• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


ALX4 ALX homeobox 4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22706 NM_021926 Homo sapiens ALX homeobox 4 (ALX4), mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22706C NM_021926 Homo sapiens ALX homeobox 4 (ALX4), mRNA. Customized vector On-demand TBD $269.00

*Business Day

Related Services

Gene Symbol ALX4
Entrez Gene ID 60529
Full Name ALX homeobox 4
Synonyms CRS5, FND2
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p11.2

Summary This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009].
Disorder

MIM: 605420

Parietal foramina 2, 609597 (3); Frontonasal dysplasia 2, 613451 (3)

mRNA Protein Product Sequence Price Select
NM_021926, 261245049 NP_068745, 55743092 homeobox protein aristaless-like 4 ORF Sequence $400.00
Homo sapiens (human)ALX4NP_068745.2
Pan troglodytes (chimpanzee)ALX4XP_521895.3
Macaca mulatta (Rhesus monkey)ALX4XP_001113643.1
Canis lupus familiaris (dog)ALX4XP_850737.1
Bos taurus (cattle)ALX4NP_001025475.1
Mus musculus (house mouse)Alx4NP_031468.1
Rattus norvegicus (Norway rat)Alx4NP_001100023.1
Gallus gallus (chicken)ALX4NP_989493.1
Danio rerio (zebrafish)alx4bNP_001082826.1
Danio rerio (zebrafish)alx4aXP_001340966.1
Xenopus (Silurana) tropicalis (western clawed frog)alx4XP_002937332.2
Process
IDNameEvidence
GO:0001501skeletal system developmentNAS
GO:0001942hair follicle developmentIMP
GO:0006351transcription, DNA-templatedIEA
GO:0007517muscle organ developmentIEA
GO:0009791post-embryonic developmentIEA
GO:0009952anterior/posterior pattern specificationIEA
GO:0035115embryonic forelimb morphogenesisIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0042733embryonic digit morphogenesisIEA
GO:0042981regulation of apoptotic processIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048565digestive tract developmentIEA
GO:0048704embryonic skeletal system morphogenesisIEA
GO:0060021palate developmentIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005667transcription factor complexIEA
Function
IDNameEvidence
GO:0003677DNA bindingNAS
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIEA
GO:0046982protein heterodimerization activityIEA
GO:0071837HMG box domain bindingIEA
GeneCards ALX4
PDB 2M0C
UniProt Q9H161
Vega OTTHUMG00000166557
MIM 605420
Ensembl ENSG00000052850
HGNC 450
HPRD 05661

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.