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RET ret proto-oncogene [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_020630 Homo sapiens ret proto-oncogene (RET), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_020975 Homo sapiens ret proto-oncogene (RET), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006717936 PREDICTED: Homo sapiens ret proto-oncogene (RET), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol RET
Entrez Gene ID 5979
Full Name ret proto-oncogene
Synonyms CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q11.2

Summary This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164761

Multiple endocrine neoplasia IIA, 171400 (3); Medullary thyroid

mRNA Protein Product Sequence Price Select
NM_020630, 126273513 NP_065681, 10862701 proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor ORF Sequence $1500.00
NM_020975, 126273511 NP_066124, 10862703 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor ORF Sequence $1500.00
XM_006717936, 578819677 XP_006717999, 578819678 proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 ORF Sequence $1500.00
KEGG
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa04144Endocytosis
WikiPathways
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
ret_pathwaySignaling events regulated by Ret tyrosine kinase
Homo sapiens (human)RETNP_066124.1
Pan troglodytes (chimpanzee)RETXP_003312612.1
Macaca mulatta (Rhesus monkey)RETXP_002805672.1
Canis lupus familiaris (dog)RETNP_001184028.1
Bos taurus (cattle)RETNP_001178412.1
Mus musculus (house mouse)RetNP_033076.2
Rattus norvegicus (Norway rat)RetNP_036775.2
Gallus gallus (chicken)RETNP_990521.1
Danio rerio (zebrafish)retNP_858048.2
Xenopus (Silurana) tropicalis (western clawed frog)retXP_002933941.2
Process
IDNameEvidence
GO:0000165MAPK cascadeIEA
GO:0001657ureteric bud developmentIEA
GO:0001755neural crest cell migrationIEA
GO:0001838embryonic epithelial tube formationIEA
GO:0006468protein phosphorylationTAS
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIMP
GO:0007156homophilic cell adhesionIEA
GO:0007158neuron cell-cell adhesionIMP
GO:0007165signal transductionTAS
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA
GO:0007497posterior midgut developmentTAS
GO:0010976positive regulation of neuron projection developmentIMP
GO:0014042positive regulation of neuron maturationIEA
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0018108peptidyl-tyrosine phosphorylationTAS
GO:0030155regulation of cell adhesionIDA
GO:0030335positive regulation of cell migrationIDA
GO:0033619membrane protein proteolysisIDA
GO:0033630positive regulation of cell adhesion mediated by integrinIDA
GO:0035799ureter maturationIEA
GO:0042493response to drugIEA
GO:0042551neuron maturationIEA
GO:0045793positive regulation of cell sizeIEA
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0048265response to painISS
GO:0048484enteric nervous system developmentIEA
GO:0050770regulation of axonogenesisIEA
GO:0060041retina development in camera-type eyeIEA
GO:0060384innervationIEA
GO:0061146Peyer's patch morphogenesisISS
GO:0071300cellular response to retinoic acidIMP
GO:0072300positive regulation of metanephric glomerulus developmentISS
GO:0097021lymphocyte migration into lymphoid organsISS
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIMP
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligandTAS
Component
IDNameEvidence
GO:0005887integral component of plasma membraneIDA
GO:0010008endosome membraneIDA
GO:0043235receptor complexIDA
GO:0045121membrane raftIEA
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityTAS
GO:0004714transmembrane receptor protein tyrosine kinase activityIEA
GO:0004872receptor activityTAS
GO:0005509calcium ion bindingIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GeneCards RET
UniProt Q9BTX6, P07949
Vega OTTHUMG00000018024
MIM 164761
Ensembl ENSG00000165731
HGNC 9967
HPRD 01266

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RET gene?

The RET gene provides instructions for producing a protein that is involved in signaling within cells. This protein appears to be essential for the normal development of several kinds of nerve cells, including nerves in the intestine (enteric neurons) and the portion of the nervous system that controls involuntary body functions such as heart rate (the autonomic nervous system). The RET protein is also necessary for normal kidney development and the production of sperm (spermatogenesis).

The RET protein spans the cell membrane, so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning of the protein allows it to interact with specific factors outside the cell and to receive signals that help the cell respond to its environment. When molecules that stimulate growth and development (growth factors) attach to the RET protein, a complex cascade of chemical reactions inside the cell is triggered. These reactions instruct the cell to undergo certain changes, such as dividing or maturing to take on specialized functions.

Interactant

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