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CCL2 chemokine (C-C motif) ligand 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002982 Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

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Gene Symbol CCL2
Entrez Gene ID 6347
Full Name chemokine (C-C motif) ligand 2
Synonyms GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
General protein information
Preferred Names
C-C motif chemokine 2
Names
C-C motif chemokine 2
small-inducible cytokine A2
monocyte secretory protein JE
monocyte chemotactic protein 1
monocyte chemoattractant protein 1
monocyte chemoattractant protein-1
monocyte chemotactic and activating factor
small inducible cytokine subfamily A (Cys-Cys), member 2
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2-q12

Summary This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013].
Disorder

MIM: 158105

{HIV-1, resistance to}, 609423 (3); {Spina bifida, susceptibility

mRNA Protein Product Sequence Price Select
NM_002982, 56119169 NP_002973, 4506841 C-C motif chemokine 2 precursor ORF Sequence $99.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05144Malaria
hsa05323Rheumatoid arthritis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa04668TNF signaling pathway
WikiPathways
WP15Selenium Pathway
WP2374Oncostatin M Signaling Pathway
WP2036TWEAK Signaling Pathway
WP2431Spinal Cord Injury
Pathway Interaction Database
il23pathwayIL23-mediated signaling events
fra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
Reactome
REACT_18356Unfolded Protein Response (UPR)
REACT_18277PERK regulates gene expression
REACT_17015Metabolism of proteins
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_15344Chemokine receptors bind chemokines
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_18355ATF4 activates genes
Homo sapiens (human)CCL2NP_002973.1
Pan troglodytes (chimpanzee)CCL2XP_001174551.1
Macaca mulatta (Rhesus monkey)CCL2NP_001027993.1
Canis lupus familiaris (dog)CCL2NP_001003297.1
Bos taurus (cattle)CCL2NP_776431.1
Mus musculus (house mouse)Ccl12NP_035461.2
Rattus norvegicus (Norway rat)Ccl12NP_001099292.1
Process
IDNameEvidence
GO:0000165MAPK cascadeIMP
GO:0001525angiogenesisTAS
GO:0001666response to hypoxiaIEA
GO:0001938positive regulation of endothelial cell proliferationIEA
GO:0002548monocyte chemotaxisIDA
GO:0006468protein phosphorylationTAS
GO:0006874cellular calcium ion homeostasisIEA
GO:0006935chemotaxisTAS
GO:0006954inflammatory responseIDA
GO:0006959humoral immune responseTAS
GO:0006987activation of signaling protein activity involved in unfolded protein responseTAS
GO:0007010cytoskeleton organizationIDA
GO:0007155cell adhesionTAS
GO:0007165signal transductionNAS
GO:0007166cell surface receptor signaling pathwayTAS
GO:0007179transforming growth factor beta receptor signaling pathwayIEA
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTAS
GO:0007259JAK-STAT cascadeTAS
GO:0007568agingIEA
GO:0008360regulation of cell shapeIDA
GO:0009408response to heatIEA
GO:0009612response to mechanical stimulusIEA
GO:0009617response to bacteriumIEP
GO:0009887organ morphogenesisTAS
GO:0010332response to gamma radiationIEA
GO:0010574regulation of vascular endothelial growth factor productionIEA
GO:0010759positive regulation of macrophage chemotaxisIEA
GO:0014823response to activityIEA
GO:0016525negative regulation of angiogenesisIEA
GO:0019079viral genome replicationTAS
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0019725cellular homeostasisTAS
GO:0030593neutrophil chemotaxisIEA
GO:0030968endoplasmic reticulum unfolded protein responseTAS
GO:0031100organ regenerationIEA
GO:0031663lipopolysaccharide-mediated signaling pathwayIDA
GO:0032570response to progesteroneIEA
GO:0033552response to vitamin B3IEA
GO:0034351negative regulation of glial cell apoptotic processIDA
GO:0035684helper T cell extravasationISS
GO:0042493response to drugIEA
GO:0043200response to amino acidIEA
GO:0043491protein kinase B signalingIMP
GO:0043524negative regulation of neuron apoptotic processIDA
GO:0043615astrocyte cell migrationIDA
GO:0044267cellular protein metabolic processTAS
GO:0044344cellular response to fibroblast growth factor stimulusIEP
GO:0045471response to ethanolIEA
GO:0046677response to antibioticIEA
GO:0048010vascular endothelial growth factor receptor signaling pathwayIEA
GO:0048246macrophage chemotaxisIDA
GO:0048247lymphocyte chemotaxisIEA
GO:0050806positive regulation of synaptic transmissionIEA
GO:0050870positive regulation of T cell activationISS
GO:0051384response to glucocorticoidIEA
GO:0051770positive regulation of nitric-oxide synthase biosynthetic processISS
GO:0060137maternal process involved in parturitionIEA
GO:0070098chemokine-mediated signaling pathwayIEA
GO:0071222cellular response to lipopolysaccharideISS
GO:0071346cellular response to interferon-gammaIEP
GO:0071346cellular response to interferon-gammaISS
GO:0071347cellular response to interleukin-1IEP
GO:0071347cellular response to interleukin-1ISS
GO:0071356cellular response to tumor necrosis factorIEP
GO:0071356cellular response to tumor necrosis factorISS
GO:0071407cellular response to organic cyclic compoundIDA
GO:0090265positive regulation of immune complex clearance by monocytes and macrophagesIEA
GO:0090280positive regulation of calcium ion importIDA
GO:2000427positive regulation of apoptotic cell clearanceISS
GO:2000502negative regulation of natural killer cell chemotaxisIDA
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0005737cytoplasmIEA
GO:0043025neuronal cell bodyIEA
Function
IDNameEvidence
GO:0004672protein kinase activityTAS
GO:0005102receptor bindingTAS
GO:0008009chemokine activityIEA
GO:0008201heparin bindingIEA
GO:0031727CCR2 chemokine receptor bindingISS
GO:0031727CCR2 chemokine receptor bindingTAS
GeneCards CCL2
PDB 1DON, 2NZ1, 1ML0, 3IFD, 1DOK, 1DOL, 1MCA, 4DN4, 1DOM, 2BDN
UniProt P13500
Vega OTTHUMG00000132887
MIM 158105
Ensembl ENSG00000108691
HGNC 10618
HPRD 01149

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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