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SCNN1B sodium channel, non-voltage-gated 1, beta subunit [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000336 Homo sapiens sodium channel, non-voltage-gated 1, beta subunit (SCNN1B), mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005255467 PREDICTED: Homo sapiens sodium channel, non-voltage-gated 1, beta subunit (SCNN1B), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol SCNN1B
Entrez Gene ID 6338
Full Name sodium channel, non-voltage-gated 1, beta subunit
Synonyms BESC1, ENaCb, ENaCbeta, SCNEB
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009].

MIM: 600760

Liddle syndrome, 177200 (3); Pseudohypoaldosteronism, type I, 264350

mRNA Protein Product Sequence Price Select
NM_000336, 124301195 NP_000327, 124301196 amiloride-sensitive sodium channel subunit beta ORF Sequence $700.00
XM_005255467, 530408653 XP_005255524, 530408654 amiloride-sensitive sodium channel subunit beta isoform X1 ORF Sequence $700.00
hsa04742Taste transduction
hsa04960Aldosterone-regulated sodium reabsorption
REACT_15518Transmembrane transport of small molecules
REACT_25300Ion channel transport
REACT_160189Stimuli-sensing channels
Homo sapiens (human)SCNN1BNP_000327.2
Pan troglodytes (chimpanzee)SCNN1BXP_001161438.2
Macaca mulatta (Rhesus monkey)SCNN1BXP_001093933.1
Canis lupus familiaris (dog)SCNN1BXP_005621478.1
Bos taurus (cattle)SCNN1BNP_001091544.1
Mus musculus (house mouse)Scnn1bNP_035455.1
Rattus norvegicus (Norway rat)Scnn1bNP_036780.1
Gallus gallus (chicken)SCNN1BXP_425247.3
Xenopus (Silurana) tropicalis (western clawed frog)scnn1bNP_001072437.1
GO:0006814sodium ion transportTAS
GO:0034220ion transmembrane transportTAS
GO:0035725sodium ion transmembrane transportIDA
GO:0050891multicellular organismal water homeostasisIDA
GO:0050896response to stimulusIEA
GO:0050909sensory perception of tasteIEA
GO:0055078sodium ion homeostasisIDA
GO:0055085transmembrane transportTAS
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0009897external side of plasma membraneIEA
GO:0016324apical plasma membraneIEA
GO:0034706sodium channel complexIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0005515protein bindingIPI
GO:0015280ligand-gated sodium channel activityIDA
GO:0050699WW domain bindingIPI
GeneCards SCNN1B
UniProt P51168, B2R812
Vega OTTHUMG00000131608
MIM 600760
Ensembl ENSG00000168447
HGNC 10600
HPRD 02861

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SCNN1B gene?

The SCNN1B gene provides instructions for making one piece, the beta subunit, of a protein complex called the epithelial sodium channel (ENaC). The channel is composed of alpha, beta, and gamma subunits, each of which is produced from a different gene. These channels are found at the surface of certain cells called epithelial cells in many tissues of the body, including the kidneys, lungs, colon, and sweat glands. The ENaC channel transports sodium into cells.

In the kidney, ENaC channels open in response to signals that sodium levels in the blood are too low, which allows sodium to flow into cells. From the kidney cells, this sodium is returned to the bloodstream (a process called reabsorption) rather than being removed from the body in urine. In addition to regulating the amount of sodium in the body, the flow of sodium ions helps control the movement of water in tissues. For example, ENaC channels in lung cells help regulate the amount of fluid in the lungs.


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