• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


BCR breakpoint cluster region [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25516 NM_021574 Homo sapiens breakpoint cluster region (BCR), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu25583 NM_004327 Homo sapiens breakpoint cluster region (BCR), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu25516C NM_021574 Homo sapiens breakpoint cluster region (BCR), transcript variant 2, mRNA. Customized vector On-demand TBD TBD
OHu25583C NM_004327 Homo sapiens breakpoint cluster region (BCR), transcript variant 1, mRNA. Customized vector On-demand TBD TBD

*Business Day

Related Services

Gene Symbol BCR
Entrez Gene ID 613
Full Name breakpoint cluster region
Synonyms ALL, BCR1, CML, D22S11, D22S662, PHL
General protein information
Preferred Names
breakpoint cluster region protein
Names
breakpoint cluster region protein
BCR/FGFR1 chimera protein
FGFR1/BCR chimera protein
renal carcinoma antigen NY-REN-26
NP_004318.3
NP_067585.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q11.23

Summary A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 151410

Leukemia, chronic myeloid, 608232 (3); Leukemia, acute lymphocytic,

mRNA Protein Product Sequence Price Select
NM_004327, 82546842 NP_004318, 82546843 breakpoint cluster region protein isoform 1 ORF Sequence $1500.00
NM_021574, 82546844 NP_067585, 82546845 breakpoint cluster region protein isoform 2 ORF Sequence $1500.00
KEGG
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
Pathway Interaction Database
rhoa_reg_pathwayRegulation of RhoA activity
rac1_reg_pathwayRegulation of RAC1 activity
Reactome
REACT_11044Signaling by Rho GTPases
REACT_11051Rho GTPase cycle
REACT_111102Signal Transduction
REACT_116125Disease
REACT_120736Signaling by FGFR in disease
REACT_121141Signaling by FGFR1 fusion mutants
REACT_121398Signaling by FGFR mutants
REACT_120999Signaling by FGFR1 mutants
Homo sapiens (human)BCRNP_004318.3
Pan troglodytes (chimpanzee)BCRXP_003317181.1
Macaca mulatta (Rhesus monkey)BCRXP_002798337.1
Canis lupus familiaris (dog)BCRXP_848654.2
Mus musculus (house mouse)BcrNP_001074881.1
Rattus norvegicus (Norway rat)BcrXP_228091.6
Gallus gallus (chicken)BCRXP_415244.3
Danio rerio (zebrafish)bcrXP_005161278.1
Xenopus (Silurana) tropicalis (western clawed frog)bcrNP_001123792.1
Process
IDNameEvidence
GO:0006468protein phosphorylationTAS
GO:0007165signal transductionTAS
GO:0007264small GTPase mediated signal transductionTAS
GO:0007420brain developmentIEA
GO:0018108peptidyl-tyrosine phosphorylationTAS
GO:0030036actin cytoskeleton organizationIEA
GO:0030336negative regulation of cell migrationIEA
GO:0032496response to lipopolysaccharideIEA
GO:0032855positive regulation of Rac GTPase activityIEA
GO:0042472inner ear morphogenesisIEA
GO:0043314negative regulation of neutrophil degranulationIEA
GO:0046777protein autophosphorylationIEA
GO:0048008platelet-derived growth factor receptor signaling pathwayIEA
GO:0050728negative regulation of inflammatory responseIEA
GO:0050766positive regulation of phagocytosisIEA
GO:0050885neuromuscular process controlling balanceIEA
GO:0051056regulation of small GTPase mediated signal transductionTAS
GO:0051726regulation of cell cycleIEA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0005886plasma membraneIEA
GO:0016020membraneIDA
GO:0043234protein complexIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityIEA
GO:0004713protein tyrosine kinase activityTAS
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA
GO:0005096GTPase activator activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0016301kinase activityTAS
GO:0019899enzyme bindingIEA
GO:0030675Rac GTPase activator activityIEA
GeneCards BCR
UniProt P11274
Vega OTTHUMG00000150655
MIM 151410
Ensembl ENSG00000186716
HGNC 1014
HPRD 01044

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.