CCL2 chemokine (C-C motif) ligand 2 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	CCL2
Entrez Gene ID	6347
Full Name	chemokine (C-C motif) ligand 2
Synonyms	GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:17 Map Location:17q11.2-q12
Summary	This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq].
Disorder	MIM: 158105 {HIV-1, resistance to}, 609423 (3); {Spina bifida, susceptibility

mRNA	NM_002982, 56119169
Protein	NP_002973, 4506841
Product	C-C motif chemokine 2 precursor
RefSeq Status	REVIEWED

KEGG

hsa05144	Malaria
hsa05323	Rheumatoid arthritis
hsa05142	Chagas disease (American trypanosomiasis)
hsa04621	NOD-like receptor signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway

Pathway Interaction Database

il23pathway	IL23-mediated signaling events
fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2

WikiPathways

WP15	Selenium Pathway

Reactome

REACT_18277	PERK regulated gene expression
REACT_14819	Peptide ligand-binding receptors
REACT_15380	Diabetes pathways
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_14797	Signaling by GPCR
REACT_21340	GPCR ligand binding
REACT_18356	Unfolded Protein Response
REACT_15344	Chemokine receptors bind chemokines

Homo sapiens (human)	CCL2	NP_002973.1
Pan troglodytes (chimpanzee)	CCL2	XP_001174551.1
Canis lupus familiaris (dog)	CCL2	NP_001003297.1
Bos taurus (cattle)	CCL2	NP_776431.1
Mus musculus (house mouse)	Ccl12	NP_035461.2
Rattus norvegicus (Norway rat)	Ccl12	XP_213425.1

Process

ID	Name	Evidence
GO:0001525	angiogenesis	TAS
GO:0001666	response to hypoxia	IEA
GO:0001938	positive regulation of endothelial cell proliferation	IEA
GO:0002548	monocyte chemotaxis	IDA
GO:0006468	protein phosphorylation	TAS
GO:0006874	cellular calcium ion homeostasis	IEA
GO:0006916	anti-apoptosis	IDA
GO:0006935	chemotaxis	IEA
GO:0006954	inflammatory response	IEA
GO:0006959	humoral immune response	TAS
GO:0007155	cell adhesion	TAS
GO:0007165	signal transduction	NAS
GO:0007166	cell surface receptor linked signaling pathway	TAS
GO:0007179	transforming growth factor beta receptor signaling pathway	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	TAS
GO:0007259	JAK-STAT cascade	TAS
GO:0009408	response to heat	IEA
GO:0009612	response to mechanical stimulus	IEA
GO:0009617	response to bacterium	IEP
GO:0009887	organ morphogenesis	TAS
GO:0010332	response to gamma radiation	IEA
GO:0014823	response to activity	IEA
GO:0019079	viral genome replication	TAS
GO:0019221	cytokine-mediated signaling pathway	IDA
GO:0019725	cellular homeostasis	TAS
GO:0030593	neutrophil chemotaxis	IEA
GO:0031100	organ regeneration	IEA
GO:0032570	response to progesterone stimulus	IEA
GO:0033552	response to vitamin B3	IEA
GO:0035684	helper T cell extravasation	ISS
GO:0042493	response to drug	IEA
GO:0043200	response to amino acid stimulus	IEA
GO:0043277	apoptotic cell clearance	ISS
GO:0043615	astrocyte cell migration	IDA
GO:0045471	response to ethanol	IEA
GO:0046677	response to antibiotic	IEA
GO:0048010	vascular endothelial growth factor receptor signaling pathway	IEA
GO:0048246	macrophage chemotaxis	IDA
GO:0048247	lymphocyte chemotaxis	IEA
GO:0050806	positive regulation of synaptic transmission	IEA
GO:0050870	positive regulation of T cell activation	ISS
GO:0051384	response to glucocorticoid stimulus	IEA
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISS
GO:0060137	maternal process involved in parturition	IEA
GO:0070098	chemokine-mediated signaling pathway	IEA
GO:0071222	cellular response to lipopolysaccharide	ISS
GO:0071346	cellular response to interferon-gamma	ISS
GO:0071347	cellular response to interleukin-1	ISS
GO:0071356	cellular response to tumor necrosis factor	ISS

Component

ID	Name	Evidence
GO:0005576	extracellular region	EXP
GO:0005615	extracellular space	IEA
GO:0005737	cytoplasm	IEA
GO:0043025	neuronal cell body	IEA

Function

ID	Name	Evidence
GO:0004672	protein kinase activity	TAS
GO:0004871	signal transducer activity	TAS
GO:0005102	receptor binding	TAS
GO:0005515	protein binding	IPI
GO:0008009	chemokine activity	IEA
GO:0008201	heparin binding	IEA
GO:0031727	CCR2 chemokine receptor binding	ISS
GO:0031727	CCR2 chemokine receptor binding	TAS

GeneCards	CCL2
PDB	1DON, 2NZ1, 1ML0, 3IFD, 1DOK, 1DOL, 1MCA, 1DOM, 2BDN
UniProt	P13500
MIM	158105
Ensembl	ENSG00000108691
HGNC	10618
HPRD	01149

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RefSeq Accession	Definition	Sequence	Price	Select
NM_002982	Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA.	Full Length	$220.40
NM_002982	Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA.	ORF Sequence	$159.00