RPS10 ribosomal protein S10 [Homo sapiens (human)]
| Gene Symbol | RPS10 |
| Entrez Gene ID | 6204 |
| Full Name | ribosomal protein S10 |
| Synonyms | DBA9, MGC88819, S10 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p21.31 |
| Summary | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3). |
| Disorder | MIM: 603632 Diamond-Blackfan anemia 9, 613308 (3) |
| mRNA | NM_001014, 322303055 |
| Protein | NP_001005, 4506679 |
| Product | 40S ribosomal protein S10 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001203245, 323276698 |
| Protein | NP_001190174, 322303127 |
| Product | 40S ribosomal protein S10 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001204091, 323276699 |
| Protein | NP_001191020, 323276700 |
| Product | 40S ribosomal protein S10 |
| RefSeq Status | REVIEWED |
| hsa03010 | Ribosome |
WikiPathways
| WP477 | Cytoplasmic Ribosomal Proteins |
Reactome
| REACT_15380 | Diabetes pathways |
| REACT_2159 | Eukaryotic Translation Initiation |
| REACT_6145 | Influenza Life Cycle |
| REACT_1477 | Eukaryotic Translation Elongation |
| REACT_1797 | Formation of a pool of free 40S subunits |
| REACT_9491 | Viral mRNA Translation |
| REACT_79 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REACT_15550 | Insulin Synthesis and Processing |
| REACT_1079 | Formation of the ternary complex, and subsequently, the 43S complex |
| REACT_17015 | Metabolism of proteins |
| REACT_1979 | Translation initiation complex formation |
| REACT_13819 | Regulation of gene expression in beta cells |
| REACT_1986 | Eukaryotic Translation Termination |
| REACT_2085 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REACT_71 | Gene Expression |
| REACT_1404 | Peptide chain elongation |
| REACT_1258 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REACT_6167 | Influenza Infection |
| REACT_1014 | Translation |
| REACT_931 | Ribosomal scanning and start codon recognition |
| REACT_2099 | Cap-dependent Translation Initiation |
| REACT_6152 | Influenza Viral RNA Transcription and Replication |
| REACT_13698 | Regulation of beta-cell development |
| Homo sapiens (human) | RPS10 | NP_001005.1 |
| Pan troglodytes (chimpanzee) | RPS10 | XP_001171673.1 |
| Canis lupus familiaris (dog) | RPS10 | XP_537583.2 |
| Bos taurus (cattle) | RPS10 | NP_001029888.1 |
| Mus musculus (house mouse) | Rps10 | NP_080239.1 |
| Rattus norvegicus (Norway rat) | Rps10 | NP_112371.1 |
| Gallus gallus (chicken) | RPS10 | XP_418029.1 |
| Danio rerio (zebrafish) | rps10 | NP_957440.1 |
| Drosophila melanogaster (fruit fly) | RpS10b | NP_608324.1 |
| Caenorhabditis elegans | rps-10 | NP_491398.1 |
| Arabidopsis thaliana (thale cress) | AT5G41520 | NP_198967.1 |
| ID | Name | Evidence |
| GO:0006412 | translation | IC |
| GO:0006412 | translation | TAS |
| GO:0006414 | translational elongation | EXP |
| GO:0006415 | translational termination | TAS |
| GO:0010467 | gene expression | TAS |
| GO:0016032 | viral reproduction | TAS |
| GO:0019058 | viral infectious cycle | TAS |
| GO:0019083 | viral transcription | TAS |
| GO:0031018 | endocrine pancreas development | TAS |
| GO:0044267 | cellular protein metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005730 | nucleolus | IDA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0005840 | ribosome | NAS |
| GO:0022627 | cytosolic small ribosomal subunit | IDA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |