Sequence in raw or FASTA format:
SCN10A sodium channel, voltage-gated, type X, alpha subunit [Homo sapiens (human)]
| Gene Symbol | SCN10A |
| Entrez Gene ID | 6336 |
| Full Name | sodium channel, voltage-gated, type X, alpha subunit |
| Synonyms | Nav1.8, PN3, SNS, hPN3 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
3 3p22.2 |
| Summary | Voltage-gated sodium channels are integral membrane glycoproteins that are responsible for the initial rising phase of action in most excitable cells. They are composed of a large alpha subunit that may be associated with one or more smaller beta subunits. Sodium channels can be differentiated by their primary structure, kinetics, and relative sensitivity to the neurotoxin tetrodotoxin (TTX). Sodium channels, particularly those with TTX-resistant currents, have been found to accumulate in the region of peripheral nerve injury and may be important in chronic pain. SCN10A encodes a TTX-resistant channel that is restricted to the peripheral sensory nervous system (Rabert et al., 1998 [PubMed 9839820]).[supplied by OMIM]. |
| Disorder | MIM: 604427 |
| mRNA | NM_006514, 110835709 |
| Protein | NP_006505, 110835710 |
| Product | sodium channel protein type 10 subunit alpha |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | SCN10A | NP_006505.2 |
| Pan troglodytes (chimpanzee) | SCN10A | XP_516372.2 |
| Canis lupus familiaris (dog) | SCN10A | XP_855575.1 |
| Mus musculus (house mouse) | Scn10a | NP_033160.2 |
| Rattus norvegicus (Norway rat) | Scn10a | NP_058943.1 |
| ID | Name | Evidence |
| GO:0006811 | ion transport | IEA |
| GO:0006814 | sodium ion transport | TAS |
| GO:0007600 | sensory perception | TAS |
| GO:0055085 | transmembrane transport | IEA |
Component
| ID | Name | Evidence |
| GO:0001518 | voltage-gated sodium channel complex | IEA |
| GO:0005886 | plasma membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
| GO:0044299 | C-fiber | IEA |
Function
| ID | Name | Evidence |
| GO:0005244 | voltage-gated ion channel activity | IEA |
| GO:0005248 | voltage-gated sodium channel activity | IEA |
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