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HPSE2 heparanase 2 (inactive) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001166244 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001166245 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001166246 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_021828 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006717937 PREDICTED: Homo sapiens heparanase 2 (HPSE2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol HPSE2
Entrez Gene ID 60495
Full Name heparanase 2 (inactive)
Synonyms HPA2, HPR2, UFS, UFS1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

MIM: 613469

Urofacial syndrome, 236730 (3)

mRNA Protein Product Sequence Price Select
NM_001166244, 261878502 NP_001159716, 261878503 inactive heparanase-2 isoform 2 ORF Sequence $550.00
NM_001166245, 261878504 NP_001159717, 261878505 inactive heparanase-2 isoform 3 ORF Sequence $550.00
NM_001166246, 261878506 NP_001159718, 261878507 inactive heparanase-2 isoform 4 ORF Sequence $550.00
NM_021828, 261878500 NP_068600, 261878501 inactive heparanase-2 isoform 1 ORF Sequence $700.00
XM_006717937, 578819679 XP_006718000, 578819680 inactive heparanase-2 isoform X1 ORF Sequence $550.00
hsa00531Glycosaminoglycan degradation
hsa_M00078Heparan sulfate degradation
hsa05205Proteoglycans in cancer
REACT_474Metabolism of carbohydrates
REACT_147749MPS IIID - Sanfilippo syndrome D
REACT_147825MPS IV - Morquio syndrome A
REACT_147719MPS VI - Maroteaux-Lamy syndrome
REACT_147753MPS IIIA - Sanfilippo syndrome A
REACT_147739MPS IX - Natowicz syndrome
REACT_147860MPS IIIC - Sanfilippo syndrome C
REACT_147734MPS II - Hunter syndrome
REACT_147788MPS IIIB - Sanfilippo syndrome B
REACT_147759MPS VII - Sly syndrome
REACT_147798MPS IV - Morquio syndrome B
REACT_147857MPS I - Hurler syndrome
REACT_121315Glycosaminoglycan metabolism
REACT_121314Heparan sulfate/heparin (HS-GAG) metabolism
REACT_120752HS-GAG degradation
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)HPSE2NP_068600.4
Pan troglodytes (chimpanzee)HPSE2XP_001166372.1
Canis lupus familiaris (dog)HPSE2XP_850311.1
Bos taurus (cattle)HPSE2XP_005225719.1
Mus musculus (house mouse)Hpse2NP_001074726.1
Rattus norvegicus (Norway rat)Hpse2NP_001129234.1
Gallus gallus (chicken)HPSE2XP_421704.2
Danio rerio (zebrafish)hpse2XP_691045.2
Xenopus (Silurana) tropicalis (western clawed frog)hpse2XP_002937229.1
GO:0005975carbohydrate metabolic processTAS
GO:0006027glycosaminoglycan catabolic processTAS
GO:0030203glycosaminoglycan metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0005578proteinaceous extracellular matrixIDA
GO:0005886plasma membraneTAS
GO:0030305heparanase activityIDA
GO:0030305heparanase activityTAS
GO:0043395heparan sulfate proteoglycan bindingIDA
GeneCards HPSE2
UniProt Q8WWQ2, Q2M1H9
MIM 613469
HGNC 18374
HPRD 13669

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the HPSE2 gene?

The HPSE2 gene provides instructions for making a protein called heparanase 2. Little is known about this protein, but its structure is similar to that of another protein called heparanase 1. Heparanase 1 is an enzyme that splits (cleaves) molecules called heparan sulfate proteoglycans (HSPGs) by removing the heparan sulfate portion (the side chain).

HSPGs are important parts of the lattice of proteins and other molecules outside the cell (extracellular matrix) and of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Cleavage of HSPGs by heparanase 1 may lead to changes in the basement membrane or extracellular matrix that allow cell movement or release of substances from the cell. The specific function of the heparanase 2 enzyme is not well understood, but studies suggest that it may block the action of heparanase 1.


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