Sequence in raw or FASTA format:
SCN10A sodium channel, voltage-gated, type X, alpha subunit [Homo sapiens (human)]
|Entrez Gene ID||6336|
|Full Name||sodium channel, voltage-gated, type X, alpha subunit|
|Synonyms||FEPS2, Nav1.8, PN3, SNS, hPN3|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].|
|Homo sapiens (human)||SCN10A||NP_006505.2|
|Pan troglodytes (chimpanzee)||SCN10A||XP_516372.3|
|Macaca mulatta (Rhesus monkey)||SCN10A||XP_002808374.1|
|Canis lupus familiaris (dog)||SCN10A||NP_001003203.1|
|Bos taurus (cattle)||SCN10A||XP_002696962.1|
|Mus musculus (house mouse)||Scn10a||NP_001192250.1|
|Rattus norvegicus (Norway rat)||Scn10a||NP_058943.1|
|GO:0002027||regulation of heart rate||IMP|
|GO:0006814||sodium ion transport||TAS|
|GO:0019228||neuronal action potential||IBA|
|GO:0019233||sensory perception of pain||IEA|
|GO:0034765||regulation of ion transmembrane transport||IDA|
|GO:0035725||sodium ion transmembrane transport||IDA|
|GO:0055117||regulation of cardiac muscle contraction||IMP|
|GO:0060371||regulation of atrial cardiac muscle cell membrane depolarization||IMP|
|GO:0086010||membrane depolarization during action potential||IBA|
|GO:0086067||AV node cell to bundle of His cell communication||IMP|
|GO:0086069||bundle of His cell to Purkinje myocyte communication||IMP|
|GO:0001518||voltage-gated sodium channel complex||IDA|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0005248||voltage-gated sodium channel activity||IDA|
What is the normal function of the SCN10A gene?
The SCN10A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged sodium atoms (sodium ions) into cells, play a key role in a cell's ability to generate and transmit electrical signals.
The SCN10A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.8. NaV1.8 sodium channels are found in nerve cells called nociceptors that transmit pain signals. Nociceptors are part of the peripheral nervous system, which connects the brain and spinal cord to cells that detect sensations such as touch, smell, and pain. Nociceptors are primarily involved in transmitting pain signals. The centers of nociceptors, known as the cell bodies, are located in a part of the spinal cord called the dorsal root ganglion. Fibers called axons extend from the cell bodies, reaching throughout the body to receive sensory information. In addition to nociceptors, NaV1.8 sodium channels have also been found in heart muscle cells where, by controlling the flow of sodium ions, they likely play a role in maintaining a normal heart rhythm.
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