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CCL2 chemokine (C-C motif) ligand 2 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002982 Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
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Gene Symbol CCL2
Entrez Gene ID 6347
Full Name chemokine (C-C motif) ligand 2
Synonyms GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2-q12

Summary This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2008].
Disorder

MIM: 158105

{HIV-1, resistance to}, 609423 (3); {Spina bifida, susceptibility

mRNA Protein Product Sequence Price Select
NM_002982, 56119169 NP_002973, 4506841 C-C motif chemokine 2 Full Length $220.40
ORF Sequence $159.00
KEGG
hsa04062Chemokine signaling pathway
hsa05323Rheumatoid arthritis
hsa05164Influenza A
hsa05144Malaria
hsa05142Chagas disease (American trypanosomiasis)
hsa05168Herpes simplex infection
hsa04621NOD-like receptor signaling pathway
hsa04060Cytokine-cytokine receptor interaction
WikiPathways
WP2036TWEAK Signaling Pathway
WP2374Oncostatin M Signaling Pathway
WP15Selenium Pathway
Pathway Interaction Database
fra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
il23pathwayIL23-mediated signaling events
Reactome
REACT_116125Disease
REACT_15344Chemokine receptors bind chemokines
REACT_18355Activation of Genes by ATF4
REACT_14819Peptide ligand-binding receptors
REACT_18277PERK regulated gene expression
REACT_111102Signal Transduction
REACT_15380Diabetes pathways
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_21340GPCR ligand binding
REACT_18356Unfolded Protein Response
Homo sapiens (human)CCL2NP_002973.1
Pan troglodytes (chimpanzee)CCL2XP_001174551.1
Macaca mulatta (Rhesus monkey)CCL2NP_001027993.1
Canis lupus familiaris (dog)CCL2NP_001003297.1
Bos taurus (cattle)CCL2NP_776431.1
Mus musculus (house mouse)Ccl12NP_035461.2
Rattus norvegicus (Norway rat)Ccl12NP_001099292.1
GeneCards CCL2
PDB 1DON, 2NZ1, 1ML0, 3IFD, 1DOK, 1DOL, 1MCA, 4DN4, 1DOM, 2BDN
UniProt P13500
MIM 158105
Ensembl ENSG00000108691
HGNC 10618
HPRD 01149

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
C-C motif chemokine 2
Names
C-C motif chemokine 2
small-inducible cytokine A2
monocyte secretory protein JE
monocyte chemotactic protein 1
monocyte chemoattractant protein 1
monocyte chemoattractant protein-1
monocyte chemotactic and activating factor
small inducible cytokine subfamily A (Cys-Cys), member 2
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)

Interactant

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