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SCN10A sodium channel, voltage-gated, type X, alpha subunit [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001293306 Homo sapiens sodium channel, voltage-gated, type X, alpha subunit (SCN10A), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
NM_001293307 Homo sapiens sodium channel, voltage-gated, type X, alpha subunit (SCN10A), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
NM_006514 Homo sapiens sodium channel, voltage-gated, type X, alpha subunit (SCN10A), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005265371 PREDICTED: Homo sapiens sodium channel, voltage-gated, type X, alpha subunit (SCN10A), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $2699.00 30

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Gene Symbol SCN10A
Entrez Gene ID 6336
Full Name sodium channel, voltage-gated, type X, alpha subunit
Synonyms FEPS2, Nav1.8, PN3, SNS, hPN3
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p22.2

Summary The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Disorder

MIM: 604427

mRNA Protein Product Sequence Price Select
NM_001293306, 648216355 NP_001280235, 648216356 sodium channel protein type 10 subunit alpha isoform 2 ORF Sequence $2500.00
NM_001293307, 648216357 NP_001280236, 648216358 sodium channel protein type 10 subunit alpha isoform 3 ORF Sequence $2500.00
NM_006514, 110835709 NP_006505, 110835710 sodium channel protein type 10 subunit alpha isoform 1 ORF Sequence $2500.00
XM_005265371, 530372953 XP_005265428, 530372954 sodium channel protein type 10 subunit alpha isoform X1 ORF Sequence $2500.00
Homo sapiens (human)SCN10ANP_006505.2
Pan troglodytes (chimpanzee)SCN10AXP_516372.3
Macaca mulatta (Rhesus monkey)SCN10AXP_002808374.1
Canis lupus familiaris (dog)SCN10ANP_001003203.1
Bos taurus (cattle)SCN10AXP_002696962.1
Mus musculus (house mouse)Scn10aNP_001192250.1
Rattus norvegicus (Norway rat)Scn10aNP_058943.1
Process
IDNameEvidence
GO:0002027regulation of heart rateIMP
GO:0006814sodium ion transportTAS
GO:0007600sensory perceptionTAS
GO:0019228neuronal action potentialIBA
GO:0019233sensory perception of painIEA
GO:0034765regulation of ion transmembrane transportIDA
GO:0035725sodium ion transmembrane transportIDA
GO:0055117regulation of cardiac muscle contractionIMP
GO:0060371regulation of atrial cardiac muscle cell membrane depolarizationIMP
GO:0086010membrane depolarization during action potentialIBA
GO:0086067AV node cell to bundle of His cell communicationIMP
GO:0086069bundle of His cell to Purkinje myocyte communicationIMP
Component
IDNameEvidence
GO:0001518voltage-gated sodium channel complexIDA
GO:0044299C-fiberIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005248voltage-gated sodium channel activityIDA
GeneCards SCN10A
UniProt Q9Y5Y9
Vega OTTHUMG00000048245
MIM 604427
Ensembl ENSG00000185313
HGNC 10582
HPRD 09188

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SCN10A gene?

The SCN10A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged sodium atoms (sodium ions) into cells, play a key role in a cell's ability to generate and transmit electrical signals.

The SCN10A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.8. NaV1.8 sodium channels are found in nerve cells called nociceptors that transmit pain signals. Nociceptors are part of the peripheral nervous system, which connects the brain and spinal cord to cells that detect sensations such as touch, smell, and pain. Nociceptors are primarily involved in transmitting pain signals. The centers of nociceptors, known as the cell bodies, are located in a part of the spinal cord called the dorsal root ganglion. Fibers called axons extend from the cell bodies, reaching throughout the body to receive sensory information. In addition to nociceptors, NaV1.8 sodium channels have also been found in heart muscle cells where, by controlling the flow of sodium ions, they likely play a role in maintaining a normal heart rhythm.

Interactant

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