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RPS17 ribosomal protein S17 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001021 Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Gene Symbol RPS17
Entrez Gene ID 6218
Full Name ribosomal protein S17
Synonyms DBA4, RPS17L, RPS17L1, RPS17L2, S17
General protein information
Preferred Names
40S ribosomal protein S17
40S ribosomal protein S17
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014].

MIM: 180472

Diamond-Blackfan anemia 4, 612527 (3)

mRNA Protein Product Sequence Price Select
NM_001021, 607344306 NP_001012, 4506693 40S ribosomal protein S17 ORF Sequence $99.00
hsa_M00177Ribosome, eukaryotes
WP477Cytoplasmic Ribosomal Proteins
REACT_71Gene Expression
REACT_2159Eukaryotic Translation Initiation
REACT_1404Peptide chain elongation
REACT_1258Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
REACT_1979Translation initiation complex formation
REACT_2085GTP hydrolysis and joining of the 60S ribosomal subunit
REACT_1079Formation of the ternary complex, and subsequently, the 43S complex
REACT_1477Eukaryotic Translation Elongation
REACT_2099Cap-dependent Translation Initiation
REACT_931Ribosomal scanning and start codon recognition
REACT_1797Formation of a pool of free 40S subunits
REACT_6145Influenza Life Cycle
REACT_9491Viral mRNA Translation
REACT_6152Influenza Viral RNA Transcription and Replication
REACT_1986Eukaryotic Translation Termination
REACT_6167Influenza Infection
REACT_17015Metabolism of proteins
REACT_79L13a-mediated translational silencing of Ceruloplasmin expression
REACT_75768Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
REACT_75822Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
REACT_75886Nonsense-Mediated Decay (NMD)
REACT_115902SRP-dependent cotranslational protein targeting to membrane
Homo sapiens (human)RPS17NP_001012.1
Pan troglodytes (chimpanzee)RPS17XP_525570.2
Macaca mulatta (Rhesus monkey)RPS17LXP_002804971.1
Canis lupus familiaris (dog)RPS17NP_001003099.1
Bos taurus (cattle)RPS17NP_001092680.1
Mus musculus (house mouse)Rps17NP_033118.1
Gallus gallus (chicken)RPS17LNP_989548.1
Danio rerio (zebrafish)zgc:114188NP_001013473.1
Caenorhabditis elegansrps-17NP_491795.1
Arabidopsis thaliana (thale cress)AT3G10610NP_187672.1
Arabidopsis thaliana (thale cress)AT5G04800NP_001031834.1
Arabidopsis thaliana (thale cress)AT2G04390NP_178520.1
Arabidopsis thaliana (thale cress)AT2G05220NP_565320.1
Xenopus (Silurana) tropicalis (western clawed frog)rps17XP_002938919.1
GO:0000028ribosomal small subunit assemblyIBA
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTAS
GO:0006364rRNA processingIMP
GO:0006413translational initiationNAS
GO:0006413translational initiationTAS
GO:0006414translational elongationIBA
GO:0006414translational elongationTAS
GO:0006415translational terminationTAS
GO:0006614SRP-dependent cotranslational protein targeting to membraneTAS
GO:0010467gene expressionTAS
GO:0016032viral processTAS
GO:0016070RNA metabolic processTAS
GO:0016071mRNA metabolic processTAS
GO:0019058viral life cycleTAS
GO:0019083viral transcriptionTAS
GO:0034101erythrocyte homeostasisIMP
GO:0042274ribosomal small subunit biogenesisIMP
GO:0044267cellular protein metabolic processTAS
GO:0022627cytosolic small ribosomal subunitIBA
GO:0022627cytosolic small ribosomal subunitIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0003735structural constituent of ribosomeNAS
GO:0044822poly(A) RNA bindingIDA
GeneCards RPS17
UniProt P0CW22, P08708
Vega OTTHUMG00000172543
MIM 180472
Ensembl ENSG00000184779
HGNC 10397
HPRD 01600

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RPS17 gene?

The RPS17 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Ribosomes process the cell's genetic instructions to create proteins.

Each ribosome is made up of two parts (subunits) called the large and small subunits. The protein produced from the RPS17 gene is among those found in the small subunit.

The specific functions of the RPS17 protein and the other ribosomal proteins within these subunits are unclear. Some ribosomal proteins are involved in the assembly or stability of ribosomes. Others help carry out the ribosome's main function of building new proteins. Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis).


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