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BCL2 B-cell CLL/lymphoma 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000633 Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant alpha, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 TBD
NM_000657 Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant beta, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722523 PREDICTED: Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol BCL2
Entrez Gene ID 596
Full Name B-cell CLL/lymphoma 2
Synonyms Bcl-2, PPP1R50
General protein information
Preferred Names
apoptosis regulator Bcl-2
Names
apoptosis regulator Bcl-2
protein phosphatase 1, regulatory subunit 50
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q21.3

Summary This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008].
Disorder

MIM: 151430

Leukemia/lymphoma, B-cell, 2 (3)

mRNA Protein Product Sequence Price Select
NM_000633, 72198188 NP_000624, 72198189 apoptosis regulator Bcl-2 alpha isoform ORF Sequence $159.00
NM_000657, 72198345 NP_000648, 72198346 apoptosis regulator Bcl-2 beta isoform ORF Sequence $250.00
XM_006722523, 578832640 XP_006722586, 578832641 apoptosis regulator Bcl-2 isoform X1 ORF Sequence $250.00
KEGG
hsa04510Focal adhesion
hsa04210Apoptosis
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05215Prostate cancer
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa04722Neurotrophin signaling pathway
hsa05145Toxoplasmosis
hsa04141Protein processing in endoplasmic reticulum
hsa05152Tuberculosis
hsa04725Cholinergic synapse
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04066HIF-1 signaling pathway
hsa04064NF-kappa B signaling pathway
hsa05169Epstein-Barr virus infection
hsa05206MicroRNAs in cancer
hsa04261Adrenergic signaling in cardiomyocytes
WikiPathways
WP254Apoptosis
WP615Senescence and Autophagy
WP1984Integrated Breast Cancer Pathway
WP1772Apoptosis Modulation and Signaling
WP712Estrogen signaling pathway
WP286IL-3 Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP49IL-2 Signaling pathway
WP314FAS pathway and Stress induction of HSP regulation
WP23B Cell Receptor Signaling Pathway
WP1742TP53 network
WP2332Interleukin-11 Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP1971Integrated Cancer pathway
WP2263Prostate Cancer
WP2355Corticotropin-releasing hormone
WP1438Influenza A virus infection
WP2447Amyotrophic lateral sclerosis (ALS)
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
il2_pi3kpathwayIL2 signaling events mediated by PI3K
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
hivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
atf2_pathwayATF-2 transcription factor network
caspase_pathwayCaspase cascade in apoptosis
il2_1pathwayIL2-mediated signaling events
rxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
il2_stat5pathwayIL2 signaling events mediated by STAT5
ceramide_pathwayCeramide signaling pathway
cmyb_pathwayC-MYB transcription factor network
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
epopathwayEPO signaling pathway
myc_represspathwayValidated targets of C-MYC transcriptional repression
Reactome
REACT_578Apoptosis
REACT_549Activation of BAD and translocation to mitochondria
REACT_964Intrinsic Pathway for Apoptosis
REACT_330BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_697Activation of BH3-only proteins
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75900Inflammasomes
REACT_75927The NLRP1 inflammasome
Homo sapiens (human)BCL2NP_000624.2
Pan troglodytes (chimpanzee)BCL2XP_001145537.1
Canis lupus familiaris (dog)BCL2NP_001002949.1
Bos taurus (cattle)BCL2NP_001159958.1
Mus musculus (house mouse)Bcl2NP_033871.2
Rattus norvegicus (Norway rat)Bcl2NP_058689.1
Gallus gallus (chicken)BCL2NP_990670.1
Xenopus (Silurana) tropicalis (western clawed frog)bcl2XP_002934442.1
Process
IDNameEvidence
GO:0000209protein polyubiquitinationIDA
GO:0001101response to acidIEA
GO:0001503ossificationIEA
GO:0001541ovarian follicle developmentIEA
GO:0001656metanephros developmentIEA
GO:0001658branching involved in ureteric bud morphogenesisIEA
GO:0001662behavioral fear responseIEA
GO:0001782B cell homeostasisIEA
GO:0001836release of cytochrome c from mitochondriaISS
GO:0001836release of cytochrome c from mitochondriaNAS
GO:0001952regulation of cell-matrix adhesionIEA
GO:0002320lymphoid progenitor cell differentiationIEA
GO:0002326B cell lineage commitmentIEA
GO:0002931response to ischemiaIEA
GO:0003014renal system processIEA
GO:0006470protein dephosphorylationIEA
GO:0006582melanin metabolic processIEA
GO:0006808regulation of nitrogen utilizationIEA
GO:0006915apoptotic processIDA
GO:0006915apoptotic processTAS
GO:0006959humoral immune responseTAS
GO:0006974cellular response to DNA damage stimulusIMP
GO:0007015actin filament organizationIEA
GO:0007409axonogenesisIEA
GO:0007565female pregnancyNAS
GO:0007569cell agingIEA
GO:0008584male gonad developmentIEA
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIDA
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIBA
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stressIEA
GO:0009314response to radiationNAS
GO:0009636response to toxic substanceIDA
GO:0009791post-embryonic developmentIEA
GO:0010039response to iron ionIDA
GO:0010224response to UV-BIEA
GO:0010332response to gamma radiationIEA
GO:0010507negative regulation of autophagyTAS
GO:0010523negative regulation of calcium ion transport into cytosolIEA
GO:0010559regulation of glycoprotein biosynthetic processIEA
GO:0014031mesenchymal cell developmentIEA
GO:0014042positive regulation of neuron maturationIEA
GO:0014911positive regulation of smooth muscle cell migrationIEA
GO:0016049cell growthIEA
GO:0016337single organismal cell-cell adhesionIEA
GO:0018105peptidyl-serine phosphorylationIEA
GO:0018107peptidyl-threonine phosphorylationIEA
GO:0021747cochlear nucleus developmentIEA
GO:0022612gland morphogenesisIEA
GO:0022898regulation of transmembrane transporter activityIDA
GO:0030279negative regulation of ossificationIEA
GO:0030307positive regulation of cell growthIDA
GO:0030308negative regulation of cell growthIEA
GO:0030318melanocyte differentiationIEA
GO:0030336negative regulation of cell migrationIEA
GO:0030890positive regulation of B cell proliferationIMP
GO:0031069hair follicle morphogenesisIEA
GO:0031103axon regenerationIEA
GO:0031647regulation of protein stabilityIEA
GO:0032469endoplasmic reticulum calcium ion homeostasisTAS
GO:0032835glomerulus developmentIEA
GO:0032848negative regulation of cellular pH reductionIDA
GO:0033033negative regulation of myeloid cell apoptotic processIEA
GO:0033077T cell differentiation in thymusIEA
GO:0033138positive regulation of peptidyl-serine phosphorylationIEA
GO:0033689negative regulation of osteoblast proliferationIEA
GO:0034097response to cytokineIDA
GO:0035094response to nicotineIDA
GO:0035265organ growthIEA
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTAS
GO:0040018positive regulation of multicellular organism growthIEA
GO:0042100B cell proliferationIDA
GO:0042149cellular response to glucose starvationIEA
GO:0042493response to drugIDA
GO:0042493response to drugIMP
GO:0042542response to hydrogen peroxideIEA
GO:0043029T cell homeostasisIEA
GO:0043066negative regulation of apoptotic processIDA
GO:0043066negative regulation of apoptotic processIMP
GO:0043085positive regulation of catalytic activityIEA
GO:0043375CD8-positive, alpha-beta T cell lineage commitmentIEA
GO:0043496regulation of protein homodimerization activityIDA
GO:0043497regulation of protein heterodimerization activityIDA
GO:0043524negative regulation of neuron apoptotic processIDA
GO:0043583ear developmentIEA
GO:0045069regulation of viral genome replicationIEA
GO:0045087innate immune responseTAS
GO:0045636positive regulation of melanocyte differentiationIEA
GO:0045930negative regulation of mitotic cell cycleIEA
GO:0046671negative regulation of retinal cell programmed cell deathIEA
GO:0046902regulation of mitochondrial membrane permeabilityISS
GO:0048041focal adhesion assemblyIEA
GO:0048536spleen developmentIEA
GO:0048538thymus developmentIEA
GO:0048546digestive tract morphogenesisIEA
GO:0048589developmental growthIEA
GO:0048599oocyte developmentIEA
GO:0048743positive regulation of skeletal muscle fiber developmentIEA
GO:0048753pigment granule organizationIEA
GO:0048873homeostasis of number of cells within a tissueIEA
GO:0050853B cell receptor signaling pathwayIMP
GO:0051384response to glucocorticoidIEA
GO:0051402neuron apoptotic processTAS
GO:0051607defense response to virusIDA
GO:0051881regulation of mitochondrial membrane potentialISS
GO:0051902negative regulation of mitochondrial depolarizationTAS
GO:0051924regulation of calcium ion transportIDA
GO:0055085transmembrane transportIDA
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIDA
GO:0071310cellular response to organic substanceIEA
GO:0071456cellular response to hypoxiaIEA
GO:0072593reactive oxygen species metabolic processIEA
GO:0097192extrinsic apoptotic signaling pathway in absence of ligandIEA
GO:0097193intrinsic apoptotic signaling pathwayTAS
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS
GO:2000134negative regulation of G1/S transition of mitotic cell cycleIEA
GO:2000811negative regulation of anoikisIMP
GO:2001234negative regulation of apoptotic signaling pathwayIMP
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIGI
GO:2001243negative regulation of intrinsic apoptotic signaling pathwayIDA
GO:2001244positive regulation of intrinsic apoptotic signaling pathwayTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0005741mitochondrial outer membraneIDA
GO:0005741mitochondrial outer membraneTAS
GO:0005783endoplasmic reticulumIDA
GO:0005789endoplasmic reticulum membraneIEA
GO:0005829cytosolIEA
GO:0016020membraneIDA
GO:0031965nuclear membraneIDA
GO:0043209myelin sheathIEA
GO:0046930pore complexIDA
Function
IDNameEvidence
GO:0002020protease bindingIDA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIEA
GO:0015267channel activityIDA
GO:0016248channel inhibitor activityIDA
GO:0031625ubiquitin protein ligase bindingIPI
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0043565sequence-specific DNA bindingIDA
GO:0046982protein heterodimerization activityIPI
GO:0051434BH3 domain bindingIPI
GO:0051721protein phosphatase 2A bindingIEA
GeneCards BCL2
UniProt P10415
MIM 151430
Ensembl ENSG00000171791
HGNC 990
HPRD 01045

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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