0048599	oocyte development	IEA
GO:0048743	positive regulation of skeletal muscle fiber development	IEA
GO:0048753	pigment granule organization	IEA
GO:0048873	homeostasis of number of cells within a tissue	IEA
GO:0050853	B cell receptor signaling pathway	IMP
GO:0051402	neuron apoptosis	TAS
GO:0051412	response to corticosterone stimulus	IEA
GO:0051593	response to folic acid	IEA
GO:0051607	defense response to virus	IDA
GO:0051726	regulation of cell cycle	IEA
GO:0051789	response to protein stimulus	IEA
GO:0051881	regulation of mitochondrial membrane potential	ISS
GO:0051902	negative regulation of mitochondrial depolarization	TAS
GO:0051924	regulation of calcium ion transport	IDA
GO:0070059	apoptosis in response to endoplasmic reticulum stress	IDA

Component

ID	Name	Evidence
GO:0005622	intracellular	IEA
GO:0005624	membrane fraction	IEA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IDA
GO:0005741	mitochondrial outer membrane	EXP
GO:0005741	mitochondrial outer membrane	IDA
GO:0005741	mitochondrial outer membrane	TAS
GO:0005783	endoplasmic reticulum	IDA
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0005792	microsome	IEA
GO:0005829	cytosol	IEA
GO:0016020	membrane	IDA
GO:0031965	nuclear membrane	IDA
GO:0043209	myelin sheath	IEA
GO:0046930	pore complex	IDA

Function

ID	Name	Evidence
GO:0002020	protease binding	IDA
GO:0005515	protein binding	IPI
GO:0008134	transcription factor binding	IEA
GO:0015267	channel activity	IDA
GO:0042802	identical protein binding	IPI
GO:0042803	protein homodimerization activity	IPI
GO:0043565	sequence-specific DNA binding	IDA
GO:0046982	protein heterodimerization activity	IPI
GO:0051434	BH3 domain binding	IPI
GO:0051721	protein phosphatase 2A binding	IEA

GeneCards	BCL2
PDB	1YSW, 2XA0, 1G5M, 1GJH, 2O21, 2O2F, 2W3L, 2O22
UniProt	C9JHD5, P10415
MIM	151430
Ensembl	ENSG00000171791
HGNC	990
HPRD	01045

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000633	Homo sapiens B-cell CLL/lymphoma 2 (BCL2), nuclear gene encoding mitochondrial protein, transcript variant alpha, mRNA.	Full Length	$2921.40
NM_000633		ORF Sequence	$208.80
NM_000657	Homo sapiens B-cell CLL/lymphoma 2 (BCL2), nuclear gene encoding mitochondrial protein, transcript variant beta, mRNA.	Full Length	$350.03
NM_000657		ORF Sequence	$179.22