RPS13 ribosomal protein S13 [Homo sapiens (human)]
| Gene Symbol | RPS13 |
| Entrez Gene ID | 6207 |
| Full Name | ribosomal protein S13 |
| Synonyms | S13 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
11 11p15 |
| Summary | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]. |
| Disorder | MIM: 180476 |
| mRNA | NM_001017, 14591910 |
| Protein | NP_001008, 4506685 |
| Product | 40S ribosomal protein S13 |
| RefSeq Status | REVIEWED |
| hsa03010 | Ribosome |
WikiPathways
| WP477 | Cytoplasmic Ribosomal Proteins |
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
Reactome
| REACT_1079 | Formation of the ternary complex, and subsequently, the 43S complex |
| REACT_15380 | Diabetes pathways |
| REACT_1477 | Eukaryotic Translation Elongation |
| REACT_2159 | Eukaryotic Translation Initiation |
| REACT_6145 | Influenza Life Cycle |
| REACT_1797 | Formation of a pool of free 40S subunits |
| REACT_1986 | Eukaryotic Translation Termination |
| REACT_79 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REACT_13819 | Regulation of gene expression in beta cells |
| REACT_17015 | Metabolism of proteins |
| REACT_1979 | Translation initiation complex formation |
| REACT_2085 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REACT_71 | Gene Expression |
| REACT_9491 | Viral mRNA Translation |
| REACT_1258 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REACT_1014 | Translation |
| REACT_6167 | Influenza Infection |
| REACT_931 | Ribosomal scanning and start codon recognition |
| REACT_1404 | Peptide chain elongation |
| REACT_2099 | Cap-dependent Translation Initiation |
| REACT_15550 | Insulin Synthesis and Processing |
| REACT_13698 | Regulation of beta-cell development |
| REACT_6152 | Influenza Viral RNA Transcription and Replication |
| Homo sapiens (human) | RPS13 | NP_001008.1 |
| Pan troglodytes (chimpanzee) | RPS13 | XP_508306.1 |
| Canis lupus familiaris (dog) | RPS13 | XP_852037.1 |
| Bos taurus (cattle) | RPS13 | NP_001020513.1 |
| Rattus norvegicus (Norway rat) | Rps13 | NP_569116.1 |
| Rattus norvegicus (Norway rat) | LOC684988 | XP_001053043.1 |
| Gallus gallus (chicken) | RPS13 | NP_001001783.1 |
| Danio rerio (zebrafish) | rps13 | NP_001002079.1 |
| Drosophila melanogaster (fruit fly) | RpS13 | NP_001033885.1 |
| Caenorhabditis elegans | rps-13 | NP_498393.1 |
| Arabidopsis thaliana (thale cress) | ATRPS13A | NP_567151.1 |
| Arabidopsis thaliana (thale cress) | AT3G60770 | NP_567104.1 |
| ID | Name | Evidence |
| GO:0006412 | translation | IC |
| GO:0006412 | translation | TAS |
| GO:0006414 | translational elongation | EXP |
| GO:0006415 | translational termination | TAS |
| GO:0010467 | gene expression | TAS |
| GO:0016032 | viral reproduction | TAS |
| GO:0019058 | viral infectious cycle | TAS |
| GO:0019083 | viral transcription | TAS |
| GO:0031018 | endocrine pancreas development | TAS |
| GO:0033119 | negative regulation of RNA splicing | IDA |
| GO:0044267 | cellular protein metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005730 | nucleolus | IDA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0005840 | ribosome | NAS |
| GO:0022627 | cytosolic small ribosomal subunit | IDA |
Function
| ID | Name | Evidence |
| GO:0003729 | mRNA binding | IDA |
| GO:0003735 | structural constituent of ribosome | IEA |
| GO:0005515 | protein binding | IPI |
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