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RET ret proto-oncogene [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_020630 Homo sapiens ret proto-oncogene (RET), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_020975 Homo sapiens ret proto-oncogene (RET), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol RET
Entrez Gene ID 5979
Full Name ret proto-oncogene
Synonyms CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q11.2

Summary This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164761

Multiple endocrine neoplasia IIA, 171400 (3); Medullary thyroid

mRNA Protein Product Sequence Price Select
NM_020630, 126273513 NP_065681, 10862701 proto-oncogene tyrosine-protein kinase receptor Ret isoform c ORF Sequence $1500.00
NM_020975, 126273511 NP_066124, 10862703 proto-oncogene tyrosine-protein kinase receptor Ret isoform a ORF Sequence $1500.00
KEGG
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa04144Endocytosis
WikiPathways
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
ret_pathwaySignaling events regulated by Ret tyrosine kinase
Homo sapiens (human)RETNP_066124.1
Pan troglodytes (chimpanzee)RETXP_003312612.1
Macaca mulatta (Rhesus monkey)RETXP_002805672.1
Canis lupus familiaris (dog)RETNP_001184028.1
Bos taurus (cattle)RETNP_001178412.1
Mus musculus (house mouse)RetNP_033076.2
Rattus norvegicus (Norway rat)RetNP_036775.2
Gallus gallus (chicken)RETNP_990521.1
Danio rerio (zebrafish)retNP_858048.2
GeneCards RET
PDB 2X2K, 2IVU, 2X2M, 2IVS, 1XPD, 2IVT, 2X2U, 2IVV, 2X2L
UniProt Q9BTX6, P07949
MIM 164761
Ensembl ENSG00000165731
HGNC 9967
HPRD 01266

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant



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