SCP2 sterol carrier protein 2 [Homo sapiens (human)]

Gene Symbol	SCP2
Entrez Gene ID	6342
Full Name	sterol carrier protein 2
Synonyms	DKFZp686C12188, DKFZp686D11188, NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:1 Map Location:1p32
Summary	This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
Disorder	MIM: 184755 Leukoencephalopathy with dystonia and motor neuropathy, 613724 (3)

mRNA	NM_002979, 302344758
Protein	NP_002970, 19923233
Product	non-specific lipid-transfer protein isoform 1 proprotein
RefSeq Status	REVIEWED
mRNA	NM_001007098, 302318894
Protein	NP_001007099, 55956775
Product	non-specific lipid-transfer protein isoform 2
RefSeq Status	REVIEWED
mRNA	NM_001007250, 302344765
Protein	NP_001007251, 55956781
Product	non-specific lipid-transfer protein isoform 3 proprotein
RefSeq Status	REVIEWED
mRNA	NM_001007099, 302344763
Protein	NP_001007100, 55956777
Product	non-specific lipid-transfer protein isoform 5 proprotein
RefSeq Status	REVIEWED
mRNA	NM_001007100, 302344764
Protein	NP_001007101, 55956779
Product	non-specific lipid-transfer protein isoform 4 proprotein
RefSeq Status	REVIEWED
mRNA	NM_001193599, 302344759
Protein	NP_001180528, 302344760
Product	non-specific lipid-transfer protein isoform 7 proprotein
RefSeq Status	REVIEWED
mRNA	NM_001193600, 302344761
Protein	NP_001180529, 302344762
Product	non-specific lipid-transfer protein isoform 6 proprotein
RefSeq Status	REVIEWED
mRNA	NM_001193617, 302344766
Protein	NP_001180546, 302344767
Product	non-specific lipid-transfer protein isoform 8 proprotein
RefSeq Status	REVIEWED

KEGG

hsa00120	Primary bile acid biosynthesis
hsa03320	PPAR signaling pathway
hsa01100	Metabolic pathways
hsa04146	Peroxisome

WikiPathways

WP368

Mitochondrial LC-Fatty Acid Beta-Oxidation

Reactome

REACT_17017	Beta-oxidation of pristanoyl-CoA
REACT_11054	Synthesis of bile acids and bile salts
REACT_22258	Metabolism of lipids and lipoproteins
REACT_11040	Bile acid and bile salt metabolism
REACT_11041	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
REACT_16957	Peroxisomal lipid metabolism

Homo sapiens (human)	SCP2	NP_002970.2
Pan troglodytes (chimpanzee)	SCP2	XP_513413.2
Canis lupus familiaris (dog)	SCP2	XP_866097.1
Bos taurus (cattle)	SCP2	NP_001029162.2
Mus musculus (house mouse)	Scp2	NP_035457.1
Rattus norvegicus (Norway rat)	Scp2	NP_612517.2
Gallus gallus (chicken)	SCP2	XP_422482.2
Danio rerio (zebrafish)	scp2	NP_957159.1
Drosophila melanogaster (fruit fly)	ScpX	NP_524715.2
Caenorhabditis elegans	Y57A10C.6	NP_496639.1

Process

ID	Name	Evidence
GO:0006694	steroid biosynthetic process	TAS
GO:0006699	bile acid biosynthetic process	TAS
GO:0006810	transport	IEA
GO:0006869	lipid transport	IEA
GO:0007031	peroxisome organization	IEA
GO:0008206	bile acid metabolic process	TAS
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	TAS
GO:0044255	cellular lipid metabolic process	EXP

Component

ID	Name	Evidence
GO:0005634	nucleus	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IEA
GO:0005777	peroxisome	IEA
GO:0005782	peroxisomal matrix	TAS
GO:0043231	intracellular membrane-bounded organelle	IDA

Function

ID	Name	Evidence
GO:0005515	protein binding	IPI
GO:0008289	lipid binding	IEA
GO:0016740	transferase activity	IEA
GO:0032934	sterol binding	IEA
GO:0033814	propanoyl-CoA C-acyltransferase activity	IEA
GO:0050632	propionyl-CoA C2-trimethyltridecanoyltransferase activity	TAS

GeneCards	SCP2
PDB	1QND, 2C0L
UniProt	Q59HG9, B2R761, P22307, E1B6W5, Q6NXF4, B4DGJ9, B4DHP6, C9JC79, A6NM69
MIM	184755
Ensembl	ENSG00000116171
HGNC	10606
HPRD	01700

RefSeq Accession	Definition	Sequence	Price	Select
NM_002979	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 1, mRNA.	Full Length	$790.25
NM_002979		ORF Sequence	$476.76
NM_001007098	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 2, mRNA.	Full Length	$623.50
NM_001007098		ORF Sequence	$281.01
NM_001007250	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 5, mRNA.	Full Length	$376.42
NM_001007250		ORF Sequence	$159.00
NM_001007099	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 3, mRNA.	Full Length	$414.12
NM_001007099		ORF Sequence	$159.00
NM_001007100	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 4, mRNA.	Full Length	$411.51
NM_001007100		ORF Sequence	$159.00
NM_001193599	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 7, mRNA.	Full Length	$769.37
NM_001193599		ORF Sequence	$455.88
NM_001193600	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 6, mRNA.	Full Length	$751.97
NM_001193600		ORF Sequence	$438.48
NM_001193617	Homo sapiens sterol carrier protein 2 (SCP2), transcript variant 8, mRNA.	Full Length	$773.43
NM_001193617		ORF Sequence	$406.29