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BCR breakpoint cluster region [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004327 Homo sapiens breakpoint cluster region (BCR), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_021574 Homo sapiens breakpoint cluster region (BCR), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol BCR
Entrez Gene ID 613
Full Name breakpoint cluster region
Synonyms ALL, BCR1, CML, D22S11, D22S662, FLJ16453, PHL
Gene Type protein-coding
Organism Homo sapiens (human)



Summary A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 151410

Leukemia, chronic myeloid, 608232 (3); Leukemia, acute lymphocytic,

mRNA Protein Product Sequence Price Select
NM_004327, 82546842 NP_004318, 82546843 breakpoint cluster region protein isoform 1 ORF Sequence $1500.00
NM_021574, 82546844 NP_067585, 82546845 breakpoint cluster region protein isoform 2 ORF Sequence $1500.00
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
Pathway Interaction Database
rhoa_reg_pathwayRegulation of RhoA activity
rac1_reg_pathwayRegulation of RAC1 activity
REACT_11051Rho GTPase cycle
REACT_11044Signaling by Rho GTPases
REACT_121141Signaling by FGFR1 fusion mutants
REACT_121398Signaling by FGFR mutants
REACT_111102Signal Transduction
REACT_120736Signaling by FGFR in disease
REACT_120999Signaling by FGFR1 mutants
Homo sapiens (human)BCRNP_004318.3
Pan troglodytes (chimpanzee)BCRXP_003317181.1
Macaca mulatta (Rhesus monkey)BCRXP_002798337.1
Canis lupus familiaris (dog)BCRXP_848654.2
Mus musculus (house mouse)BcrNP_001074881.1
Rattus norvegicus (Norway rat)BcrXP_228091.5
Gallus gallus (chicken)BCRXP_415244.3
Danio rerio (zebrafish)bcrXP_002665983.1
GeneCards BCR
UniProt P11274
MIM 151410
Ensembl ENSG00000186716
HGNC 1014
HPRD 01044

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
breakpoint cluster region protein
breakpoint cluster region protein
BCR/FGFR1 chimera protein
FGFR1/BCR chimera protein
renal carcinoma antigen NY-REN-26


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