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ALX4 ALX homeobox 4 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_021926 Homo sapiens ALX homeobox 4 (ALX4), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol ALX4
Entrez Gene ID 60529
Full Name ALX homeobox 4
Synonyms FND2, KIAA1788
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009].

MIM: 605420

Parietal foramina 2, 609597 (3); Frontonasal dysplasia 2, 613451 (3)

mRNA Protein Product Sequence Price Select
NM_021926, 261245049 NP_068745, 55743092 homeobox protein aristaless-like 4 ORF Sequence $400.00
Homo sapiens (human)ALX4NP_068745.2
Pan troglodytes (chimpanzee)ALX4XP_521895.3
Macaca mulatta (Rhesus monkey)ALX4XP_001113643.1
Canis lupus familiaris (dog)ALX4XP_850737.1
Bos taurus (cattle)ALX4NP_001025475.1
Mus musculus (house mouse)Alx4NP_031468.1
Rattus norvegicus (Norway rat)Alx4NP_001100023.1
Gallus gallus (chicken)ALX4NP_989493.1
Danio rerio (zebrafish)alx4aXP_001340966.1
Danio rerio (zebrafish)alx4bNP_001082826.1
GeneCards ALX4
UniProt Q9H161
MIM 605420
Ensembl ENSG00000052850
HGNC 450
HPRD 05661

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information


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