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Sequence in raw or FASTA format:


Blast Method:


SAA1 serum amyloid A1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000331 Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001178006 Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_199161 Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Gene Symbol SAA1
Entrez Gene ID 6288
Full Name serum amyloid A1
Synonyms PIG4, SAA, SAA2, TP53I4
General protein information
Preferred Names
serum amyloid A-1 protein
serum amyloid A-1 protein
serum amyloid A protein
tumor protein p53 inducible protein 4
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012].

MIM: 104750

mRNA Protein Product Sequence Price Select
NM_000331, 295821191 NP_000322, 40316912 serum amyloid A-1 protein preproprotein ORF Sequence $99.00
NM_001178006, 295821192 NP_001171477, 295821193 serum amyloid A-1 protein preproprotein ORF Sequence $99.00
NM_199161, 295821190 NP_954630, 40316910 serum amyloid A-1 protein preproprotein ORF Sequence $99.00
WP15Selenium Pathway
WP176Folate Metabolism
WP1533Vitamin B12 Metabolism
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_18283G alpha (q) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6809MyD88-independent cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_6966Toll-Like Receptors Cascades
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_21340GPCR ligand binding
REACT_21264Formyl peptide receptors bind formyl peptides and many other ligands
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_24969TRAF6 mediated NF-kB activation
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_111102Signal Transduction
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_163679Scavenging by Class B Receptors
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
Homo sapiens (human)SAA1NP_000322.2
Pan troglodytes (chimpanzee)SAA1XP_003951896.1
Macaca mulatta (Rhesus monkey)SAA1XP_001086366.1
Macaca mulatta (Rhesus monkey)LOC694944XP_001086477.1
Canis lupus familiaris (dog)LOC100684663XP_003432981.1
Canis lupus familiaris (dog)LOC102155886XP_005633785.1
Canis lupus familiaris (dog)LOC476879XP_534081.1
Bos taurus (cattle)SAA3NP_851359.2
Bos taurus (cattle)SAA2NP_001068728.1
Bos taurus (cattle)M-SAA3.2NP_001229502.1
Mus musculus (house mouse)Saa1NP_033143.1
Mus musculus (house mouse)Saa2NP_035444.1
Danio rerio (zebrafish)saaNP_001005599.1
GO:0006953acute-phase responseNAS
GO:0007204positive regulation of cytosolic calcium ion concentrationIDA
GO:0007204positive regulation of cytosolic calcium ion concentrationNAS
GO:0030168platelet activationNAS
GO:0030593neutrophil chemotaxisNAS
GO:0045087innate immune responseTAS
GO:0045785positive regulation of cell adhesionIDA
GO:0045785positive regulation of cell adhesionNAS
GO:0048246macrophage chemotaxisIDA
GO:0048247lymphocyte chemotaxisIDA
GO:0050708regulation of protein secretionNAS
GO:0050715positive regulation of cytokine secretionIDA
GO:0050716positive regulation of interleukin-1 secretionNAS
GO:0050728negative regulation of inflammatory responseNAS
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0034364high-density lipoprotein particleIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0071682endocytic vesicle lumenTAS
GO:0001664G-protein coupled receptor bindingIDA
GO:0008201heparin bindingIEA
GeneCards SAA1
PDB 4IP8, 4IP9
UniProt P0DJI8
Vega OTTHUMG00000166147
MIM 104750
Ensembl ENSG00000173432
HGNC 10513
HPRD 00097

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SAA1 gene?

The SAA1 gene provides instructions for making a protein called serum amyloid A1. This protein is made primarily in the liver and circulates in low levels in the blood. Although its function is not fully understood, serum amyloid A1 appears to play a role in the immune system. Serum amyloid A1 may help repair damaged tissues, act as an antibacterial agent, and signal the migration of germ-fighting cells to sites of infection.

Levels of this protein increase in the blood and other tissues under conditions of inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. When this has been accomplished, the body stops the inflammatory response to prevent damage to its own cells and tissues.

There are three versions of the serum amyloid A1 protein, known as alpha, beta, and gamma, which differ by one or two protein building blocks (amino acids). The frequency of these variants differs across populations. In Caucasian populations, the alpha version predominates and gamma is rare. In the Japanese population, however, the three versions appear almost equally.


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